دورية أكاديمية
Oxidative damage to pre-eclamptic placenta: Immunohistochemical expression of VEGF, nitrotyrosine residues and von Willebrand factor
| العنوان: | Oxidative damage to pre-eclamptic placenta: Immunohistochemical expression of VEGF, nitrotyrosine residues and von Willebrand factor |
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| المؤلفون: | Rodrigo Salinas, Ramón, Bosco Becerra, Cleofina, González, Jaime, Gutiérrez, Rodrigo, Parra Cordero, Mauro, Barja Yáñez, Pilar |
| المصدر: | Journal of Maternal-Fetal and Neonatal Medicine |
| سنة النشر: | 2012 |
| المجموعة: | Universidad de Chile: Repositorio académico |
| مصطلحات موضوعية: | Oxidative stress, Peroxynitrite, Placenta, Pre-eclampsia, VEGF, Von Willebrand factor |
| الوصف: | Objective: To determine the relationship of biomarkers of placental damage by oxidative stress in pre-eclamptic placenta. Methods: A case-control study was performed on a population of 14 pregnant women with PE and 12 women with normal pregnancies. Immunohistochemical expressions of VEGF, vWF distribution, (Na + K)-ATPase activity, and abundance of nitrotyrosine residues, were assessed in the placental tissue. Results: Women with pre-eclampsia showed increased VEGF expression and abundance of nitrotyrosine residues in placental villous, and plasma vWF levels (p < 0.05), whereas placental (Na + K)-ATPase activity were significantly reduced. The syncytiotrophoblast and the maternal space of pre-eclamptic placenta showed diminished and increased vWF expression, respectively, but no significant differences in its expression were found in the placental endothelium and stroma (p < 0.05). Conclusions: It could be suggested that increased oxidative stress and VEGF contribute to enhance the imp |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 14767058 14764954 |
| العلاقة: | Journal of Maternal-Fetal and Neonatal Medicine, Volumen 25, Issue 11, 2018, Pages 2339-2345; https://repositorio.uchile.cl/handle/2250/165817Test |
| DOI: | 10.3109/14767058.2012.695823 |
| الإتاحة: | https://doi.org/10.3109/14767058.2012.695823Test https://repositorio.uchile.cl/handle/2250/165817Test |
| حقوق: | Attribution-NonCommercial-NoDerivs 3.0 Chile ; http://creativecommons.org/licenses/by-nc-nd/3.0/clTest/ |
| رقم الانضمام: | edsbas.97B0128 |
| قاعدة البيانات: | BASE |
| تدمد: | 14767058 14764954 |
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| DOI: | 10.3109/14767058.2012.695823 |