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1
المؤلفون: Helge Prinz, Ann-Kathrin Ridder, Igor Ivanov, Elham Aghaee, Kirsten Vogel, Jahan B. Ghasemi, Klaus Müller, Konrad J. Böhm
المصدر: Journal of Medicinal Chemistry. 60:749-766
مصطلحات موضوعية: 0301 basic medicine, Alkylating Agents, Cell cycle checkpoint, Stereochemistry, Quantitative Structure-Activity Relationship, Antineoplastic Agents, Phenylpiperazine, Piperazines, Polymerization, Flow cytometry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Phenothiazines, Tubulin, Phenothiazine, Oxazines, Drug Discovery, medicine, Humans, Moiety, chemistry.chemical_classification, medicine.diagnostic_test, Cell cycle, Ethylenediamines, Tubulin Modulators, G2 Phase Cell Cycle Checkpoints, Molecular Docking Simulation, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Molecular Medicine, K562 Cells, Phenoxazine, Tricyclic
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d9f3eff9fa6c396c780261d3c99165Test
https://doi.org/10.1021/acs.jmedchem.6b01591Test -
2
المؤلفون: Cathrin Lindenschmidt, Helge Prinz, Sven Bannwitz, Tobias Kalin, Klaus Müller, Jan Tentrop, Silke Vortherms, Nader Zahedi Golpayegani, Dirk Krane
المصدر: Journal of Medicinal Chemistry. 57:6226-6239
مصطلحات موضوعية: Stereochemistry, Redox, chemistry.chemical_compound, HaCaT, medicine.anatomical_structure, Mechanism of action, chemistry, Cytoplasm, Furan, Lactate dehydrogenase, Drug Discovery, medicine, Thiophene, Molecular Medicine, medicine.symptom, Keratinocyte
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::14765c3265ad33042f9bd01e462d2179Test
https://doi.org/10.1021/jm500754dTest -
3
المؤلفون: Manfred Kansy, Nicole A. Kratochwil, Daniel Zimmerli, Klaus Müller, Holger Fischer, Quentin A. Huchet, Björn Wagner, Bernd Kuhn, Erick M. Carreira
المصدر: Journal of medicinal chemistry. 58(22)
مصطلحات موضوعية: Halogenation, Fluorine Compounds, In Vitro Techniques, Structure-Activity Relationship, Computational chemistry, Aqueous solubility, Drug Discovery, Organic chemistry, Structure–activity relationship, Animals, Humans, Solubility, Structural motif, Biotransformation, Indole test, Drug discovery, Chemistry, Chemistry, Physical, Metabolic stability, Lipids, Protein Structure, Tertiary, Rats, Drug Design, Lipophilicity, Microsomes, Liver, Molecular Medicine, Thermodynamics
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::212aabc7028db46167dbc368fbaa3c65Test
https://pubmed.ncbi.nlm.nih.gov/26523333Test -
4
المؤلفون: Anne Zuse, Konrad J. Böhm, Eberhard Unger, Klaus Müller, Matthias Gerlach, Peter Schmidt, Helge Prinz, Silke Baasner, Eckhard Günther
المصدر: Journal of Medicinal Chemistry. 50:6059-6066
مصطلحات موضوعية: Stereochemistry, Thiophenes, Naphthalenes, HeLa, Structure-Activity Relationship, chemistry.chemical_compound, Tubulin, Cell Line, Tumor, Drug Discovery, medicine, Humans, Structure–activity relationship, Colchicine, Cytotoxicity, Podophyllotoxin, Anthracenes, biology, Tubulin Modulators, Nocodazole, Cell Cycle, biology.organism_classification, Biochemistry, chemistry, Drug Resistance, Neoplasm, biology.protein, Molecular Medicine, Drug Screening Assays, Antitumor, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8db5ecab3c11610b56e6707e7ebb4161Test
https://doi.org/10.1021/jm0708984Test -
5
المؤلفون: Peter Schmidt, Eberhard Unger, Konrad J. Böhm, Matthias Gerlach, Eckhard Günther, Helge Prinz, Silke Baasner, Anne Zuse, Klaus Müller
المصدر: Journal of Medicinal Chemistry. 49:7816-7825
مصطلحات موضوعية: Cell Survival, Antineoplastic Agents, Thiophenes, HeLa, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Tubulin, Drug Discovery, Tumor Cells, Cultured, Animals, Humans, Colchicine, Cytotoxicity, Cell Proliferation, Molecular Structure, biology, Leukemia P388, Cell Cycle, Biological activity, Cell cycle, Flow Cytometry, biology.organism_classification, Tubulin Modulators, In vitro, Biochemistry, chemistry, Drug Resistance, Neoplasm, Cell culture, biology.protein, Molecular Medicine, Female, Drug Screening Assays, Antitumor, K562 Cells
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e71153d17982a2828e78ddc96649df99Test
https://doi.org/10.1021/jm0605031Test -
6
المؤلفون: Sven, Bannwitz, Dirk, Krane, Silke, Vortherms, Tobias, Kalin, Cathrin, Lindenschmidt, Nader, Zahedi Golpayegani, Jan, Tentrop, Helge, Prinz, Klaus, Müller
المصدر: Journal of medicinal chemistry. 57(14)
مصطلحات موضوعية: Keratinocytes, Structure-Activity Relationship, Dose-Response Relationship, Drug, Molecular Structure, Humans, Tabebuia, Oxidation-Reduction, Cells, Cultured, Cell Proliferation, Naphthoquinones
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::39e7a404a202433fd088612cc14b0034Test
https://pubmed.ncbi.nlm.nih.gov/24964246Test -
7
المؤلفون: Klaus Müller, Helge Prinz
المصدر: Journal of Medicinal Chemistry. 40:2780-2787
مصطلحات موضوعية: Stereochemistry, Carboxylic Acids, Hydroxamic Acids, Chemical synthesis, Antioxidants, Cell Line, Lipid peroxidation, chemistry.chemical_compound, Drug Discovery, Animals, Humans, Psoriasis, Lipoxygenase Inhibitors, Cytotoxicity, Hydroxamic acid, biology, Hydroxyl Radical, Chemistry, Biological activity, HaCaT, Models, Chemical, Deoxyribose, Enzyme inhibitor, biology.protein, Molecular Medicine, Cattle, Oxidation-Reduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56a6eeddec8495fe386df8e84bc82130Test
https://doi.org/10.1021/jm9701785Test -
8
المؤلفون: Klaus Müller, Wolfgang Wiegrebe, Hsu Shan Huang
المصدر: Journal of Medicinal Chemistry. 39:3132-3138
مصطلحات موضوعية: Keratinocytes, Neutrophils, Leukotriene B4, Stereochemistry, Thio, Antioxidants, Lipid peroxidation, Mice, chemistry.chemical_compound, Hydroxyeicosatetraenoic Acids, Drug Discovery, medicine, Animals, Humans, Psoriasis, 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid, Lipoxygenase Inhibitors, Cells, Cultured, chemistry.chemical_classification, Molecular Structure, biology, Anthralin, HaCaT, Enzyme, medicine.anatomical_structure, chemistry, Deoxyribose, Biochemistry, Arachidonate 5-lipoxygenase, biology.protein, Molecular Medicine, Cattle, Epidermis, Keratinocyte, Cell Division
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1367996aa130881c1763c00dc98432deTest
https://doi.org/10.1021/jm960259lTest -
9
المؤلفون: Alexandra Reichstein, Jan Tentrop, Klaus Müller, Sven Bannwitz, Helge Prinz, Silke Vortherms
المصدر: Journal of medicinal chemistry. 55(16)
مصطلحات موضوعية: Keratinocytes, Dicumarol, Stereochemistry, Cell Line, chemistry.chemical_compound, Structure-Activity Relationship, Superoxides, Drug Discovery, medicine, NAD(P)H Dehydrogenase (Quinone), Structure–activity relationship, Humans, Psoriasis, Furans, Cell Proliferation, NADPH-Ferrihemoprotein Reductase, Oxadiazoles, L-Lactate Dehydrogenase, Chemistry, Superoxide, Cell Membrane, In vitro, Quinone, HaCaT, medicine.anatomical_structure, Biochemistry, Molecular Medicine, Dermatologic Agents, Keratinocyte, Intracellular, Naphthoquinones
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f44bfa5a0bf12c482de7242c92dc5e04Test
https://pubmed.ncbi.nlm.nih.gov/22845014Test -
10
المؤلفون: Ingo Gawlik, Klaus Müller, Klaus Ziereis, P. Leukel
المصدر: Journal of Medicinal Chemistry. 37:1660-1669
مصطلحات موضوعية: Keratinocytes, Antioxidant, Neutrophils, Administration, Topical, Membrane lipids, medicine.medical_treatment, Anti-Inflammatory Agents, Leukotriene B4, Antioxidants, Lipid peroxidation, Structure-Activity Relationship, chemistry.chemical_compound, Lipoxygenase, Malondialdehyde, Hydroxyeicosatetraenoic Acids, Drug Discovery, medicine, Animals, Humans, Psoriasis, Lipoxygenase Inhibitors, Cells, Cultured, Anthracenes, Molecular Structure, biology, Chemistry, Deoxyribose, Biochemistry, Enzyme inhibitor, Liposomes, Arachidonate 5-lipoxygenase, Lipophilicity, biology.protein, Molecular Medicine, Cattle, Lipid Peroxidation, Oxidation-Reduction, Cell Division
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ce551716a9a52c3dfc347dd39662c71Test
https://doi.org/10.1021/jm00037a017Test