المؤلفون: Vera Bittner, Sotirios Tsimikas, Robert S. Rosenson, Paul Muntner, Mary Cushman, Keri L. Monda, Todd M. Brown, Matthew T. Mefford, Santica M. Marcovina, J. Antonio G. López, Michael E. Farkouh

المصدر: Journal of Lipid Research, Vol 60, Iss 11, Pp 1946-1952 (2019)
Journal of lipid research, vol 60, iss 11
J Lipid Res

مصطلحات موضوعية: 0301 basic medicine, Male, medicine.medical_specialty, Biochemistry & Molecular Biology, Apolipoprotein B, apolipoprotein, Renal function, QD415-436, 030204 cardiovascular system & hematology, Medical Biochemistry and Metabolomics, Cardiovascular, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Loss of Function Mutation, Clinical Research, Internal medicine, medicine, Humans, proprotein convertase subtilisin-kexin type 9, African Americans, biology, business.industry, Oxidized phospholipid, PCSK9, lipoprotein, lipoprotein (a), Cell Biology, Lipoprotein(a), Statin treatment, Middle Aged, Phenotype, United States, Black or African American, 030104 developmental biology, biology.protein, Female, oxidized phospholipids, epidemiology, Biochemistry and Cell Biology, Proprotein Convertase 9, business, Patient-Oriented and Epidemiological Research, Lipoprotein

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c217d833f3b7ea5f98870731b614d60Test
http://www.sciencedirect.com/science/article/pii/S0022227520322926Test

المؤلفون: Kirill Zhudenkov, Bengt Hamrén, Rasmus Jansson-Löfmark, Eva Hurt-Camejo, Catarina Nilsson, Gabriel Helmlinger, Stanko Skrtic, Kirill Peskov, Victor Sokolov

المصدر: Journal of Lipid Research, Vol 60, Iss 9, Pp 1610-1621 (2019)
Journal of Lipid Research

مصطلحات موضوعية: 0301 basic medicine, Small interfering RNA, Apolipoprotein B, Cholesterol, VLDL, Hypercholesterolemia, QD415-436, 030204 cardiovascular system & hematology, Pharmacology, Antibodies, Monoclonal, Humanized, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Humans, Medicine, RNA, Small Interfering, Triglycerides, Apolipoproteins B, plasma proprotein convertase subtilisin/kexin type 9, biology, business.industry, PCSK9, Cholesterol, HDL, Antibodies, Monoclonal, Cholesterol, LDL, Cell Biology, Lipoprotein(a), Models, Theoretical, Proprotein convertase, lipoproteins, quantitative modeling, 030104 developmental biology, Drug development, cholesterol metabolism, biology.protein, Kexin, lipids (amino acids, peptides, and proteins), Proprotein Convertase 9, atherosclerosis, translational pharmacology, Patient-Oriented and Epidemiological Research, business, Systems pharmacology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db5cee2fd06a636b7abc4f01e227b7dcTest
https://doi.org/10.1194/jlr.m092486Test

المؤلفون: Nabil G. Seidah

المصدر: Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100130-(2021)

مصطلحات موضوعية: CHRD, Cys-His-rich domain, Apolipoprotein B, HEK293, human embryonic kidney 293, DENV, dengue virus, Familial hypercholesterolemia, 030204 cardiovascular system & hematology, S1P, site 1 protease, Biochemistry, 0302 clinical medicine, Endocrinology, Thematic Review Series: The Science of FH, Neoplasms, lipid metabolism, GOF, gain-of-function, cancer/metastasis, Receptor, 0303 health sciences, biology, LDLR, LDL receptor, SKI-1, subtilisin-kexin isozyme 1, 3. Good health, Virus Diseases, lipids (amino acids, peptides, and proteins), Proprotein Convertase 9, furin, Endosome, Hypercholesterolemia, QD415-436, FH, familial hypercholesterolemia, ER, endoplasmic reticulum, 03 medical and health sciences, cDNA, complementary DNA, lysosomes, Zymogen, medicine, MHC, major histocompatibility complex, Animals, Humans, mAb, monoclonal antibody, LDL-C, 030304 developmental biology, PCSK9, proprotein convertases, Thematic Review Series, PC, proprotein convertase, Cell Biology, Proprotein convertase, medicine.disease, LDLR, inflammation, LDL receptor, Cancer research, biology.protein, viral infection, PCSK9, proprotein convertase subtilisin/kexin type 9, LOF, loss of function, NARC-1, neural apoptosis-regulated convertase 1

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa9b1dcccbf273c1836a23142dd023f3Test
http://europepmc.org/articles/PMC8551645Test

المؤلفون: Yishi Shen, Shucun Qin, Bingxiang Wang, Yongfang Zhao, Lei Zhai, Boyan Liu, Xiaole Chang, Adekunle Alabi, Shijun Deng, Maggie Wang, Hong-mei Gu, Da-Wei Zhang, Xiao-dan Xia, Guiqing Wang, Sijie Xing

المصدر: Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100091-(2021)

مصطلحات موضوعية: 0301 basic medicine, Alb, albumin, Very low-density lipoprotein, Apolipoprotein B, TANGO1, Transport and Golgi Organization 1, 030204 cardiovascular system & hematology, Lipoproteins, VLDL, Biochemistry, Microsomal triglyceride transfer protein, apoB100, chemistry.chemical_compound, Mice, 0302 clinical medicine, Endocrinology, AAV, adeno-associated virus, stearyl-CoA-1, lipid metabolism, COPII, classical coat protein complex II, Cells, Cultured, lipoprotein metabolism, Mice, Knockout, apoB, apolipoprotein B, biology, CE, cholesteryl ester, TG, triglyceride, LDLR, LDL receptor, Surf4, Surfeit 4, MTP, microsomal triglyceride transfer protein, Lipogenesis, Cholesteryl ester, lipids (amino acids, peptides, and proteins), ASCVD, atherosclerotic cardiovascular disease, Proprotein Convertase 9, Research Article, medicine.medical_specialty, apoB100, apolipoprotein B100, QD415-436, liver, LDL, 03 medical and health sciences, Internal medicine, ALT, alanine aminotransferase, medicine, Animals, Secretion, triglyceride, Cholesterol, Surf4LKO, Surf4 liver-specific knockout, nutritional and metabolic diseases, Membrane Proteins, SCD1, stearoyl-CoA desaturase-1, Cell Biology, Atherosclerosis, TC, total cholesterol, Mice, Inbred C57BL, 030104 developmental biology, LDLR, chemistry, Receptors, LDL, LDL receptor, biology.protein, VTV, VLDL transport vesicle, apolipoproteins, PCSK9, proprotein convertase subtilisin/kexin type 9

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ace96902105c8bd0f6e5ca427b95574Test
http://europepmc.org/articles/PMC8261665Test

المؤلفون: Nathalie Pamir, Joshua Hay, Carlota Oleaga, Emma Gurcan, Sergio Fazio, Larry L. David, Hagai Tavori, Paul Mueller, Michael D. Shapiro

المصدر: Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100003-(2021)

مصطلحات موضوعية: 0301 basic medicine, aa, amino acid, pPCSK9 62∗R46L, expression plasmid for PCSK9_62 R46L, QD415-436, 030204 cardiovascular system & hematology, Biochemistry, PCSK9, ER, endoplasmic reticulum, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, cardiovascular disease, Extracellular, Secretion, pPCSK9 62∗R218S, expression plasmid for PCSK9_62 R218S, PCSK9_55, furin-cleaved form of PCSK9 (55 kDa), Receptor, Furin, PCSK9_62, mature form of PCSK9, pPCSK9 ΔPD, expression plasmid for PCSK9_62 lacking the prodomain, lipoprotein metabolism, biology, Chemistry, pFURIN, expression plasmid for furin, Subtilisin, proprotein convertases, LDL receptor, Cell Biology, Proprotein convertase, pPCSK9 PD, expression plasmid for PCSK9 prodomain, Cell biology, pPCSK9 62, expression plasmid for PCSK9_62, 030104 developmental biology, ProPCSK9, precursor form of PCSK9, PCSK9, Proprotein convertase subtilisin/kexin type 9, LDL cholesterol, pPCSK9 55, expression plasmid for PCSK9_55, biology.protein, Kexin, posttranslational modifications, Proprotein Convertase 9, Intracellular, LDL-C, low density lipoprotein cholesterol, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d8feb98f2ec5d78753afb47e255e58Test
http://europepmc.org/articles/PMC7890205Test

المؤلفون: David G. McLaren, CarolAnn Keohan, Stephanie Williams, Steven R. Bartz, Andy Liaw, Yong Ma, Shirly Pinto, Karen O. Akinsanya, Stephen F. Previs, Yanqing Kan, Marija Tadin-Strapps, Steven J. Stout, Kristian K. Jensen, Ablatt Mahsut, James Hubert, David Coelho, Martin Koser, Gail Forrest, Kithsiri Herath, Satya Yendluri, Shubing Wang, Sheng-Ping Wang

المصدر: Journal of Lipid Research, Vol 57, Iss 12, Pp 2150-2162 (2016)
Journal of Lipid Research

مصطلحات موضوعية: 0301 basic medicine, Male, Small interfering RNA, Simvastatin, small interfering ribonucleic acid, Gene Expression, 030204 cardiovascular system & hematology, Biochemistry, proprotein convertase subtilisin kexin type 9, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, RNA, Small Interfering, Research Articles, Hypolipidemic Agents, Sterol Regulatory Element Binding Proteins, Gene knockdown, cardiometabolic disease, biology, SREBP cleavage-activating protein, Intracellular Signaling Peptides and Proteins, metabolic disease, Lipids, animal models, drug therapy, Liver, Gene Knockdown Techniques, Lipogenesis, lipids/liver, Female, RNA Interference, lipids (amino acids, peptides, and proteins), Proprotein Convertase 9, Signal Transduction, medicine.medical_specialty, lipid and lipoprotein metabolism, QD415-436, 03 medical and health sciences, Internal medicine, medicine, Animals, Humans, RNA, Messenger, Cholesterol, dyslipidemia, Membrane Proteins, cholesterol, Lipid metabolism, Cell Biology, Macaca mulatta, Sterol regulatory element-binding protein, Mice, Inbred C57BL, 030104 developmental biology, chemistry, Receptors, LDL, LDL receptor, biology.protein, low density lipoprotein

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af37a914ad8babe8855bb8f3efecb08fTest
http://www.sciencedirect.com/science/article/pii/S0022227520345417Test

المؤلفون: Pierre Kieffer, Jean-Philippe Girardet, Khaldia Belabbas, Anne Lienhardt, Ahlam Azar-Kolakez, François Labarthe, Anne-Marie Colin Gorsky, Olivier Lascols, Béatrice Dubern, Franck Boccara, Catherine Tamarindi, Mathilde Di Filippo, Jean-Claude Carel, Félicien MBou, Alice Horovitz, René Wintjens, Dominique Bozon, Mathilde Jolly, Fabienne Dufernez, Ariel Cohen, François Feillet, Patrick Tounian, A. Karsenty

المساهمون: Université Libre de Bruxelles [Bruxelles] (ULB), Centre de Biologie et Pathologie Est (CBPE), Hospices Civils de Lyon (HCL)-Centre National de Référence des Légionelles, Laboratoire Commun de Biologie et Génétiques Moléculaires (LCBGM [Hôpital Saint-Antoine]), AP-HP - Hôpital Saint-Antoine, Service d’Endocrinologie [Hôpital le Lamentin Bourg - CHU de la Martinique], CHU de la Martinique [Fort de France]-Hôpital Le Lamentin Bourg [CHU de la Martinique], CHU de la Martinique [Fort de France], Service de Gastroentérologie et Nutrition Pédiatrique [APHP Trousseau], CHU Trousseau [APHP], Service d'Endocrinologie, Diabétologie et Nutrition [CHU Angers], Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Service de Cardiologie [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Saint-Antoine [APHP], Service d'endocrinologie diabétologie pédiatrique [CHU Debré], AP-HP Hôpital universitaire Robert-Debré [Paris], Centre de Référence des Maladies Endocriniennes Rares de la Croissance [APHP Robert Debré], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7), Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Service de Médecine Infantile III et Génétique Clinique [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Nutrition, croissance et cancer (U 1069) (N2C), Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de médecine pédiatrique [CHRU Tours-Clocheville], Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Centre Hospitalier d'Argenteuil, Service de Cardiologie [CHU Bordeaux], CHU Bordeaux [Bordeaux], Service de Maternité [CHU Hagueneau], Centre Hospitalier Hagueneau (CH Hagueneau), Service de Médecine Interne [CH Mulhouse- E. Muller], Centre Hospitalier Emile Muller [Mulhouse] (CH E.Muller Mulhouse), Groupe Hospitalier de Territoire Haute Alsace (GHTHA)-Groupe Hospitalier de Territoire Haute Alsace (GHTHA), Service de Pédiatrie médicale - Spécialités médicales [CHU Limoges], CHU Limoges, Université Pierre et Marie Curie - Paris 6 - UFR de Médecine Pierre et Marie Curie (UPMC), Université Pierre et Marie Curie - Paris 6 (UPMC), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Université libre de Bruxelles (ULB), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Victor Dupouy, Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Biology-Imaging District of East-Hospitals Group of AP-HP (Assistance Publique-Hopitaux de Paris), Université de Lorraine (UL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Tours, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université Paris Diderot - Paris 7 (UPD7)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré, Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA)

المصدر: Journal of Lipid Research
Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 2016, 57 (3), pp.482-491. ⟨10.1194/jlr.P055699⟩
Journal of Lipid Research, 2016, 57 (3), pp.482-491. ⟨10.1194/jlr.P055699⟩
Journal of Lipid Research 3 (57), 482-491. (2016)
Journal of Lipid Research, Vol 57, Iss 3, Pp 482-491 (2016)
Journal of lipid research, 57 (3

مصطلحات موضوعية: Male, Models, Molecular, Protein Conformation, alpha-Helical, 0301 basic medicine, Apolipoprotein E, Genotyping Techniques, Apolipoprotein B, Familial hypercholesterolemia, apolipoprotéine, 030204 cardiovascular system & hematology, medicine.disease_cause, Biochemistry, Cohort Studies, Exon, 0302 clinical medicine, Endocrinology, Child, apolipoprotein E, Genetics, Mutation, familial hypercholesterolemia, biology, cholestérol, Exons, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Endocrinologie, 3. Good health, phénotype, Phenotype, Kexin, Female, lipids (amino acids, peptides, and proteins), France, Proprotein Convertase 9, génotype, corrélation, Adult, Biochimie, hypercholestérolemie, QD415-436, Hyperlipoproteinemia Type II, Young Adult, 03 medical and health sciences, Apolipoproteins E, apolipoproteins, cholesterol, low density lipoprotein, phenotype/genotype correlation, medicine, Humans, Apolipoproteins B, PCSK9, Cell Biology, medicine.disease, 030104 developmental biology, Receptors, LDL, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, LDL receptor, biology.protein, Biologie cellulaire, Patient-Oriented and Epidemiological Research

وصف الملف: application/pdf; 2 full-text file(s): application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1898cff39612d916c240b82c79ea07eTest
https://doi.org/10.1194/jlr.p055699Test

المؤلفون: Patrick Couture, Jean-Philippe Drouin-Chartier, Jean-Charles Hogue, Benoît Lamarche, Valéry Lemelin, André J. Tremblay

المصدر: Journal of Lipid Research, Vol 59, Iss 8, Pp 1501-1509 (2018)

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, medicine.medical_specialty, Apolipoprotein B, medicine.medical_treatment, Lipoproteins, QD415-436, 030204 cardiovascular system & hematology, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Young Adult, proprotein convertase subtilisin/kexin type 9, 0302 clinical medicine, Endocrinology, Insulin resistance, Internal medicine, medicine, Humans, Intestinal Mucosa, Triglycerides, Research Articles, biology, Triglyceride, Chemistry, Cholesterol, PCSK9, Insulin, cholesterol, Cell Biology, Middle Aged, medicine.disease, 030104 developmental biology, Cross-Sectional Studies, Gene Expression Regulation, biology.protein, Kexin, lipids (amino acids, peptides, and proteins), Caco-2 Cells, Insulin Resistance, Proprotein Convertase 9, Apolipoprotein B-48, Chylomicron

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de1a15971c3892feefbd10365a6568f3Test
https://pubmed.ncbi.nlm.nih.gov/29946054Test

المؤلفون: Dieter Lütjohann, Ylva Bonde, Stefan Sjöberg, Olof Breuer, Bo Angelin, Mats Rudling

المصدر: Journal of Lipid Research, Vol 55, Iss 11, Pp 2408-2415 (2014)
Journal of Lipid Research

مصطلحات موضوعية: Blood Glucose, Male, endocrine system diseases, cholesterol/absorption, Hyperthyroidism, Biochemistry, Intestinal absorption, chemistry.chemical_compound, Endocrinology, Insulin, Anilides, Receptors, Thyroid Hormone, biology, Serine Endopeptidases, Thyroid, drug therapy/hypolipidemic drugs, Lipoprotein(a), Middle Aged, Cholesterol, medicine.anatomical_structure, Liver, Body Composition, Female, lipids (amino acids, peptides, and proteins), Proprotein Convertases, Proprotein Convertase 9, hormones, hormone substitutes, and hormone antagonists, Adult, Fibroblast Growth Factor 9, Thyroid Hormones, medicine.medical_specialty, endocrine system, Adolescent, fibroblast growth factor 21, bile acids and salts/biosynthesis, QD415-436, Bile Acids and Salts, Young Adult, proprotein convertase subtilisin/kexin type 9, lipoproteins/metabolism, eprotirome, Internal medicine, fibroblast growth factor, medicine, Humans, Aged, Apolipoproteins B, fibroblast growth factor 19, PCSK9, Cell Biology, cholesterol 7alpha-hydroxylase, Fibroblast Growth Factors, Intestinal Absorption, Eprotirome, chemistry, biology.protein, Patient-Oriented and Epidemiological Research, Lipoprotein, Hormone

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd7e5e10acd36fe0de625db2b14d2b31Test
http://www.sciencedirect.com/science/article/pii/S0022227520349920Test

المؤلفون: Yongcheng Huang, Jonathan C. Cohen, Yan Wang, Helen H. Hobbs

المصدر: Journal of Lipid Research, Vol 53, Iss 9, Pp 1932-1943 (2012)
Journal of Lipid Research

مصطلحات موضوعية: Proteasome Endopeptidase Complex, autophagy, Endosome, Endocytic cycle, QD415-436, 030204 cardiovascular system & hematology, Endocytosis, Clathrin, Biochemistry, ESCRT, Cell Line, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, lysosomes, Humans, Research Articles, 030304 developmental biology, 0303 health sciences, biology, Serine Endopeptidases, nutritional and metabolic diseases, cholesterol, Cell Biology, Fibroblasts, Proprotein convertase, low density lipoprotein receptor, Cell biology, Receptors, LDL, endosomes, Proteolysis, LDL receptor, biology.protein, Kexin, lipids (amino acids, peptides, and proteins), Proprotein Convertases, Proprotein Convertase 9

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c2cdae56a9e1c860dfc9e3ab7d5f168Test
http://www.sciencedirect.com/science/article/pii/S0022227520418358Test