المؤلفون: Michela Puxeddu, Jianchao Wu, Ruoli Bai, Michele D’Ambrosio, Marianna Nalli, Antonio Coluccia, Simone Manetto, Alessia Ciogli, Domiziana Masci, Andrea Urbani, Cinzia Fionda, Sonia Coni, Rosa Bordone, Gianluca Canettieri, Chiara Bigogno, Giulio Dondio, Ernest Hamel, Te Liu, Romano Silvestri, Giuseppe La Regina

المصدر: Journal of medicinal chemistry. 65(23)

مصطلحات موضوعية: Ovarian Neoplasms, Mice, Tubulin, Cell Line, Tumor, Drug Discovery, Molecular Medicine, Humans, Animals, Female, Pyrroles, Apoptosis, Tubulin Modulators

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e537297ba1d657b358721ec95924b69Test
https://pubmed.ncbi.nlm.nih.gov/36395526Test

المؤلفون: Puxeddu, Michela, Wu, Jianchao, Bai, Ruoli, D'Ambrosio, Michele, Nalli, Marianna, Coluccia, Antonio, Manetto, Simone, Ciogli, Alessia, Masci, Domiziana, Urbani, Andrea, Fionda, Cinzia, Coni, Sonia, Bordone, Rosa, Canettieri, Gianluca, Bigogno, Chiara, Dondio, Giulio, Hamel, Ernest, Liu, Te, Silvestri, Romano, La Regina, Giuseppe

المصدر: Journal of Medicinal Chemistry; 12/8/2022, Vol. 65 Issue 23, p15805-15818, 14p

المؤلفون: Seppo Auriola, Kasper B. Hansen, Mikko Gynther, Yevheniia Ishchenko, Darryl S. Pickering, Birgitte Nielsen, Aleksanteri Petsalo, Younes Larsen, Liwei Han, Jacob C. Hansen, Silke Kayser, Ilaria Proietti Silvestri, Tarja Malm, Lennart Bunch

المصدر: Journal of Medicinal Chemistry. 60:9885-9904

مصطلحات موضوعية: Niacinamide, 0301 basic medicine, Sorafenib, Carcinoma, Hepatocellular, Antineoplastic Agents, Receptors, N-Methyl-D-Aspartate, Article, Mice, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Cytotoxic T cell, Receptor, Chemistry, Phenylurea Compounds, Liver Neoplasms, Antagonist, Lipid signaling, Drug Resistance, Multiple, 030104 developmental biology, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, Molecular Medicine, NMDA receptor, Ionotropic glutamate receptor, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d18f06ffb40ecf3c324f127febf63d4Test
https://doi.org/10.1021/acs.jmedchem.7b01624Test

المؤلفون: Peiwen Pan, Giuseppe La Regina, Elisa Nuti, Ludovica Monti, Vincenzo Alterio, Antonio Coluccia, Sveva Pelliccia, Claudiu T. Supuran, Romano Silvestri, Seppo Parkkila, Simona Maria Monti, Valeria Famiglini, Giuseppina De Simone, Armando Rossello, Daniela Vullo

المساهمون: La Regina, G., Coluccia, A., Famiglini, V., Pelliccia, S., Monti, L., Vullo, D., Nuti, E., Alterio, V., De Simone, G., Monti, S. M., Pan, P., Parkkila, S., Supuran, C. T., Rossello, A., Silvestri, R.

المصدر: Journal of Medicinal Chemistry. 58:8564-8572

مصطلحات موضوعية: Models, Molecular, Carbonic Anhydrase Inhibitor, Molecular model, drug design, Stereochemistry, Crystallography, X-Ray, Adduct, Carbonic Anhydrase, Structure-Activity Relationship, Carbonic anhydrase, Drug Discovery, medicine, Humans, Structure–activity relationship, Carbonic Anhydrase Inhibitors, cristallography, Carbonic Anhydrases, chemistry.chemical_classification, activators, Sulfonamides, biology, IX, targets, Biphenyl Compounds, Lyase, Biphenyl compound, Enzyme, chemistry, Biochemistry, Biphenyl Compound, biology.protein, Molecular Medicine, Acetazolamide, Human, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f12cc46794e8674b63826b578a8e6186Test
https://doi.org/10.1021/acs.jmedchem.5b01144Test

المؤلفون: Romano Silvestri, Michelle Glass, Erin E. Cawston, Mark Connor, Vincenzo Di Marzo

المصدر: Journal of medicinal chemistry 58 (2015): 5979–5988. doi:10.1021/acs.jmedchem.5b00579
info:cnr-pdr/source/autori:Cawston, Erin E.; Connor, Mark; Di Marzo, Vincenzo; Silvestri, Romano; Glass, Michelle/titolo:Distinct Temporal Fingerprint for Cyclic Adenosine Monophosphate (cAMP) Signaling of Indole-2-carboxamides as Allosteric Modulators of the Cannabinoid Receptors/doi:10.1021%2Facs.jmedchem.5b00579/rivista:Journal of medicinal chemistry/anno:2015/pagina_da:5979/pagina_a:5988/intervallo_pagine:5979–5988/volume:58

مصطلحات موضوعية: Indoles, Allosteric modulator, Cannabinoid receptor, CB1 receptor, multiple-sclerosis, activation, internalization, mechanism, agonist, pathway, system, brain, model, Stereochemistry, medicine.medical_treatment, Allosteric regulation, chemistry.chemical_compound, Allosteric Regulation, Piperidines, Receptor, Cannabinoid, CB1, Drug Discovery, Cyclic AMP, medicine, Humans, Cyclic adenosine monophosphate, Potassium Channels, Inwardly Rectifying, Receptor, Chemistry, cannabinoid receptor, Hyperpolarization (biology), Cell biology, HEK293 Cells, Molecular Medicine, lipids (amino acids, peptides, and proteins), Cannabinoid, Signal transduction, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f17dc36c63d05653fb4aa58d217ce8e7Test
https://doi.org/10.1021/acs.jmedchem.5b00579Test

المؤلفون: Romano Silvestri, Simone Carradori

المصدر: Journal of Medicinal Chemistry. 58:6717-6732

مصطلحات موضوعية: Chemistry, Degenerative Disorder, Rational design, Pharmacology, medicine.disease, Anorexia nervosa, Personality disorders, Schizophrenia, Drug Discovery, medicine, Molecular Medicine, Dementia, Structure–activity relationship, Monoamine oxidase B

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::c55f38ddceda3a47f93448d62a2e38a8Test
https://doi.org/10.1021/jm501690rTest

المؤلفون: Romano Silvestri, Giuseppe La Regina, Antonio Coluccia, Marco Allarà, Ludovica Morera, Francesco Piscitelli, Ettore Novellino, Vincenzo Di Marzo, Alessia Ligresti

المساهمون: Piscitelli, F., Ligresti, A., La Regina, G., Coluccia, A., Morera, L., Allara, M., Novellino, Ettore, Di Marzo, V., Silvestri, R.

المصدر: Journal of medicinal chemistry (Online) 55 (2012): 5627–5631. doi:10.1021/jm201485c
info:cnr-pdr/source/autori:Piscitelli F, Ligresti A, La Regina G, Coluccia A, Morera L, Allarà M, Novellino E, Di Marzo V, Silvestri R./titolo:Indole-2-carboxamides as allosteric modulators of the cannabinoid CB1 receptor./doi:10.1021%2Fjm201485c/rivista:Journal of medicinal chemistry (Online)/anno:2012/pagina_da:5627/pagina_a:5631/intervallo_pagine:5627–5631/volume:55

مصطلحات موضوعية: Indole test, Cannabinoid receptor, Chemistry, medicine.drug_class, Stereochemistry, medicine.medical_treatment, Allosteric Regulation, Indoles, CB1 receptors, Chlorine atom, Allosteric regulation, Carboxamide, mental disorders, Drug Discovery, medicine, Molecular Medicine, Moiety, Cannabinoid, Receptor, psychological phenomena and processes

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28226f2689bcf876334e20c6b7bfb30Test
https://doi.org/10.1021/jm201485cTest

المؤلفون: Sahar Kandil, Antonio Coluccia, Ettore Novellino, Giuseppe La Regina, Anna Ivana Scovassi, Ennio Prosperi, José Fernando Díaz, Ruth Matesanz, Gabriella De Martino, Michael C. Edler, Romano Silvestri, Francesco Piscitelli, Antonio Lavecchia, Marino Artico, Andrea Brancale, Ernest Hamel

المساهمون: G., LA REGINA, M. C., Edler, A., Brancale, S., Kandil, A., Coluccia, F., Piscitelli, E., Hamel, G., DE MARTINO, R., Matesanz, J. F., Diaz, A. I., Scovassi, E., Prosperi, Lavecchia, Antonio, Novellino, Ettore, M., Artico, R., Silvestri

المصدر: Digital.CSIC. Repositorio Institucional del CSIC
instname

مصطلحات موضوعية: Models, Molecular, Indoles, antitubulin agent, Molecular model, Stereochemistry, Apoptosis, Ether, Radioligand Assay, Structure-Activity Relationship, chemistry.chemical_compound, Biopolymers, Tubulin, Cell Line, Tumor, Drug Discovery, Humans, Moiety, Cytotoxicity, Indole test, Combretastatin, biology, molecular modeling, Chemistry, Cell Cycle, Hydrogen Bonding, Biological activity, Tubulin Modulators, anticancer agent, biology.protein, Molecular Medicine, Drug Screening Assays, Antitumor, Protein Binding

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8245bebb8c2485bab5dc99858d94798eTest
https://doi.org/10.1021/jm061479uTest

المؤلفون: Gynther, Mikko, Proietti Silvestri, Ilaria, Hansen, Jacob C., Hansen, Kasper B., Malm, Tarja, Ishchenko, Yevheniia, Larsen, Younes, Han, Liwei, Kayser, Silke, Auriola, Seppo, Petsalo, Aleksanteri, Nielsen, Birgitte, Pickering, Darryl S., Bunch, Lennart

المصدر: Journal of Medicinal Chemistry; 20240101, Issue: Preprints

المؤلفون: Giuseppe La Regina, Lorenza Sisinni, Valeria Famiglini, Marianna Nalli, Stefania Vultaggio, Alberto Gulino, Giulio Dondio, Mario Varasi, Patrizia Lavia, Ernest Hamel, Vitalba Ruggieri, Ettore Novellino, Ciro Mercurio, Andrea Miele, Romano Silvestri, Sara Passacantilli, Whilelmina Maria Rensen, Alessio Bolognesi, Lucia Di Marcotullio, Andrea Brancale, Carmela Mazzoccoli, Sveva Pelliccia, Antonio Coluccia, Romina Alfonsi, Ruoli Bai

المساهمون: Giuseppe La Regina, Ruoli, Bai, Antonio, Coluccia, Valeria, Famiglini, Pelliccia, Sveva, Sara, Passacantilli, Carmela, Mazzoccoli, Vitalba, Ruggieri, Lorenza, Sisinni, Alessio, Bolognesi, Whilelmina Maria Rensen, Andrea, Miele, Marianna, Nalli, Romina, Alfonsi, Lucia Di Marcotullio, Alberto, Gulino, Andrea, Brancale, Novellino, Ettore, Giulio, Dondio, Stefania, Vultaggio, Mario, Varasi, Ciro, Mercurio, Ernest, Hamel, Patrizia, Lavia, Romano, Silvestri

المصدر: Journal of medicinal chemistry 57 (2014): 6531–6552. doi:10.1021/jm500561a
info:cnr-pdr/source/autori:La Regina, Giuseppe; Bai, Ruoli; Coluccia, Antonio; Famiglini, Valeria; Pelliccia, Sveva; Passacantilli, Sara; Mazzoccoli, Carmela; Ruggieri, Vitalba; Sisinni, Lorenza; Bolognesi, Alessio; Rensen, Whilelmina Maria; Miele, Andrea; Nalli, Marianna; Alfonsi, Romina; Di Marcotullio, Lucia; Gulino, Alberto; Brancale, Andrea; Novellino, Ettore; Dondio, Giulio; Vultaggio, Stefania; Varasi, Mario; Mercurio, Ciro; Hamel, Ernest; Lavia, Patrizia; Silvestri, Romano/titolo:New Pyrrole Derivatives with Potent Tubulin Polymerization Inhibiting Activity As Anticancer Agents Including Hedgehog-Dependent Cancer/doi:10.1021%2Fjm500561a/rivista:Journal of medicinal chemistry/anno:2014/pagina_da:6531/pagina_a:6552/intervallo_pagine:6531–6552/volume:57

مصطلحات موضوعية: Cell Membrane Permeability, drug design, Cell Survival, Antineoplastic Agents, Guanidines, Article, RS, Polymerization, Mice, Structure-Activity Relationship, hedgehog pathway, Tubulin, Cell Line, Tumor, Neoplasms, Drug Discovery, Animals, Humans, Hedgehog Proteins, Pyrroles, Hedgehog, Cell Proliferation, Aniline Compounds, biology, Cell Death, Chemistry, Cell growth, Tubulin Modulators, tubulin-binding drugs, cancer growth inhibition, Hedgehog signaling pathway, Molecular Docking Simulation, Biochemistry, Cell culture, Cancer cell, biology.protein, Molecular Medicine, M Phase Cell Cycle Checkpoints, Signal transduction, Drug Screening Assays, Antitumor, Colchicine, Protein Binding, Signal Transduction

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0415ed9efa3f7456b5dcb3a529131644Test
https://pubmed.ncbi.nlm.nih.gov/25025991Test