التفاصيل البيبلوغرافية
| العنوان: |
CLINICAL BIOCHEMISTRY DATABASE ANALYSIS: A RESTRICTED DIALYSIS COHORT /. |
| المؤلفون: |
Bellini, Martina, Paparella, Paolo |
| المصدر: |
Journal of Medical Biochemistry; 2014, Vol. 33 Issue 2, p162-168, 7p, 7 Charts |
| مصطلحات موضوعية: |
BIOCHEMISTRY databases, FERRITIN, DIALYSIS (Chemistry), BETA 2-microglobulin, HEMOCHROMATOSIS |
| الملخص (بالإنجليزية): |
Background: A retrospective study was undertaken to inves- tigate the biochemistry data of a restricted cohort of dialysis- related arthropathy patients. The aim of our study was to characterize this specific cohort of dialysis patients using a clinical chemistry database analysis. Methods: An elaboration of more than 160,000 items of biochemical data, collected from 2001 to 20|11, was made of 50 patients, 25 with dialysis-related arthropathy and 25 patients asymptomatic for arthropathy. A Student's t-test was applied, considering a P-value less than 0.05 as statistically significant. Results: Significant and relevant unexpected biochemical dif- ferences were found between the two groups of patients. The serum level of p2-microglobulin was similar, while fer- ritin values were significantly higher in symptomatic patients. We excluded the possibility that the ferritin difference between the two groups was due to different iron storage and to an inflammatory profile. Conclusions: The correct use of a biochemical database could permit to identify significant values which must be cor- related with clinical data, but which could be the first step to a wider research. [ABSTRACT FROM AUTHOR] |
| Abstract (Serbian): |
Uvod: Ova retrospektivna studija sprovedena je kako bi se istražili biohemijski podaci ograničene grupe pacijenata sa artropatijom usled dijalize. Cilj studije je da se pomoću ana- lize kliničko-hemijske baze podataka napravi karakterizacija ove specifične grupe pacijenata na dijalizi. Metode: Vise od 160000 stavki obrađeno je u skupu bio- hemijskih podataka sakupljenih izmedu 2001. i 2011. od 50 pacijenata, 25 sa artropatijom usled dijalize i 25 pacijena- ta bez simptoma artropatije. Primenjen je Studentov t-test, a statistički značajnim smatrane su vrednosti P manje od 0,05. Rezultati: Izmedu ove dve grupe pacijenata neočekivano su pronađene značajne i relevantne biohemijske razlike. Se- rumski nivo p2-mikroglobulina bio je sličan, dok su vrednosti feritina kod pacijenata sa ovom bolešću bile značajno vise. Isključena je mogućnost da razlika u feritinu izmedu dve grupe potiče od različitih zaliha gvožđa ili inflamatornog pro- fila. Zaključak: Pravilna upotreba biohemijske baze podataka mogla bi omogućiti identifikaciju značajnih vrednosti koje moraju korelisati sa kliničkim podacima, što bi ipak moglo biti prvi korak u jednom opsežnom istraživanju. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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