دورية أكاديمية
Serum Klotho as a marker for early diagnosis of acute kidney injury after cardiac surgery
| العنوان: | Serum Klotho as a marker for early diagnosis of acute kidney injury after cardiac surgery |
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| المؤلفون: | Jerin Aleš, Mosa Osama F., Kališnik Jurij M., Žibert Janez, Skitek Milan |
| المصدر: | Journal of Medical Biochemistry, Vol 39, Iss 2, Pp 133-139 (2020) |
| بيانات النشر: | Society of Medical Biochemists of Serbia, Belgrade |
| سنة النشر: | 2020 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | acute kidney injury, cardiac surgery, vreatinine, klotho protein, Biochemistry, QD415-436 |
| الوصف: | Background: Early diagnosis of acute kidney injury (AKI) after cardiac surgery is based on serum creatinine which is neither a specific nor a sensitive biomarker. In our study, we investigated the role of serum Klotho in early prediction of AKI after cardiac surgery using cardiopulmonary bypass (CPB). Methods: The included patients were classified into three groups according to AKI stages using KDIGO criteria. The measurements of creatinine and Klotho levels in serum were performed before surgery, at the end of CPB, 2 hours after the end of CPB, 24 hours and 48 hours postoperatively. Results: Seventy-eight patients were included in the study. A significant increase of creatinine levels (p<0.001) was measured on the first day after the surgery in both AKI groups compared to the non-AKI group. However, a significant difference between AKI-2 and AKI-1 groups (p=0.006) was not measured until the second day after the operation. Using decision trees for classification of patients with a higher or lower risk of AKI we found out that Klotho discriminated between the patients at low risk of developing more severe kidney injury in the first hours after surgery and the patients at high risk better than creatinine. Adding also the early measurements of creatinine in the decision tree model further improved the prediction of AKI. Conclusions: Serum Klotho may be useful to discriminate between the patients at lower and the patients at higher risk of developing severe kidney injury after cardiac surgery using CPB already in the first hours after surgery. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1452-8258 1452-8266 |
| العلاقة: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2020/1452-82582002133J.pdfTest; https://doaj.org/toc/1452-8258Test; https://doaj.org/toc/1452-8266Test; https://doaj.org/article/dfe667b34b444afab94d180dd9ecceceTest |
| الإتاحة: | https://doaj.org/article/dfe667b34b444afab94d180dd9ecceceTest |
| رقم الانضمام: | edsbas.B21EFE92 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14528258 14528266 |
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