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1دورية أكاديمية
المؤلفون: Tang, Wei, Martásek, Pavel, Roman, Linda, Poulos, Thomas, Silverman, Richard, Kang, Soosung, Li, Huiying
المصدر: Journal of Medicinal Chemistry. 58(14)
مصطلحات موضوعية: Aminopyridines, Animals, Biological Availability, Enzyme Inhibitors, Humans, Male, Mice, Models, Molecular, Nitric Oxide Synthase Type I, Protein Conformation, Rats, Structure-Activity Relationship, Substrate Specificity
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/8wb4b6jcTest
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2دورية أكاديمية
المؤلفون: Lee, Kin Sing Stephen, Liu, Jun-Yan, Wagner, Karen M, Pakhomova, Svetlana, Dong, Hua, Morisseau, Christophe, Fu, Samuel H, Yang, Jun, Wang, Peng, Ulu, Arzu, Mate, Christina A, Nguyen, Long V, Hwang, Sung Hee, Edin, Matthew L, Mara, Alexandria A, Wulff, Heike, Newcomer, Marcia E, Zeldin, Darryl C, Hammock, Bruce D
المصدر: Journal of Medicinal Chemistry. 57(16)
مصطلحات موضوعية: Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Peripheral Neuropathy, Pain Research, Neurodegenerative, Chronic Pain, Diabetes, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Metabolic and endocrine, Administration, Oral, Amines, Analgesics, Animals, Biological Availability, Chemistry Techniques, Synthetic, Crystallography, X-Ray, Cyclohexanecarboxylic Acids, Diabetes Mellitus, Type 1, Diabetic Neuropathies, Drug Design, Enzyme Inhibitors, Epoxide Hydrolases, Gabapentin, Humans, Male, Mice, Molecular Targeted Therapy, Neuralgia, Rats, Sprague-Dawley, Solubility, Structure-Activity Relationship, Time Factors, gamma-Aminobutyric Acid, Medicinal and Biomolecular Chemistry, Organic Chemistry, Pharmacology and Pharmaceutical Sciences, Medicinal & Biomolecular Chemistry, Pharmacology and pharmaceutical sciences, Medicinal and biomolecular chemistry, Organic chemistry
وصف الملف: application/pdf
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3دورية أكاديمية
المؤلفون: Calvet, Claudia M, Vieira, Debora F, Choi, Jun Yong, Kellar, Danielle, Cameron, Michael D, Siqueira-Neto, Jair Lage, Gut, Jiri, Johnston, Jonathan B, Lin, Li, Khan, Susan, McKerrow, James H, Roush, William R, Podust, Larissa M
المصدر: Journal of Medicinal Chemistry. 57(16)
مصطلحات موضوعية: Orphan Drug, Infectious Diseases, Rare Diseases, Vector-Borne Diseases, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Infection, Good Health and Well Being, 14-alpha Demethylase Inhibitors, 4-Aminopyridine, Administration, Oral, Animals, Biological Availability, Chagas Disease, Chemistry Techniques, Synthetic, Crystallography, X-Ray, Cyclodextrins, Disease Models, Animal, Dose-Response Relationship, Drug, Female, Humans, Luciferases, Firefly, Mice, Organisms, Genetically Modified, Polyethylene Glycols, Stearates, Structure-Activity Relationship, Tissue Distribution, Trypanocidal Agents, Trypanosoma cruzi, Medicinal and Biomolecular Chemistry, Organic Chemistry, Pharmacology and Pharmaceutical Sciences, Medicinal & Biomolecular Chemistry
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/74z1t9b3Test
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4دورية أكاديمية
المؤلفون: Lou, Kevin, Yao, Yuemang, Hoye, Adam T, James, Michael J, Cornec, Anne-Sophie, Hyde, Edward, Gay, Bryant, Lee, Virginia M-Y, Trojanowski, John Q, Smith, Amos B, Brunden, Kurt R, Ballatore, Carlo
المصدر: Journal of Medicinal Chemistry. 57(14)
مصطلحات موضوعية: Aging, Neurodegenerative, Acquired Cognitive Impairment, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Alzheimer's Disease, Neurosciences, Dementia, Brain Disorders, Aetiology, 2.1 Biological and endogenous factors, Neurological, Administration, Oral, Alzheimer Disease, Animals, Biological Availability, Brain, Cell Line, Humans, Mice, Microtubules, Molecular Structure, Pyrimidines, Tauopathies, Medicinal and Biomolecular Chemistry, Organic Chemistry, Pharmacology and Pharmaceutical Sciences, Medicinal & Biomolecular Chemistry
الوصول الحر: https://escholarship.org/uc/item/63x1z7w7Test
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5
المؤلفون: Xufen Yu, Jia Xu, Yudao Shen, Kaitlyn M. Cahuzac, Kwang-su Park, Brandon Dale, Jing Liu, Ramon E. Parsons, Jian Jin
المصدر: J Med Chem
مصطلحات موضوعية: Male, Proteasome Endopeptidase Complex, Dose-Response Relationship, Drug, Ubiquitin, Biological Availability, Mice, Nude, Antineoplastic Agents, Xenograft Model Antitumor Assays, Article, Mice, Structure-Activity Relationship, Pyrimidines, Cell Line, Tumor, PC-3 Cells, Proteolysis, Drug Discovery, Animals, Humans, Molecular Medicine, Pyrroles, Protein Kinase Inhibitors, Proto-Oncogene Proteins c-akt, Cell Division, Tumor Stem Cell Assay
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::339785175c1d33f70c781f6819c2f890Test
https://doi.org/10.1021/acs.jmedchem.1c02165Test -
6
المؤلفون: Li Zhang, Chen Cheng, Jing Li, Lili Wang, Alexander A. Chumanevich, Donald C. Porter, Aleksei Mindich, Svetlana Gorbunova, Igor B. Roninson, Mengqian Chen, Campbell McInnes
المصدر: J Med Chem
مصطلحات موضوعية: Models, Molecular, Mice, Inbred BALB C, Leukemia, Molecular Structure, Biological Availability, Antineoplastic Agents, Cyclin-Dependent Kinase 8, Xenograft Model Antitumor Assays, Article, Cyclin-Dependent Kinases, Substrate Specificity, Molecular Docking Simulation, Mice, Structure-Activity Relationship, Cell Line, Tumor, Colonic Neoplasms, Drug Discovery, Quinolines, Animals, Humans, Molecular Medicine, Protein Kinase Inhibitors
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f80e251b7f48b57b09fb5e471f12c0b5Test
https://doi.org/10.1021/acs.jmedchem.1c01951Test -
7
المؤلفون: Xiong Xie, Yu-Gui Zheng, Huan Chen, Jian Li, Rong-Hua Luo, Liang Chen, Chang-Bo Zheng, Shurui Zhang, Panfeng Peng, Dakota Ma, Liu-Meng Yang, Yong-Tang Zheng, Hong Liu, Jiang Wang
المصدر: Journal of medicinal chemistry. 65(24)
مصطلحات موضوعية: Receptors, CCR5, Anti-HIV Agents, Biological Availability, HIV Infections, Triazoles, Rats, Maraviroc, Rats, Sprague-Dawley, Cyclohexanes, Drug Discovery, CCR5 Receptor Antagonists, HIV-1, Molecular Medicine, Animals, Tropanes
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d269f8165afa4909ec27c3f7aa01de1bTest
https://pubmed.ncbi.nlm.nih.gov/36472561Test -
8
المؤلفون: Li Wang, Yudao Shen, Jian Jin, Jia Xu, Kaitlyn M. Cahuzac, Xian Chen, Xufen Yu, Ramon Parsons, Jing Liu, Ling Xie
المصدر: J Med Chem
مصطلحات موضوعية: Biological Availability, Article, Piperazines, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, Animals, Humans, Phosphatidylinositol, Protein Kinase Inhibitors, Protein kinase B, PI3K/AKT/mTOR pathway, biology, Kinase, Cereblon, Proteolysis targeting chimera, Ubiquitin ligase, Cell biology, Pyrimidines, chemistry, Drug Design, biology.protein, Molecular Medicine, Signal transduction, Proto-Oncogene Proteins c-akt
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::282a33b7e211ac3e81e57d9f184f81e4Test
https://doi.org/10.1021/acs.jmedchem.1c01476Test -
9
المؤلفون: Fulai Yang, Xiaojin Zhang, Simeng Liu, Le Yang, Xiang Li, Chenyang Wu, Xiaoqian Bao, Yancheng Yu, Quanwei Yu, Kaijun Su, Zhihong Li
المصدر: Journal of Medicinal Chemistry. 64:17384-17402
مصطلحات موضوعية: Agonist, Anemia, medicine.drug_class, Administration, Oral, Biological Availability, Pharmacology, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, Pharmacokinetics, In vivo, Drug Discovery, Basic Helix-Loop-Helix Transcription Factors, medicine, Animals, Humans, Doxorubicin, Renal Insufficiency, Chronic, Zebrafish, Chemistry, Prolyl-Hydroxylase Inhibitors, medicine.disease, Rats, Bioavailability, Hypoxia-inducible factors, Erythropoietin, Molecular Medicine, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d5b43ade2d5e351a7c78193b4fe7ddeTest
https://doi.org/10.1021/acs.jmedchem.1c01479Test -
10
المؤلفون: Thomas J. Tucker, Nianyu Li, Scott P. Salowe, Harold B. Wood, Danila Branca, Alan S. Bass, Rupesh P. Amin, BethAnn Murphy, Aurash Shahripour, Angela Kerekes, Abbas Walji, Nicole Buist, Jeffrey T. Kuethe, Huaibing He, Rodger Tracy, Kenneth A. Koeplinger, Weixun Wang, Bhavana Bhatt, Candice Alleyne, Sookhee Ha, Douglas G. Johns, Elisabetta Bianchi, Chengwei Wu, Peter Orth, Tjerk Bueters, Yusheng Xiong, Hratch J. Zokian, Michael J. Hafey, Mark W. Embrey, John Higgins
المصدر: Journal of Medicinal Chemistry. 64:16770-16800
مصطلحات موضوعية: chemistry.chemical_classification, Molecular Structure, biology, PCSK9, PCSK9 Inhibitors, Administration, Oral, Biological Availability, Peptide, Pharmacology, Crystallography, X-Ray, Proprotein convertase, Peptides, Cyclic, Rats, Bioavailability, Macaca fascicularis, Structure-Activity Relationship, chemistry, Drug Discovery, biology.protein, Animals, Molecular Medicine, Kexin, Dosing, Antibody, Tricyclic
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d01cd83054fdae5294b50a6dbca9f594Test
https://doi.org/10.1021/acs.jmedchem.1c01599Test