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1
المؤلفون: Kenneth E. Rittle, Dorothy Levorse, James C. Barrow, Eric A. Price, Katherine Tugusheva, Ming Tain Lai, Abigail Wolfe, Dennis Colussi, Paul Zuck, Shaun R. Stauffer, Adam J. Simon, Samuel L. Graham, M. Katharine Holloway, Zhi Qiang Yang, Georgia B. McGaughey, Amy S. Espeseth, Phung L. Ngo, Beth Pietrak, Min Xu, Qian Huang, Joseph P. Vacca, Sethu Sankaranarayanan, Daria J. Hazuda, Sanjeev Munshi, Harold G. Selnick
المصدر: Journal of Medicinal Chemistry. 51:6259-6262
مصطلحات موضوعية: Models, Molecular, chemistry.chemical_classification, Molecular Structure, biology, Molecular model, Bicyclic molecule, Chemistry, Stereochemistry, Drug Evaluation, Preclinical, Hydrogen Bonding, Crystal structure, Crystallography, X-Ray, Imidazolidines, Chemical synthesis, Cocrystal, Structure-Activity Relationship, Enzyme, Piperidines, Enzyme inhibitor, Drug Discovery, biology.protein, Amyloid precursor protein, Molecular Medicine, Amyloid Precursor Protein Secretases, Enzyme Inhibitors
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b39bb3a2bd901885cd23cf513dd12eTest
https://doi.org/10.1021/jm800914nTest -
2
المؤلفون: Melissa S. Egbertson, Marc V. Witmer, Linghang Zhuang, James P. Guare, William A. Schleif, Abigail Wolfe, Payne Linda S, Peter J. Felock, Stuart R. Michelson, Daria J. Hazuda, Steven D. Young, John S. Wai, Joseph J. Lynch, Kara A. Stillmock, Joseph P. Vacca, Lori J. Gabryelski, Yvonne M. Leonard, Mark Embrey, Thorsten E. Fisher, Gregory Moyer
المصدر: Journal of Medicinal Chemistry. 46:453-456
مصطلحات موضوعية: Anti-HIV Agents, Administration, Oral, Cell Line, Structure-Activity Relationship, Drug Discovery, Animals, Humans, Structure–activity relationship, HIV Integrase Inhibitors, Naphthyridines, Cytotoxicity, chemistry.chemical_classification, biology, Chemistry, biology.organism_classification, Molecular biology, In vitro, Rats, Integrase, Enzyme, Biochemistry, Cell culture, Enzyme inhibitor, Injections, Intravenous, Lentivirus, HIV-1, biology.protein, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57954f828de9dea836bb7bbeec94991bTest
https://doi.org/10.1021/jm025553uTest -
3
المؤلفون: Izzat T. Raheem, Abbas M. Walji, Daniel Klein, John M. Sanders, David A. Powell, Pravien Abeywickrema, Guillaume Barbe, Amrith Bennet, Karla Childers, Melodie Christensen, Sophie−Dorothee Clas, David Dubost, Mark Embrey, Jay Grobler, Michael J. Hafey, Timothy J. Hartingh, Daria J. Hazuda, Jeffrey T. Kuethe, Jamie McCabe Dunn, Michael D. Miller, Keith P. Moore, Andrew Nolting, Natasa Pajkovic, Sangita Patel, Zuihui Peng, Vanessa Rada, Paul Rearden, John D. Schreier, John Sisko, Thomas G. Steele, Jean-François Truchon, John Wai, Min Xu, Paul J. Coleman
المصدر: Journal of Medicinal Chemistry. 59:486-486
مصطلحات موضوعية: Drug Discovery, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::d53c21b2e9fa9a0d92172bf87ab40930Test
https://doi.org/10.1021/acs.jmedchem.5b01957Test -
4
المؤلفون: Stacey R. Lindsley, Georgia B. McGaughey, Xiao-Ping Shi, Lawrence Kuo, Katherine Tugusheva, Hemaka A. Rajapakse, Min Xu, Adam J. Simon, Sanjeev Munshi, Ming-Tain Lai, Samuel L. Graham, Mary Beth Young, Dennis Colussi, Qian Huang, Joseph P. Vacca, Harold G. Selnick, Beth Pietrak, Daria J. Hazuda, Amy S. Espeseth, Ming-Chih Crouthamel, Philippe G. Nantermet
المصدر: Journal of medicinal chemistry. 49(25)
مصطلحات موضوعية: chemistry.chemical_classification, Models, Molecular, Oxadiazoles, Aniline Compounds, Molecular model, biology, medicine.drug_class, Isostere, Chemistry, Stereochemistry, Carboxamide, Crystallography, X-Ray, Enzyme, Enzyme inhibitor, Drug Discovery, Hydrolase, medicine, biology.protein, Amyloid precursor protein, Molecular Medicine, Amyloid Precursor Protein Secretases, Amyloid precursor protein secretase
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65e4f41821f47943bc3fa2b30d77fe30Test
https://pubmed.ncbi.nlm.nih.gov/17149856Test -
5
المؤلفون: Timothy J. Allison, Beth Pietrak, Craig A. Coburn, Eric A. Price, Janet Lineberger, Samuel L. Graham, M. Katharine Holloway, Michelle Crouthamel, Adam J. Simon, Daria J. Hazuda, Guoxin Wu, Qian Huang, Joseph P. Vacca, Lixia Jin, Amy S. Espeseth, Sethu Sankaranarayanan, Sanjeev Munshi, Joan D. Ellis, Shawn J. Stachel
المصدر: Journal of medicinal chemistry. 49(21)
مصطلحات موضوعية: Macrocyclic Compounds, Stereochemistry, Molecular Conformation, Phthalic Acids, Stereoisomerism, Chemical synthesis, Mice, Structure-Activity Relationship, In vivo, Drug Discovery, Amyloid precursor protein, Structure–activity relationship, Animals, Protease Inhibitors, Tissue Distribution, chemistry.chemical_classification, Amyloid beta-Peptides, biology, Chemistry, Brain, Biological activity, Amides, Enzyme, Biochemistry, Enzyme inhibitor, Blood-Brain Barrier, biology.protein, Molecular Medicine, Amyloid Precursor Protein Secretases
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::843d6e6a1382fde6708e6a1e2a31bfe3Test
https://pubmed.ncbi.nlm.nih.gov/17034118Test -
6
المؤلفون: Adel M. Naylor-Olsen, Melissa S. Egbertson, Tran Lekhanh O, Thorsten E. Fisher, Kara A. Stillmock, Joseph P. Vacca, M. Katharine Holloway, Steven D. Young, James P. Guare, Peter J. Felock, Vanessa E. Grey, H. Marie Langford, Mark Embrey, John S. Wai, Linghang Zhuang, Daria J. Hazuda, Abigail Wolfe, Payne Linda S, William A. Schleif, Jeffrey Y. Melamed, Lori J. Gabryelski
المصدر: Journal of medicinal chemistry. 43(26)
مصطلحات موضوعية: biology, Aryl, HIV, biology.organism_classification, Nucleotidyltransferase, Virus Replication, Virology, Virus, In vitro, Integrase, Cell Line, chemistry.chemical_compound, Butyrates, Structure-Activity Relationship, chemistry, Viral replication, Enzyme inhibitor, Drug Discovery, Lentivirus, biology.protein, Molecular Medicine, Humans, HIV Integrase Inhibitors
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c145842551cba722b2a7f1512b450a5Test
https://pubmed.ncbi.nlm.nih.gov/11150161Test -
7دورية أكاديمية
المؤلفون: Izzat T. Raheem, Abbas M. Walji, Daniel Klein, John M. Sanders, David A. Powell, Pravien Abeywickrema, Guillaume Barbe, Amrith Bennet, Sophie−Dorothee Clas, David Dubost, Mark Embrey, Jay Grobler, MichaelJ. Hafey, Timothy J. Hartingh, Daria J. Hazuda, Michael D. Miller, KeithP. Moore, Natasa Pajkovic, Sangita Patel, Vanessa Rada
المصدر: Journal of Medicinal Chemistry; Oct2015, Vol. 58 Issue 20, p8154-8165, 12p
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8دورية أكاديمية
المؤلفون: Vincenzo Summa, Alessia Petrocchi, Fabio Bonelli, Benedetta Crescenzi, Monica Donghi, Marco Ferrara, Fabrizio Fiore, Cristina Gardelli, Odalys Gonzalez Paz, Daria J. Hazuda, Philip Jones, Olaf Kinzel, Ralph Laufer, Edith Monteagudo, Ester Muraglia, Emanuela Nizi, Federica Orvieto, Paola Pace, Giovanna Pescatore, Rita Scarpelli
المصدر: Journal of Medicinal Chemistry; Aug2008, Vol. 51 Issue 18, p5843-5855, 13p