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1
المؤلفون: Ann M. Decker, Catherine M. Kotz, Vijayakumar Mavanji, Tiffany L. Langston, Dehui Zhang, Yanan Zhang, Danni L. Harris, David A. Perrey
المصدر: J Med Chem
مصطلحات موضوعية: Male, Agonist, medicine.drug_class, medicine.medical_treatment, Intraperitoneal injection, CHO Cells, Molecular Dynamics Simulation, Pharmacology, 01 natural sciences, Article, Mice, Structure-Activity Relationship, 03 medical and health sciences, Cricetulus, Orexin Receptors, Drug Discovery, medicine, Animals, Structure–activity relationship, Wakefulness, 030304 developmental biology, Sulfonamides, 0303 health sciences, Molecular Structure, biology, Chemistry, biology.organism_classification, medicine.disease, Small molecule, 0104 chemical sciences, Orexin, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, Molecular Medicine, Female, Sleep, Narcolepsy
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::931ff980a0192e08e857b44e3b894b07Test
https://doi.org/10.1021/acs.jmedchem.1c00841Test -
2
المؤلفون: Jyrki P. Kukkonen, Lasse Karhu, Ainoleena Turku, Teppo O. Leino, Henri Xhaard, Alexandre Borrel
المصدر: Journal of Medicinal Chemistry. 59:8263-8275
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Agonist, medicine.drug_class, Stereochemistry, Pharmacology, Ligands, Cell Line, 03 medical and health sciences, Orexin Receptors, Drug Discovery, medicine, Humans, Receptor, Chemistry, Drug discovery, Small molecule, Orexin receptor, 3. Good health, 030104 developmental biology, Docking (molecular), Molecular Medicine, Calcium, Orexin Receptor Antagonists, Signal transduction, Pharmacophore
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e65801876bf7c308b278c37c4dc8fe34Test
https://doi.org/10.1021/acs.jmedchem.6b00333Test -
3
المؤلفون: Hideaki Fujii, Yasuhiro Ogawa, Hiroshi Nagase, Noriki Kutsumura, Tsuyoshi Saitoh, Daisuke Kuroda, Takashi Nagahara, Hidetoshi Kumagai, Yoko Irukayama-Tomobe, Masashi Yanagisawa, Hiroaki Gouda
المصدر: Journal of Medicinal Chemistry. 58:7931-7937
مصطلحات موضوعية: Models, Molecular, Agonist, medicine.medical_specialty, Cataplexy, medicine.drug_class, Neuropeptide, CHO Cells, Pharmacology, Small Molecule Libraries, Structure-Activity Relationship, Cricetulus, X-Ray Diffraction, Orexin Receptors, Cell Line, Tumor, Cricetinae, Internal medicine, Drug Discovery, medicine, Animals, Humans, Receptor, Narcolepsy, Sulfonamides, biology, Chemistry, Hydrogen Bonding, biology.organism_classification, medicine.disease, Orexin receptor, High-Throughput Screening Assays, Endocrinology, Drug Design, Benzamides, Molecular Medicine, Calcium, Wakefulness, medicine.symptom
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4999ae7e918cd996560215c930bc2faeTest
https://doi.org/10.1021/acs.jmedchem.5b00988Test -
4
المؤلفون: Sujin Yun, Michael A. Letavic, Neelakandha S. Mani, Kiev S. Ly, Tatiana Koudriakova, Nicholas I. Carruthers, Brock T. Shireman, Brian Lord, Lana K. Young, Daniel J. Pippel, Christine Dugovic, Pascal Bonaventure, Timothy W. Lovenberg, Diane Nepomuceno, Michele C. Rizzolio, Jonathan Shelton, Chandra R Shah
المصدر: Journal of Medicinal Chemistry. 58:5620-5636
مصطلحات موضوعية: Male, Clinical Trials as Topic, Orexins, Chemistry, Primary Insomnia, Neuropeptides, Intracellular Signaling Peptides and Proteins, Pharmacology, Rats, Substrate Specificity, Orexin, Clinical trial, Structure-Activity Relationship, Dogs, Orexin Receptors, Sleep Initiation and Maintenance Disorders, mental disorders, Drug Discovery, Animals, Humans, Molecular Medicine, Structure–activity relationship, Substrate specificity, Pyrroles, Tissue distribution
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d0e0c122be60d371d648b1792c44cfbTest
https://doi.org/10.1021/acs.jmedchem.5b00742Test -
5
المؤلفون: Noriki Kutsumura, Tsuyoshi Saitoh, Masahiro Yata, Yasuyuki Nagumo, Naoshi Yamamoto, Shigeto Hirayama, Yukiko Ishikawa, Daisuke Kuroda, Sayaka Ohrui, Yoko Irukayama-Tomobe, Hiroaki Gouda, Masashi Yanagisawa, Yurie Watanabe, Hiroshi Nagase, Yasuhiro Ogawa, Takahiro Okada
المصدر: Journal of medicinal chemistry. 60(3)
مصطلحات موضوعية: 0301 basic medicine, Morphinan, Stereochemistry, medicine.drug_class, Pharmacology, Ligands, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Opioid receptor, Orexin Receptors, Drug Discovery, medicine, Animals, Spiro Compounds, Receptor, Antagonist, Ligand (biochemistry), Orexin, 030104 developmental biology, Opioid, chemistry, Morphinans, Molecular Medicine, 030217 neurology & neurosurgery, Nalfurafine, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e39b30207ad5505c0145a54bf64419f2Test
https://pubmed.ncbi.nlm.nih.gov/28051300Test -
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المؤلفون: Chetan Pandit, Christine E. Gee, Daniel Hoyer, Vinod D. Chaudhari, Grit Laue, Juergen Wagner, Laura H. Jacobson, Dirk Behnke, Claudia Betschart, Simona Cotesta, Sangamesh Badiger, Samuel Hintermann, Markus Fendt, Silvio Ofner
المصدر: Journal of Medicinal Chemistry. 56:7590-7607
مصطلحات موضوعية: Male, Indoles, Sleep induction, Primary Insomnia, Motor Activity, Pharmacology, Doras, Non-rapid eye movement sleep, Mice, Structure-Activity Relationship, Quinoxalines, Sleep Initiation and Maintenance Disorders, mental disorders, Drug Discovery, medicine, Animals, Spiro Compounds, Sleep Stages, biology, Electromyography, Chemistry, Suvorexant, Electroencephalography, Stereoisomerism, Azepines, Triazoles, biology.organism_classification, Orexin receptor, Mice, Inbred C57BL, Pyrimidines, Molecular Medicine, Orexin Receptor Antagonists, Almorexant, Sleep, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48dc21e46c9f923dccf5394833956e52Test
https://doi.org/10.1021/jm4007627Test -
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المؤلفون: Brian P. Gilmour, David A. Perrey, Yanan Zhang, Jun-Xu Li, Nadezhda German, Brian F. Thomas, Danni L. Harris
المصدر: Journal of Medicinal Chemistry. 56:6901-6916
مصطلحات موضوعية: Receptors, Neuropeptide, Chemistry, Stereochemistry, Pharmacology, Article, Orexin receptor, Rats, Receptors, G-Protein-Coupled, Orexin, Structure-Activity Relationship, chemistry.chemical_compound, Cocaine, Orexin Receptors, Tetrahydroisoquinolines, Drug Discovery, Animals, Molecular Medicine, Structure–activity relationship, Potency, Pharmacophore, Antagonism, Receptor, Acetamide
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b8d7b1712e53b4bfea56e3c2f8dcc45Test
https://doi.org/10.1021/jm400720hTest -
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المؤلفون: Michiyuki Suzuki, Takashi Doko, Keiichi Sorimachi, Toshiaki Tanaka, Carsten T. Beuckmann, Yoshimitsu Naoe, Masahiro Yonaga, Yu Yoshida, Taro Terauchi, Shunsuke Ozaki, Takemura Ayumi, Takashi Ueno, Fumihiro Ozaki
المصدر: Journal of medicinal chemistry. 58(11)
مصطلحات موضوعية: Cyclopropanes, Male, Models, Molecular, medicine.medical_specialty, Lemborexant, Administration, Oral, Aminopyridines, Pharmacology, Mice, Structure-Activity Relationship, Orexin Receptors, Internal medicine, mental disorders, Drug Discovery, medicine, Structure–activity relationship, Animals, Humans, Receptor, Cells, Cultured, Molecular Structure, Chemistry, Drug discovery, digestive, oral, and skin physiology, Antagonist, Amides, Orexin receptor, Orexin, Mice, Inbred C57BL, Endocrinology, Pyrimidines, nervous system, Drug Design, Microsomes, Liver, Molecular Medicine, Calcium, Orexin Receptor Antagonists, Orexin antagonist, psychological phenomena and processes
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::644397831fc17d8ca108130834337705Test
https://pubmed.ncbi.nlm.nih.gov/25953512Test