دورية أكاديمية
The modulating effect of royal jelly consumption against radiation-induced apoptosis in human peripheral blood leukocytes
| العنوان: | The modulating effect of royal jelly consumption against radiation-induced apoptosis in human peripheral blood leukocytes |
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| المؤلفون: | Navid Rafat, Ali Shabestani Monfared, Maryam Shahidi, Tayyeb Allahverdi Pourfallah |
| المصدر: | Journal of Medical Physics, Vol 41, Iss 1, Pp 52-57 (2016) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2016. |
| سنة النشر: | 2016 |
| المجموعة: | LCC:Medical physics. Medical radiology. Nuclear medicine |
| مصطلحات موضوعية: | Apoptosis, comet assay, ionizing radiation, leukocytes, royal jelly, Medical physics. Medical radiology. Nuclear medicine, R895-920 |
| الوصف: | The present work was designed to assess the radioprotective effect of royal jelly (RJ) against radiation-induced apoptosis in human peripheral blood leukocytes. In this study, peripheral blood samples were obtained on days 0, 4, 7, and 14 of the study from six healthy male volunteers taking a 1000 mg RJ capsule orally per day for 14 consecutive days. On each sampling day, all collected whole blood samples were divided into control and irradiated groups which were then exposed to the selected dose of 4 Gy X-ray. Percentage of apoptotic cells (Ap %) was evaluated for all samples immediately after irradiation (Ap0) and also after a 24 h postirradiation incubation at 37°C in 5% CO2 (Ap24) by the use of neutral comet assay. Concerning Ap0, collected data demonstrated that the percentage of apoptotic cells in both control and irradiated groups did not significantly change during the study period. However, with respect to Ap24, the percentage of apoptotic cells in irradiated groups gradually reduced during the experiment, according to which a significant decrease was found after 14 days RJ consumption (P = 0.002). In conclusion, the present study revealed the protective role of 14 days RJ consumption against radiation-induced apoptosis in human peripheral blood leukocytes. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0971-6203 1998-3913 |
| العلاقة: | http://www.jmp.org.in/article.asp?issn=0971-6203;year=2016;volume=41;issue=1;spage=52;epage=57;aulast=RafatTest; https://doaj.org/toc/0971-6203Test; https://doaj.org/toc/1998-3913Test |
| DOI: | 10.4103/0971-6203.177281 |
| الوصول الحر: | https://doaj.org/article/0cd9d54004c94c63a55b9eadadaa6bccTest |
| رقم الانضمام: | edsdoj.0cd9d54004c94c63a55b9eadadaa6bcc |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 09716203 19983913 |
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| DOI: | 10.4103/0971-6203.177281 |