المؤلفون: Sklar, Julie, Pyle, Laura, Snell-Bergeon, Janet K., Garcetti, Rachel, Joshee, Prakriti, Demmitt, Jamie K., Polsky, Sarit

المصدر: Journal of Maternal-Fetal & Neonatal Medicine; Dec2022, Vol. 35 Issue 25, p8968-8974, 7p

مصطلحات موضوعية: GLYCEMIC control, TYPE 1 diabetes, GLYCEMIC index, PREGNANT women, GLUCOSE, INSULIN pumps, FETAL monitoring

مستخلص: Background Pregnancies complicated by type 1 diabetes (T1D) experience high levels of glycemic variability, which may be associated with adverse maternal and neonatal outcomes. Therefore, strategies that help pregnant women with T1D manage their glycemic control are of great interest. Methods We examined associations with or without remote monitoring of Continuous Glucose Monitor (CGM) data by friends and family with indices of glycemic control and glycemic variability during pregnancies complicated by T1D in a pilot non-randomized trial (n = 28). During preconception or the first trimester, participants were placed in one of two groups based on device compatibility: (1) CGM Alone (n = 13): women without iPhone, iPad or iPod Touch; or (2) CGM Share (n = 15): women with iPhone, iPad, or iPod Touch and followers with devices compatible for data viewing. Linear mixed models were used to compare indices of glycemic control and glycemic variability over time between groups. Results Participants using CGM Share had lower estimated HbA1c levels over time (p = .028), glucose management index (p = .041), and fewer glucose excursions >200 mg/dL in each trimester (p = .022) compared to those using CGM Alone. Participants using CGM Alone had higher high blood glucose index (p = .020), mean area under the curve (p = .026), and standard deviation (p = .046) compared to those using CGM Share. Other measures of glycemic variability did not differ between groups. Conclusion In this non-randomized pilot study, use of CGM Share was associated with improvements in several indices of glycemic control and glycemic variability. [ABSTRACT FROM AUTHOR]

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المؤلفون: Polsky, Sarit¹ (AUTHOR), Foster, Nicole C.² (AUTHOR), DuBose, Stephanie N.² (AUTHOR), Agarwal, Shivani³ (AUTHOR), Lyons, Sarah⁴ (AUTHOR), Peters, Anne L.⁵ (AUTHOR), Uwaifo, Gabriel I.⁶ (AUTHOR), DiMeglio, Linda A.⁷ (AUTHOR), Sherr, Jennifer L.⁸ (AUTHOR), Levy, Carol J.⁹ (AUTHOR)

المصدر: Journal of Maternal-Fetal & Neonatal Medicine. Dec2022, Vol. 35 Issue 24, p4629-4634. 6p.

مصطلحات موضوعية: *TYPE 1 diabetes, *DIABETES complications, *CARDIOVASCULAR diseases, *BODY mass index, *PREGNANT women

مستخلص: To assess risk factors and incidence of diabetes complications in women with type 1 diabetes (T1D) based on parity. Data were collected from women (16–40 years old) in the T1D Exchange completing pregnancy/childbirth questionnaires during 2011–2013 and 2016–2018. Incidence of risk factors and diabetes complications were compared between women with a first pregnancy at/within 1-year of enrollment (n = 28) and never pregnant women by year 5 (n = 469). There was a trend for lower HbA1c (adjusted p =.14) and higher rates of overweight/obesity, triglyceride/HDL > 2, log (triglyercide/HDL), and hypertension among parous women compared with nulliparous women. There were no significant differences in rates of advanced nephropathy, albuminuria or cardiovascular disease. Four-5 years after delivery, parous women with T1D tended to have lower HbA1c levels despite higher body mass indices and more frequent adverse lipid profiles and hypertension compared with nulliparous women. Further studies based on these trends are warranted. [ABSTRACT FROM AUTHOR]