المؤلفون: Blavier, Frédéric^1,2 fredericblavier@yahoo.fr, Barbe, Kurt³, Faron, Gilles¹, Doutreloup, Sébastien⁴, Boukerrou, Malik^5,6,7, Fuchs, Florent⁸, Gucciardo, Leonardo¹

المصدر: Journal of Maternal-Fetal & Neonatal Medicine. Dec2022, Vol. 35 Issue 25, p6663-6669. 7p.

مصطلحات موضوعية: *CHILDBIRTH, *PREMATURE labor, *ATMOSPHERIC temperature, *ATMOSPHERIC pressure, *TEMPERATURE effect

مصطلحات جغرافية: REUNION, BRUSSELS (Belgium), BELGIUM

مستخلص: Objective We studied potential effects of outdoor air temperatures or barometric pressure on births, preterm births and births associated with maternal hypertension. Methods 12,269 births were retrospectively reviewed in Brussel and 25,880 in South Reunion Island. National Belgium and French weather reference centers provided outdoor air temperatures and barometric pressures from the nearest weather stations on the corresponding birthdays. Poisson regression models were used to assess if outdoor air temperatures or barometric pressure could be correlated, immediately and several days later, with the number of daily births, preterm births and births associated with hypertension. Results Outdoor air temperature was significantly correlated to the number of daily births in Brussels. For each additional degree Celsius, overall births increased by 0.4% during the same day. Four days later, overall births increased by 1.8%, preterm births by 2.6% and births associated with hypertension by 5.7%. Similar observations on numbers of daily births were reported in South Reunion Island, without reaching statistical significance (p = .08). Conclusion As previously demonstrated in recent studies, increased air temperature leads progressively to higher rates of births and preterm births. An even stronger delayed effect of air temperature was observed on births associated with hypertension. This would be worth further investigating. [ABSTRACT FROM AUTHOR]

المؤلفون: Artymuk, Natalia V., Belokrinitskaya, Tatiana E., Filippov, Oleg S., Frolova, Nataly I., Surina, Maria N.

المصدر: Journal of Maternal-Fetal & Neonatal Medicine; Dec2022, Vol. 35 Issue 25, p5427-5430, 4p

مصطلحات موضوعية: PREGNANT women, COVID-19 pandemic, COVID-19, PERINATAL death, PREMATURE labor

مصطلحات جغرافية: SIBERIA (Russia), EAST Asia

مستخلص: Objective: To assess the incidence and perinatal outcomes of COVID-19 in pregnant women in the Far Eastern and Siberian Federal Districts of Russian Federation over 10 months of a pandemic. Materials and methods: This was secondary analysis of Public Data basis on 25 Dec 2020. Statistics included descriptive statistics, analysis of contingency tables, which assessed the value of x², the achieved significance level (p). Results: During the first year of the SARS-CoV-2 pandemic, 8485 cases of COVID-19 were registered in pregnant women in the Far Eastern Federal District and the Siberian Federal District, accounting for 5.9% of registered pregnant women and 1.71% of the total affected population. The morbidity rate in pregnant women was 3.02 times higher than in the general population: 5933.2 vs 1960.8 per 100 thousand population. 27.4% of mothers had asymptomatic disease; 52.7% – mild; 16.6% – moderate, 2.5% – severe, 0.5% – critical disease. The incidence of hospitalization in ICU of pregnant women was higher relative to the general population (3.57% vs 2.24%, p < .001), but the frequency of mechanical ventilation was lower (0.48% vs 1.05%, p < .001). Preterm delivery had 18.3% (p < .001 CS - 42.0%. The mortality rate in pregnant women was 0.14% vs 1.95% – in the general population (p < .001). Perinatal mortality was 37 cases (1.56%), of which there were 31 stillbirths (1.26%), and 6 (0.25%) cases of early neonatal mortality. 148 (6.2%) COVID-19(þ) newborns were identified, despite anti-epidemic measures. Conclusion: The incidence of COVID-19 in pregnant women in Siberia and the Far East is higher than in the general population, but the disease is characterized by a milder. Women with COVID-19 have a high rate of preterm birth and CS. 148 (6.2%) newborns isolated COVID-19. [ABSTRACT FROM AUTHOR]

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المؤلفون: Leneuve-Dorilas, Malika¹ (AUTHOR) malika.leneuve@hotmail.fr, Buekens, Pierre² (AUTHOR), Favre, Anne¹ (AUTHOR), Carles, Gabriel³ (AUTHOR), Louis, Alphonse¹ (AUTHOR), Breart, Gerard⁴ (AUTHOR), Nacher, Mathieu¹ (AUTHOR)

المصدر: Journal of Maternal-Fetal & Neonatal Medicine. May2020, Vol. 33 Issue 10, p1709-1716. 8p.

مصطلحات موضوعية: *FIRST trimester of pregnancy, *PREMATURE labor, *CHILDBIRTH, *DEFINITIONS, *PREGNANCY, *PREMATURE infants, *RETROSPECTIVE studies, *ACQUISITION of data, *RECEIVER operating characteristic curves

مصطلحات جغرافية: FRENCH Guiana

مستخلص: Objective: Given the high rate of premature birth in French Guiana (13.5%), and its stability in time, the aim of the present study was to define a predictive score for preterm birth in women with a unique pregnancy in order to help prioritize health resources in the local context.Methods: A retrospective study was conducted on all deliveries of unique pregnancies in French Guiana collected between 1 January 2013 and 31 December 2014 in the Registre d'Issue de Grossesse Informatisé (RIGI), a registry that collects data on live births over 22 weeks of amenorrhea on the territory. Statistically significant predictors (p < .05) of preterm delivery were included in a logistic regression model. The selected variables were chosen to be available during the first trimester. Coefficients were used to establish a score which was categorized and prospectively validated using data from 2015.Results: Seven explanatory variables, all measurable during the first trimester of pregnancy, were significantly associated with preterm birth. The predictive score divided in deciles allowed to establish sensitivity and specificity thresholds. Overall, depending on the chosen threshold the score sensitivity was low and the specificity was high. Lowering the threshold identified half of women as "at risk" for preterm birth.Conclusion: This first trimester score was insufficiently sensitive to identify individual women at risk for preterm delivery. [ABSTRACT FROM AUTHOR]

المؤلفون: Wang, H.^1,2 (AUTHOR), Yue, H.¹ (AUTHOR) yuehongni@hotmail.com, Sun, B.³ (AUTHOR) bsun@shmu.edu.cn, Zhu, X.¹ (AUTHOR), Niu, H.¹ (AUTHOR), Qi, T.¹ (AUTHOR), Ding, W.¹ (AUTHOR), Han, L.¹ (AUTHOR), Zhang, M.⁴ (AUTHOR), Tian, Z.⁴ (AUTHOR), Guan, H.⁵ (AUTHOR), Yang, J.⁵ (AUTHOR), Li, S.⁶ (AUTHOR), Zhu, K.⁶ (AUTHOR), Tang, C.⁷ (AUTHOR), Dong, M.⁷ (AUTHOR), Yin, Y.² (AUTHOR), Cao, X.⁸ (AUTHOR), Zhang, J.⁸ (AUTHOR), Liu, H.⁹ (AUTHOR)

المصدر: Journal of Maternal-Fetal & Neonatal Medicine. Mar2020, Vol. 33 Issue 5, p838-846. 9p.

مصطلحات موضوعية: *NEONATAL mortality, *PREMATURE labor, *BIRTH rate, *DEMOGRAPHIC surveys, *CHILDBIRTH, *MULTIPLE birth, *PREMATURE infants, *INFANT mortality

مصطلحات جغرافية: JIANGSU Sheng (China), CHINA

مستخلص: Objective: This survey followed the birth population-based study conducted in 2010 in Huai'an, Jiangsu Province, with the aim to estimate perinatal-neonatal mortality and preterm birth rate in emerging regions with similar maternal-fetal and neonatal care conditions in China.Materials and methods: Data of total births in 2015 were prospectively collected by regional perinatal network collaboration in Huai'an, a subprovincial region with a population of 5,644,500 and gross domestic production of 9082 USD per capita.Results: The 59,424 birth registries (including 59,023 live births and 167 stillbirths) corresponded to a birth rate of 10.5‰ and a Male-to-female ratio of 113.7:100. All births there were from 85, 16, and 6 level I, II, and III hospitals, with a delivery rate of 30.4, 40.2, and 29.4%, respectively. Of all births, 14.1% had pregnancy-associated comorbidities and complications, 54.4% (32,226/59,190) had cesarean delivery, and multiple pregnancies and birth defects occurred in 2.1% (1,250) and 5.5‰ (324), respectively. The mean birth weight was 3448 ± 507 g with 13.9% being macrosomia, and 2.86% (1695/59,190) low birth weight. Preterm birth rate was 4.06% (2404/59,190) with a mortality rate of 8.5%. There were 94.5% recorded as healthy newborns and 5.5% (3263) requiring hospitalization after birth. The perinatal and neonatal mortality rate was 5.2‰ (167 stillbirths, 139 early neonatal deaths) and 4.0‰, respectively. Compared with the 2010 survey, these data demonstrated generally improved status of perinatal-neonatal healthcare.Conclusions: The low rates of perinatal-neonatal mortality, preterm birth and preterm mortality suggest that the concept and study protocol of perinatal-neonatal healthcare in Huai'an may serve as the benchmark for estimating regional vital statistics and perinatal and neonatal outcomes. [ABSTRACT FROM AUTHOR]

المؤلفون: Ronzoni, Stefania¹ (AUTHOR) stefania.ronzoni@sunnybrook.ca, D'Souza, Rohan² (AUTHOR), Shynlova, Oksana³ (AUTHOR), Lye, Stephen³ (AUTHOR), Murphy, Kellie E.² (AUTHOR)

المصدر: Journal of Maternal-Fetal & Neonatal Medicine. Oct2019, Vol. 32 Issue 20, p3473-3479. 7p.

مصطلحات موضوعية: *PREMATURE labor, *PREGNANCY, *PREMATURE rupture of fetal membranes, *GESTATIONAL age, *CHILDBIRTH

مستخلص: Objective: To compare maternal blood endotoxin activity (EA) in women with preterm premature rupture of membranes (PPROM) with gestational age (GA) matched controls; to evaluate serial EA till birth in PPROM and its correlation with latency to delivery. Methods: We followed singleton preterm pregnancies from admission with PPROM until birth. Uncomplicated, GA-matched pregnancies served as controls. Demographics, birth and neonatal outcomes were collected. EA (EAA™) was assessed serially in PPROM and at study entry in controls. EA was compared using Mann Whitney and Wilcoxon tests, p value <.05 was considered significant. Results: We recruited 20 cases of PPROM and 20 controls. Demographics were similar between groups. Mean GA of PPROM was 29.0 ± 2.2 weeks and median latency was 7.5 (IQR 14.1) weeks. Median EA at admission following PPROM was significantly elevated over controls (0.43 (0.18) versus 0.36 (0.2); p <.02). Overall there was no difference in median EA at admission and in labor (0.43 (0.18) versus 0.33 (0.21); p =.2) following PPROM. However, on comparing cases with latency to delivery ≤7 days (n = 10) versus >7 days (n = 10), there was a significant drop in EA in the latter group (0.44 (0.2) versus 0.34 (0.2); p <.004). Conclusions: EA in PPROM represents a promising biomarker in predicting the clinical evolution of preterm birth. [ABSTRACT FROM AUTHOR]

المؤلفون: Leneuve-Dorilas, Malika¹ malika.leneuve@hotmail.fr, Favre, Anne¹, Carles, Gabriel², Louis, Alphonse¹, Nacher, Mathieu¹

المصدر: Journal of Maternal-Fetal & Neonatal Medicine. Apr2019, Vol. 32 Issue 8, p1388-1396. 9p.

مصطلحات موضوعية: *PREMATURE labor, *DISEASE risk factors, *CHILDBIRTH, *BIRTH rate, *HEALTH

مصطلحات جغرافية: FRENCH Guiana, SOUTH America

مستخلص: Objectives: French Guiana has the highest birth rate in South America. This French territory also has the highest premature birth rate and perinatal mortality rate of all French territories. The objective was to determine the premature birth rate and to identify the prevalence of risk factors of premature birth in French Guiana.Methods: A retrospective study of all births in French Guiana was conducted between January 2013 and December 2014 using the computerized registry compiling all live births over 22 weeks of gestation on the territory.Results: During this period 12 983 live births were reported on the territory. 13.5% of newborns were born before 37 (1755/12 983). The study of the registry revealed that common sociodemographic risk factors of prematurity were present. In addition, past obstetrical history was also important: a scarred uterus increased the risk of prematurity adjusted odds ratio =1.4, 95%CI (1.2-1.6). Similarly, obstetrical surveillance, the absence of preparation for birth or of prenatal interview increased the risk of prematurity by 2.4 and 2.3, the excess fraction in the population was 69% and 72.2%, respectively.Conclusions: Known classical risk factors are important. In the present study excess fractions were calculated in order to prioritize interventions to reduce the prematurity rate. [ABSTRACT FROM AUTHOR]

المؤلفون: Levin, Heather I.^1,2 heather.levin@gmail.com, Sciscione, Anthony³, Ananth, Cande V.^1,4, Drassinower, Daphnie^1,5, Obican, Sarah G.^1,6, Wapner, Ronald J.¹

المصدر: Journal of Maternal-Fetal & Neonatal Medicine. Aug2018, Vol. 31 Issue 16, p2136-2140. 5p.

مصطلحات موضوعية: *PREMATURE labor, *PREGNANCY complications, *LABOR complications (Obstetrics), *PREMATURE infants, *CHILDBIRTH, *BED rest, *GESTATIONAL age, *LONGITUDINAL method, *ACTIVITIES of daily living

مستخلص: Purpose: We sought to determine whether activity restriction (AR) in a cohort of women at high risk for preterm delivery is associated with the risk of preterm delivery.Materials and Methods: This is a secondary analysis of the Maternal-Fetal Medicine Units MFMU's Preterm Prediction Study; a multicenter prospective cohort study designed to identify risk factors of preterm birth (PTB). The study group consisted of women with a singleton gestation that at their first study visit (23-24 weeks) had at least one of the following criteria: patient reported contractions, severe back pain, a cervical length <15 mm, spotting, protruding membranes, or positive fetal fibronectin. Women were assessed for AR at a 27- to 29-week study visit. Associations between AR and preterm delivery (<37 weeks) were examined through logistic regression models before and after adjustment for confounders.Results: Of the 1086 women that met the inclusion criteria, 16.5% (n = 179) delivered preterm. In this cohort, 9.7% (n = 105) of women were recommended AR, with 37.1% (n = 39) having a PTB. In the group not recommended AR (n = 981), 14.3% (n = 140) delivered preterm.Conclusion: In this cohort of women at high risk for PTB, activity restriction was associated with an increased risk of PTB. The use of AR in this population should be discouraged. [ABSTRACT FROM AUTHOR]

المؤلفون: Mosbah, Alaa¹ (AUTHOR) alaamosbah@hotmail.com, Barakat, Rafik¹ (AUTHOR), Nabiel, Yasmin² (AUTHOR), Barakat, Ghada² (AUTHOR)

المصدر: Journal of Maternal-Fetal & Neonatal Medicine. Mar2018, Vol. 31 Issue 6, p720-725. 6p.

مصطلحات موضوعية: *PAPILLOMAVIRUSES, *PREMATURE labor, *OBSTETRICS, *MEDICINE, *CHILDBIRTH, *PREMATURE labor prevention, *PAPILLOMAVIRUS disease diagnosis, *GENE expression, *GESTATIONAL age, *PAPILLOMAVIRUS diseases, *POLYMERASE chain reaction, *PROTEOLYTIC enzymes, *SPECIALTY hospitals, *CASE-control method

مصطلحات جغرافية: EGYPT

مستخلص: Introduction: This study aimed to detect the correlation between human papillomavirus (HPV) and spontaneous preterm labor in Egyptian women and its association to the human papilloma viral load and MPP2 gene expression.Material and Methods: We performed an observational comparative case-control study in Department of Obstetric and Gynecology, Mansoura University Hospitals over women presented with spontaneous preterm labor, besides females admitted for giving birth at full term to detect conserved sequence in HPV-L1 gene (GP5/GP6) followed by genotype detection of high- and low-risk HPVs with quantification of the viral load and the MMP2 gene expression using real-time polymerase chain reaction (PCR).Results: The prevalence of HPV was 18.1% in preterm females, but only 4% in full-term women (p value = 0.019*). Twenty percent were PCR positive for HPV 16 and 40% for HPV 18 whereas none of the control was positive for any of the studied high-risk genotypes. Thirty percent were PCR positive for HPV 6 and 10% were positive for HPV 11. MMP2 gene expression was significantly higher in preterm than full term. Human papilloma viral load was found to be positively correlated to the rate of MMP2 expression and the gestational age was significantly related to the viral load and the rate of expression of MMP2 gene.Conclusion: Human pabilloma virus especially high-risk genotypes was correlated to spontaneous preterm labor in Egyptian females through increasing early expression of MMP2 gene. The time of occurrence of preterm labor was affected by the viral load and so the rate of expression of MMP2 gene. [ABSTRACT FROM AUTHOR]

المؤلفون: Berezowsky, Alexandra¹ (AUTHOR), Mazkereth, Ram² (AUTHOR), Ashwal, Eran¹ (AUTHOR), Mazaki-Tovi, Shali¹ (AUTHOR), Schiff, Eyal¹ (AUTHOR), Weisz, Boaz¹ (AUTHOR), Lipitz, Shlomo¹ (AUTHOR), Yinon, Yoav¹ (AUTHOR) yoav.yinon27@gmail.com

المصدر: Journal of Maternal-Fetal & Neonatal Medicine. Apr2016, Vol. 29 Issue 8, p1252-1256. 5p.

مصطلحات موضوعية: *TWINS, *RISK factors in premature labor, *DELIVERY (Obstetrics), *CHILDBIRTH, *DURATION of pregnancy, *GESTATIONAL age, *HOSPITAL admission & discharge, *HYPOTHERMIA, *PREMATURE infants, *NEONATAL jaundice, *LONGITUDINAL method, *MULTIPLE pregnancy, *NEONATAL intensive care, *OXYGEN therapy, *PATIENTS, *PHOTOTHERAPY, *RESPIRATORY distress syndrome, *NEONATAL intensive care units, *RETROSPECTIVE studies

مصطلحات جغرافية: ISRAEL

مستخلص: Objective: To determine the neonatal outcome at late prematurity of uncomplicated monochorionic (MC) twin pregnancies.Methods: A retrospective cohort study of 166 patients with uncomplicated MC diamniotic twins delivered between 34 and 37 weeks of gestation at a single tertiary center. The study population was classified into four groups according to the gestational age at delivery: (1) 34 weeks, (2) 35 weeks, (3) 36 weeks and (4) 37 weeks. Neonatal outcome measures were compared between the groups.Results: Neonatal morbidity was significantly higher at 34 weeks of gestation compared to the other three groups including respiratory distress syndrome, oxygen requirement, hypothermia and hyperbilirubinemia. Moreover, the rate of admission to the special care unit and need for phototherapy were significantly higher in newborns born at 36 weeks compared to 37 weeks of gestation (p = 0.02 and 0.03 respectively). Multiple regression analysis revealed that the risk for adverse neonatal outcome was significantly associated with gestational age at delivery. Of note, there were no fetal or neonatal deaths in our cohort.Conclusions: The risk of neonatal morbidity of uncomplicated MC twins delivered at 34-37 weeks of gestation significantly decreases with advanced gestation. Therefore, under close fetal surveillance, uncomplicated MC twin pregnancies should be delivered at 37 weeks of gestation. [ABSTRACT FROM AUTHOR]

المؤلفون: Masturzo, Bianca¹ (AUTHOR) bmasturzo@cittadellasalute.to.it, De Ruvo, Daniele¹ (AUTHOR), Gaglioti, Pietro¹ (AUTHOR), Todros, Tullia¹ (AUTHOR)

المصدر: Journal of Maternal-Fetal & Neonatal Medicine. Oct2014, Vol. 27 Issue 15, p1560-1563. 4p.

مصطلحات موضوعية: *PREMATURE labor, *CHILDBIRTH, *ULTRASONIC imaging, *OXYTOCIN, *FETAL heart rate monitoring

مستخلص: Objective: To reduce the operative delivery rate in the prolonged second stage of labor (PSSL) through intrapartum sonography. Methods: Sixty-two women - with uncomplicated pregnancies at term, fetus in cephalic presentation and occipitoanterior position, in PSSL - had already undergone epidural anesthesia and oxytocin infusion. Transperineal ultrasound was performed to define fetal head direction (downward, horizontal, and upward) and patients were divided into three groups (D, H, and U). Proposed protocol: Cessation of oxytocin infusion, addition of a dose of anesthesia, invitation to assume a hand-and-knee position, and to relax. After one hour, oxytocin infusion was started again and women were invited to push. Fetal well-being ensured by cardiotocography (CTG). Chi-square test was used to compare the mode of delivery: cesarean section (CS), vacuum extraction (VE), and spontaneous delivery (SD). Results: Group D ( n = 20): 4 SD (20%), 4 VE, 12 CS; group H ( n = 22): 9 SD (41%), 9 VE, 4 CS; group U ( n20): 16 SD (80%), 4 VE. The risk of not having a SD in group D versus U is quadrupled (RR 4; 95% CI 1.6-9.9). Conclusions: Ultrasound diagnosis of fetal head upward direction is highly predictive of SD in case of PSSL. Further studies are needed to assess this hypothesis. [ABSTRACT FROM AUTHOR]