Triple therapy of hepatocellular carcinoma with microRNA-122 and doxorubicin co-loaded functionalized gold nanocages
| العنوان: | Triple therapy of hepatocellular carcinoma with microRNA-122 and doxorubicin co-loaded functionalized gold nanocages |
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| المؤلفون: | Mengfei Ji, Ying Liu, Yuanmin Li, Shengnan Huang, Xin Xu, Shaofeng Duan, Yurong Hu, Chengjun Song |
| المصدر: | Journal of Materials Chemistry B. 6:2217-2229 |
| بيانات النشر: | Royal Society of Chemistry (RSC), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Biodistribution, Chemistry, Genetic enhancement, Biomedical Engineering, General Chemistry, General Medicine, Photothermal therapy, 03 medical and health sciences, 030104 developmental biology, Nanocages, Targeted drug delivery, In vivo, Drug delivery, medicine, Cancer research, General Materials Science, Doxorubicin, medicine.drug |
| الوصف: | A combination of different therapy strategies has great potential to efficaciously treat malignant tumors, by virtue of their synergetic effects. Herein, a co-delivery system based on gold nanocages (AuNCs) was designed to deliver both doxorubicin (DOX) and microRNA-122 mimic (miR-122) for an enhanced cancer therapy. DOX was loaded into the AuNCs and miR-122 was condensed onto the surface of the functionalized AuNCs by an electrostatic interaction. Polyethyleneglycol (PEG) and hyaluronic acid (HA) were also introduced to the co-delivery system for targeted drug delivery. We evaluated the cellular uptake, biodistribution and anti-tumor effect in vitro and in vivo. Our results demonstrated an effective delivery of DOX and miR-122 into tumor cells and the tumor tissue. Importantly, the triple therapy, namely the combination of chemotherapy, gene therapy and photothermal therapy, mediated by this multifunctional drug delivery system, exhibited better anti-tumor effect than any single therapy, both in vitro and in vivo. Additionally, this drug delivery system caused insignificant toxicity to the major organs and had no obvious effect on the body weight of the mice. It could be concluded that multifunctional AuNCs are promising as a co-delivery vector for an enhanced anti-tumor effect. |
| تدمد: | 2050-7518 2050-750X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::544cb7ae3a3d716fe86e0efa06e6dceaTest https://doi.org/10.1039/c8tb00224jTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....544cb7ae3a3d716fe86e0efa06e6dcea |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20507518 2050750X |
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