التفاصيل البيبلوغرافية
| العنوان: |
Human insulin versus porcine insulin in rhesus monkeys with diabetes mellitus. |
| المؤلفون: |
Jin, Xi, Zeng, Li, Zhang, Shuang, He, Sirong, Ren, Yan, Chen, Younan, Wei, Lingling, Wang, Li, Li, Hongxia, Cheng, Jingqiu, Lu, Yanrong |
| المصدر: |
Journal of Medical Primatology; Feb2013, Vol. 42 Issue 1, p1-9, 9p |
| مصطلحات موضوعية: |
TREATMENT of diabetes, INSULIN, LABORATORY monkeys, DRUG administration, DIABETES complications, BLOOD sugar, ISLANDS of Langerhans transplantation, TREATMENT effectiveness |
| مستخلص: |
Background Monkeys with insulin-dependent diabetes are important preclinical animal models for islet transplantation. Exogenous insulin should be administered to achieve good glycemic control and minimize the long-term vascular complications associated with diabetes until the graft function recovered completely. However, the effect of multiple daily injections of porcine or human insulin and the long-term effects of porcine insulin have not been studied in diabetic rhesus monkeys. Methods Diabetic rhesus monkeys, using a 6-month self-control insulin comparison experiment, were used to detect the incidence of adverse events and long-term diabetes complication events after long-term administration of porcine insulin. Results In this study, we found that a 20% higher dose of porcine insulin results in similar glycemic control as the human insulin regimen, and adverse events were seldom reported when porcine insulin was administered. Moreover, long-term injection with porcine insulin could delay the rate and severity of diabetes-related complications. Conclusions Porcine insulin as a competent candidate for regular insulin therapy to maintain blood glucose levels in insulin-dependent diabetic monkeys during preclinical studies of islet transplantation. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
