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1
المؤلفون: Ning Cao, Zhili Xin, Jennifer L. Freeman, Bo Liu, Teresa K. Surowy, Rich S. Janis, Hongyu Zhao, Christine A. Collins, Ruojing Yang, Michael D. Serby, Heidi S. Camp, Tom S. Suhar, Philip R. Kym, David W A Beno, Lynch John K, Gang Liu, Steven P Cepa, Harriet T. Smith, Hing L. Sham, Joel A. Krauser
المصدر: Journal of Medicinal Chemistry. 50:3086-3100
مصطلحات موضوعية: medicine.drug_class, Biological Availability, Carboxamide, In Vitro Techniques, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Biosynthesis, Oral administration, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, chemistry.chemical_classification, Oxadiazoles, Chemistry, In vitro, Rats, Pyridazines, Stearoyl-CoA Desaturase, Enzyme, Biochemistry, Microsomes, Liver, Microsome, Molecular Medicine, lipids (amino acids, peptides, and proteins), Acyl Coenzyme A, Stearoyl-CoA desaturase-1
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42af278811a494ed64ae2d19357a5e53Test
https://doi.org/10.1021/jm070219pTest -
2
المؤلفون: Gilbert Diaz, Lee C. Preusser, Ann Mikhail, Christopher A. Ogiela, Lynch John K, Philip R. Kym, Lisa M. Hernández, Dariusz Wodka, Gang Zhao, Doug H. Falls, Eugene N. Bush, James S. Polakowski, Andrew S. Judd, Robin Shapiro, Hing L. Sham, James J. Napier, Christine A. Collins, Kennan C. Marsh, Victoria Knourek-Segel, Glenn A. Reinhart, Thomas J Campbell, Sevan Brodjian, Michael E. Brune, Brian A. Droz, Mathew M. Mulhern, Kathryn Houseman, Regina M. Reilly, Brian D. Dayton, Ryan M. Fryer, James T. Limberis, Rajesh R. Iyengar, Freeman Jennifer C
المصدر: Journal of Medicinal Chemistry. 49:6569-6584
مصطلحات موضوعية: medicine.medical_specialty, Potassium Channels, medicine.drug_class, Acylation, hERG, Blood Pressure, Carboxamide, Cell Line, Rats, Sprague-Dawley, Electrocardiography, Mice, Structure-Activity Relationship, Dogs, Pharmacokinetics, Heart Rate, In vivo, Internal medicine, Drug Discovery, medicine, Animals, Potency, Benzodioxoles, Receptors, Somatostatin, biology, Chemistry, Body Weight, Antagonist, Potassium channel, Rats, Melanin-concentrating hormone receptor, Mice, Inbred C57BL, Endocrinology, Cardiovascular Diseases, Chromones, Area Under Curve, biology.protein, Molecular Medicine, Calcium, Female, Indicators and Reagents, Half-Life
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b667ab564d57ac2f27112dd9382a72abTest
https://doi.org/10.1021/jm060683eTest -
3
المؤلفون: Hing L. Sham, Regina M. Reilly, Freeman Jennifer C, Lee C. Preusser, Mathew M. Mulhern, Dariusz Wodka, Kennan C. Marsh, Andrew S. Judd, Jason A. Segreti, Ryan M. Fryer, Rajesh R. Iyengar, Gang Zhao, Lynch John K, Brian D. Dayton, Sevan Brodjian, Anil Vasudevan, Lisa M. Hernández, James J. Napier, Christine A. Collins, Seble Wagaw, Glenn A. Reinhart, Thomas J Campbell, Andrew J. Souers, Ju Gao, James S. Polakowski, Philip R. Kym
المصدر: Journal of Medicinal Chemistry. 49:2339-2352
مصطلحات موضوعية: Male, Drug, Indazoles, Melanin-concentrating hormone, media_common.quotation_subject, Blood Pressure, Pharmacology, Cardiovascular System, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Piperidines, In vivo, Cell Line, Tumor, Drug Discovery, Animals, Tissue Distribution, Receptors, Somatostatin, Receptor, media_common, Antagonist, Brain, Myocardial Contraction, Rats, Melanin-concentrating hormone receptor, Mice, Inbred C57BL, chemistry, Chromones, Hormone receptor, Toxicity, Molecular Medicine, Anti-Obesity Agents
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619be8483639af871b30640981ceee6dTest
https://doi.org/10.1021/jm0512286Test -
4
المؤلفون: Christine A. Collins, Victoria Knourek-Segel, Philip R. Kym, Dariusz Wodka, Hing L. Sham, Brad J. Geddes, Rajesh R. Iyengar, Anil Vasudevan, Ju Gao, Su Jen Lai, Elizabeth K. Govek, Thomas A. Fey, Freeman Jennifer C, Gang Zhao, Dennis G Fry, Michael E. Brune, Jennifer Lee Che, Brian D. Dayton, Doug H. Falls, Kennan C. Marsh, Andrew J. Souers, James Brown, Jon Roses, Michael A. Patane, Matthew J. LaMarche, Cathleen Mcdowell, Lee C. Preusser, Lisa E. Hernandez, Mathew M. Mulhern, Courtney Cullis, Tom Marsilje, Sevan Brodjian, Lynch John K, Eugene N. Bush, Sells Todd B, Robin Shapiro, Christopher Blackburn, Andrew S. Judd, Glenn A. Reinhart
المصدر: Journal of Medicinal Chemistry. 48:5888-5891
مصطلحات موضوعية: Male, medicine.medical_specialty, Melanin-concentrating hormone, Ratón, Administration, Oral, Biological Availability, Mice, Obese, Blood Pressure, Pharmacology, Eating, Mice, Radioligand Assay, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Piperidines, Pharmacokinetics, Coumarins, Oral administration, In vivo, Cell Line, Tumor, Internal medicine, Drug Discovery, medicine, Animals, Humans, Receptors, Pituitary Hormone, Receptors, Somatostatin, Antagonist, Brain, Myocardial Contraction, Melanin-concentrating hormone receptor, Endocrinology, chemistry, Anorectic, Molecular Medicine, Anti-Obesity Agents, Energy Metabolism
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b385adec4f57fc115bc33dad4a4acdf7Test
https://doi.org/10.1021/jm050598rTest -
5
المؤلفون: Mathew M. Mulhern, Yau Yi Lau, Hing L. Sham, Zhi Su, Gang Zhao, Brian A. Droz, Xiaojun Wang, Kennan C. Marsh, Seble Wagaw, Christine A. Collins, Jennifer L. Freeman, Michael E. Brune, Nelson Grihalde, Rajesh R. Iyengar, Kenneth M. Engstrom, Gilbert Diaz, Regina M. Reilly, Lynch John K, Matthew M. Ravn, David W A Beno, Philip R. Kym, Ju Gao, Sevan Brodjian, H. Doug Falls, Brian D. Dayton, Martin J. Voorbach, Dennis G Fry, Andrew J. Souers, Andrew S. Judd
المصدر: Journal of medicinal chemistry. 51(3)
مصطلحات موضوعية: medicine.medical_specialty, Eating, Mice, Structure-Activity Relationship, Anti-Obesity Agents, Pharmacokinetics, In vivo, Internal medicine, Drug Discovery, Weight Loss, medicine, Structure–activity relationship, Animals, Humans, Urea, Diacylglycerol O-Acyltransferase, Cycloheptanes, Triglycerides, Hypolipidemic Agents, Chemistry, Biphenyl Compounds, Stereoisomerism, medicine.disease, Keto Acids, Mice, Mutant Strains, Biphenyl compound, Isoenzymes, Endocrinology, Postprandial, Liver, Molecular Medicine, Dyslipidemia, Chylomicron
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c61d8d74e1723130c95fb0f63edbf2dfTest
https://pubmed.ncbi.nlm.nih.gov/18183944Test -
6
المؤلفون: Martin Winn, Jeffrey R. Huth, Zhonghua Pei, Jeff Kester, Thomas W. von Geldern, Lynch John K, Sandra Leitza, Devries Peter J, Gang Liu, Gregory F. Okasinski, Jennifer L. Freeman, Jae Hwan-Soo, R. Dickinson, Edward B. Reilly, and Donna Mussatto, Zhili Xin
المصدر: Journal of medicinal chemistry. 44(25)
مصطلحات موضوعية: Models, Molecular, Staphylococcus aureus, Indoles, Magnetic Resonance Spectroscopy, Stereochemistry, medicine.drug_class, Neutrophils, Ovalbumin, Intercellular Adhesion Molecule-1, Carboxamide, Sulfides, Chemical synthesis, Cell Line, chemistry.chemical_compound, Enterotoxins, Mice, Structure-Activity Relationship, Drug Discovery, medicine, Structure–activity relationship, Animals, Trifluoromethyl, Bicyclic molecule, Aryl, Adhesion, Pneumonia, Amides, Lymphocyte Function-Associated Antigen-1, Rats, Eosinophils, Chemotaxis, Leukocyte, chemistry, Cinnamates, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7563c8b6085d0eade93bc3625b45fd01Test
https://pubmed.ncbi.nlm.nih.gov/11728185Test -
7دورية
المؤلفون: K. Lynch, John, C. Freeman, Jennifer, S. Judd, Andrew, Iyengar, Rajesh, Mulhern, Mathew, Zhao, Gang, J. Napier, James, Wodka, Dariusz, Brodjian, Sevan, D. Dayton, Brian, Falls, Doug, Ogiela, Christopher, M. Reilly, Regina, J. Campbell, Thomas, S. Polakowski, James, Hernandez, Lisa, C. Marsh, Kennan, Shapiro, Robin, Knourek-Segel, Victoria, Droz, Brian, Bush, Eugene, Brune, Michael, C. Preusser, Lee, M. Fryer, Ryan, A. Reinhart, Glenn, Houseman, Kathryn, Diaz, Gilbert, Mikhail, Ann, T. Limberis, James, L. Sham, Hing, A. Collins, Christine, R. Kym, Philip
المصدر: Journal of Medicinal Chemistry; November 2006, Vol. 49 Issue: 22 p6569-6584, 16p
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8دورية
المؤلفون: R. Kym, Philip, J. Souers, Andrew, J. Campbell, Thomas, K. Lynch, John, S. Judd, Andrew, Iyengar, Rajesh, Vasudevan, Anil, Gao, Ju, C. Freeman, Jennifer, Wodka, Dariusz, Mulhern, Mathew, Zhao, Gang, H. Wagaw, Seble, J. Napier, James, Brodjian, Sevan, D. Dayton, Brian, M. Reilly, Regina, A. Segreti, Jason, M. Fryer, Ryan, C. Preusser, Lee, A. Reinhart, Glenn, Hernandez, Lisa, C. Marsh, Kennan, L. Sham, Hing, A. Collins, Christine, S. Polakowski, James
المصدر: Journal of Medicinal Chemistry; April 2006, Vol. 49 Issue: 7 p2339-2352, 14p