يعرض 1 - 10 نتائج من 20 نتيجة بحث عن '"CCR5 receptor antagonist"', وقت الاستعلام: 0.74s تنقيح النتائج
  1. 1
    A 'Two-Birds-One-Stone' Approach toward the Design of Bifunctional Human Immunodeficiency Virus Type 1 Entry Inhibitors Targeting the CCR5 Coreceptor and gp41 N-Terminal Heptad Repeat Region

    المؤلفون: Yang Liu, Lu Lu, Chao Wang, Xinling Wang, Jing Pu, Jiahui Li, Shibo Jiang, Qing X. Li, Huan Wang

    المصدر: Journal of Medicinal Chemistry. 64:11460-11471

    مصطلحات موضوعية: Receptors, CCR5, Anti-HIV Agents, viruses, Peptide, CCR5 receptor antagonist, Gp41, Structure-Activity Relationship, Chimera (genetics), chemistry.chemical_compound, Viral envelope, Drug Discovery, Humans, Bifunctional, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, virus diseases, Virus Internalization, Virology, HIV Envelope Protein gp41, Heptad repeat, chemistry, Drug Design, CCR5 Receptor Antagonists, HIV-1, Molecular Medicine, Pharmacophore

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d036ce3d5a8e4220a2f31260dce28780Test
    https://doi.org/10.1021/acs.jmedchem.1c00781Test


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  2. 2
    Structure-Based Design of 1-Heteroaryl-1,3-propanediamine Derivatives as a Novel Series of CC-Chemokine Receptor 5 Antagonists

    المؤلفون: Yong-Tang Zheng, Hong Liu, Huan Chen, Xin Xie, Jiang Wang, Rong-Hua Luo, Ya Zhu, Liu-Meng Yang, Hualiang Jiang, Peng Panfeng, Jian Li, Beili Wu, Zhi-Long Wang, Liang Chen

    المصدر: Journal of medicinal chemistry. 61(21)

    مصطلحات موضوعية: 0301 basic medicine, Drug, Models, Molecular, Receptors, CCR5, Anti-HIV Agents, Protein Conformation, media_common.quotation_subject, CCR5 receptor antagonist, Diamines, 01 natural sciences, Cell Line, 03 medical and health sciences, chemistry.chemical_compound, Pharmacokinetics, Drug Discovery, Potency, Animals, Humans, Cytotoxicity, Maraviroc, media_common, 010405 organic chemistry, virus diseases, Combinatorial chemistry, In vitro, 0104 chemical sciences, Bioavailability, 030104 developmental biology, chemistry, Drug Design, CCR5 Receptor Antagonists, Molecular Medicine

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::959250b73ce539bfe53840e6ab34e317Test
    https://pubmed.ncbi.nlm.nih.gov/30234300Test


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  3. 3
    Function-Oriented Development of CXCR4 Antagonists as Selective Human Immunodeficiency Virus (HIV)-1 Entry Inhibitors

    المؤلفون: Chuan Jen Wang, Amit A. Sadani, Hsin Pang Hsieh, Elizabeth A. Gullen, Yung-Chi Cheng, Chia-Yi Cheng, Yun Chen Tien, Jing Ma, Ming Chen Chou, Chun-Ping Chang, Yi Yu Ke, Chen Fu Lo, Lun K. Tsou, Tsung Chih Hsieh, Jiing Jyh Jan, Jen Shin Song, Yu Wei Liu, Ying Chieh Wong, Chia Hua Tsai, Chien Huang Wu, Kak Shan Shia

    المصدر: Journal of Medicinal Chemistry. 58:1452-1465

    مصطلحات موضوعية: Male, Receptors, CXCR4, HIV Infections, Microbial Sensitivity Tests, CCR5 receptor antagonist, Molecular Dynamics Simulation, Pharmacology, V3 loop, CXCR4, Article, Cell Line, Mice, Structure-Activity Relationship, Chemokine receptor, HIV Fusion Inhibitors, Viral entry, Drug Discovery, Animals, Humans, Structure–activity relationship, CXCR4 antagonist, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Virus Internalization, Entry into host, Mice, Inbred C57BL, CCR5 Receptor Antagonists, HIV-1, Molecular Medicine

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa19206a3e5b5af84e76abcf8c074d1bTest
    https://doi.org/10.1021/jm501772wTest


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  4. 4
    Inhibition of Inflammatory and Neuropathic Pain by Targeting a Mu Opioid Receptor/Chemokine Receptor5 Heteromer (MOR-CCR5)

    المؤلفون: Eyup Akgün, Mary M. Lunzer, Yoshikazu Watanabe, Michael D. Powers, Yuk Y. Sham, Philip S. Portoghese, Muhammad I. Javed

    المصدر: Journal of medicinal chemistry. 58(21)

    مصطلحات موضوعية: Agonist, Male, Models, Molecular, Chemokine, Receptors, CCR5, medicine.drug_class, Heteromer, Receptors, Opioid, mu, CCR5 receptor antagonist, Pharmacology, Article, Chemokine receptor, Mice, Drug Discovery, medicine, Animals, Humans, Molecular Targeted Therapy, Inflammation, Analgesics, biology, Chemistry, HEK293 Cells, Opioid, CCR5 Receptor Antagonists, Chronic Disease, Morphine, biology.protein, Molecular Medicine, Neuralgia, μ-opioid receptor, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc494d001cd480c852bd920b3c28200aTest
    https://pubmed.ncbi.nlm.nih.gov/26451468Test


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  5. 5
    An Imidazopiperidine Series of CCR5 Antagonists for the Treatment of HIV: The Discovery of N-{(1S)-1-(3-Fluorophenyl)-3-[(3-endo)-3-(5-isobutyryl-2-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}acetamide (PF-232798)

    المؤلفون: Manos Perros, David C. Pryde, Rob Webster, Francesca Perruccio, Michelle Y. Platts, Rhys M. Jones, Deborah Rodrigues, David V. Batchelor, David Ellis, Donald Stuart Middleton, David R. Fenwick, Patrick Dorr, Stupple Paul Anthony, Mike Westby, Anthony Wood, Helen J. Mason, Nicholas Smith, Martin Corless, Sebastien Galan, Peter T. Stephenson

    المصدر: Journal of Medicinal Chemistry. 54:67-77

    مصطلحات موضوعية: biology, Chemistry, Stereochemistry, Chemokine receptor CCR5, hERG, Antagonist, Stereoisomerism, CCR5 receptor antagonist, Pharmacology, chemistry.chemical_compound, Drug Discovery, biology.protein, Molecular Medicine, Structure–activity relationship, Acetamide, Maraviroc

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::25d25891e80de63ffeeae1e4b692e76dTest
    https://doi.org/10.1021/jm100978nTest


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  6. 6
    Discovery of a Piperidine-4-carboxamide CCR5 Antagonist (TAK-220) with Highly Potent Anti-HIV-1 Activity

    المؤلفون: Katsunori Takashima, Yuji Iizawa, Naoyuki Kanzaki, Youichi Nishikawa, Masanori Baba, Shin-Ichi Niwa, Shinichi Imamura, Yoshihiro Sugihara, Takashi Ichikawa

    المصدر: Journal of Medicinal Chemistry. 49:2784-2793

    مصطلحات موضوعية: Receptors, CCR5, Anti-HIV Agents, medicine.drug_class, Stereochemistry, Carboxamide, CCR5 receptor antagonist, Peripheral blood mononuclear cell, Cell Line, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Piperidines, Pharmacokinetics, Cricetinae, Chlorocebus aethiops, Drug Discovery, medicine, Animals, Humans, Moiety, Potency, Molecular Structure, Lipid bilayer fusion, chemistry, CCR5 Receptor Antagonists, Molecular Medicine, Piperidine

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8316fb31b25d5d6ef25cf70fad177ac5Test
    https://doi.org/10.1021/jm051034qTest


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  7. 7
    Highly Potent and Orally Active CCR5 Antagonists as Anti-HIV-1 Agents: Synthesis and Biological Activities of 1-Benzazocine Derivatives Containing a Sulfoxide Moiety

    المؤلفون: Mitsuru Shiraishi, Katsuji Aikawa, Yuji Iizawa, Masanori Baba, Katsunori Takashima, Yoji Kuze, Naoki Miyamoto, Naoyuki Kanzaki, Masaki Seto, Yoshio Aramaki

    المصدر: Journal of Medicinal Chemistry. 49:2037-2048

    مصطلحات موضوعية: Male, Anti-HIV Agents, Stereochemistry, Administration, Oral, Biological Availability, CCR5 receptor antagonist, HIV Envelope Protein gp120, In Vitro Techniques, Virus Replication, Membrane Fusion, Benzazocine, Cell Line, chemistry.chemical_compound, Dogs, Chlorocebus aethiops, Drug Discovery, Animals, Humans, Moiety, Potency, Ligand binding assay, Imidazoles, Chemical modification, Stereoisomerism, Sulfoxide, Azocines, Rats, Bioavailability, Macaca fascicularis, chemistry, Sulfoxides, CCR5 Receptor Antagonists, HIV-1, Leukocytes, Mononuclear, Molecular Medicine, Half-Life

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d22a8c010c13bcf7fcf740e76eca238Test
    https://doi.org/10.1021/jm0509703Test


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  8. 8
    Piperazine-Based CCR5 Antagonists as HIV-1 Inhibitors. IV. Discovery of 1-[(4,6-Dimethyl-5-pyrimidinyl)carbonyl]- 4-[4-{2-methoxy-1(R)-4-(trifluoromethyl)phenyl}ethyl-3(S)-methyl-1-piperazinyl]- 4-methylpiperidine (Sch-417690/Sch-D), a Potent, Highly Selective, and Orally Bioavailable CCR5 Antagonist

    المؤلفون: Marc A. Labroli, Geoffrey B. Varty, Dennis V. Nazareno, Stuart W. McCombie, Steensma Ruo, Julie M. Strizki, Bahige M. Baroudy, Jayaram R. Tagat, Kathleen Cox, Robert W. Watkins, Jean E. Lachowicz, Yushi Xiao

    المصدر: Journal of Medicinal Chemistry. 47:2405-2408

    مصطلحات موضوعية: Potassium Channels, Anti-HIV Agents, medicine.drug_class, Stereochemistry, Substituent, Administration, Oral, Biological Availability, Carboxamide, CCR5 receptor antagonist, In Vitro Techniques, Chemical synthesis, Piperazines, Structure-Activity Relationship, chemistry.chemical_compound, Piperidines, Drug Discovery, polycyclic compounds, medicine, Animals, Humans, Structure–activity relationship, heterocyclic compounds, Cation Transport Proteins, Trifluoromethyl, organic chemicals, Brain, Stereoisomerism, Ether-A-Go-Go Potassium Channels, Rats, Macaca fascicularis, Piperazine, Pyrimidines, chemistry, Potassium Channels, Voltage-Gated, CCR5 Receptor Antagonists, HIV-1, Leukocytes, Mononuclear, Molecular Medicine, Selectivity, Digestive System

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb2f7d87ed1298266b41ff938e8e90d6Test
    https://doi.org/10.1021/jm0304515Test


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  9. 9
    Generation of Predictive Pharmacophore Models for CCR5 Antagonists: Study with Piperidine- and Piperazine-Based Compounds as a New Class of HIV-1 Entry Inhibitors

    المؤلفون: Asim K. Debnath

    المصدر: Journal of Medicinal Chemistry. 46:4501-4515

    مصطلحات موضوعية: Models, Molecular, Molecular model, Anti-HIV Agents, Stereochemistry, Molecular Conformation, Human immunodeficiency virus (HIV), CCR5 receptor antagonist, medicine.disease_cause, Catalysis, Piperazines, Structure-Activity Relationship, chemistry.chemical_compound, Piperidines, Drug Discovery, medicine, Training set, Kinetics, Piperazine, chemistry, Test set, CCR5 Receptor Antagonists, HIV-1, Molecular Medicine, Piperidine, Pharmacophore, Algorithms

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2315f9471d83ed7783bf543d03623b10Test
    https://doi.org/10.1021/jm030265zTest


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  10. 10
    Piperazine-Based CCR5 Antagonists as HIV-1 Inhibitors. II. Discovery of 1-[(2,4-Dimethyl-3-pyridinyl)carbonyl]-4- methyl-4-[3(S)-methyl-4-[1(S)-[4-(trifluoro- methyl)phenyl]ethyl]-1-piperazinyl]- piperidine N1-Oxide (Sch-350634), an Orally Bioavailable, Potent CCR5 Antagonist

    المؤلفون: Michael G. Murray, Bernard R. Neustadt, Julie M. Strizki, Sue-Ing Lin, Nicole Vantuno, Lisa Wojcik, Jayaram R. Tagat, Kathleen Cox, and Bahige M. Baroudy, Steensma Ruo, Dennis V. Nazareno, Stuart W. McCombie, Serena Xu

    المصدر: Journal of Medicinal Chemistry. 44:3343-3346

    مصطلحات موضوعية: Chemistry, Stereochemistry, Antagonist, virus diseases, CCR5 receptor antagonist, Chemical synthesis, Bioavailability, chemistry.chemical_compound, Piperazine, Drug Discovery, Muscarinic acetylcholine receptor, Molecular Medicine, Structure–activity relationship, Piperidine

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::13d3fd3d509d230c7eb1b4a8a60a7827Test
    https://doi.org/10.1021/jm0155401Test


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