دورية أكاديمية

Discovery of the Irreversible Covalent FGFR Inhibitor 8-(3-(4-Acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (PRN1371) for the Treatment of Solid Tumors.

التفاصيل البيبلوغرافية
العنوان: Discovery of the Irreversible Covalent FGFR Inhibitor 8-(3-(4-Acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (PRN1371) for the Treatment of Solid Tumors.
المؤلفون: Brameld, Ken A., Owens, Timothy D., Verner, Erik, Venetsanakos, Eleni, Bradshaw, J. Michael, Phan, Vernon T., Tam, Danny, Leung, Kwan, Jin Shu, LaStant, Jacob, Loughhead, David G., Ton, Tony, Karr, Dane E., Gerritsen, Mary E., Goldstein, David M., Funk, Jens Oliver
المصدر: Journal of Medicinal Chemistry; 8/10/2017, Vol. 60 Issue 15, p6516-6527, 12p
قاعدة البيانات: Supplemental Index
الوصف
تدمد:00222623
DOI:10.1021/acs.jmedchem.7b00360