Role of extracellular vesicles in atherosclerosis: An update
| العنوان: | Role of extracellular vesicles in atherosclerosis: An update |
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| المؤلفون: | Chantal M. Boulanger, Pierre-Michael Coly |
| المساهمون: | Boulanger, Chantal, Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité) |
| المصدر: | Journal of Leukocyte Biology Journal of Leukocyte Biology, Society for Leukocyte Biology, 2022, 111 (1), pp.51-62. ⟨10.1002/JLB.3MIR0221-099R⟩ |
| بيانات النشر: | Oxford University Press (OUP), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Inflammation, Senescence, Cell type, Angiogenesis, Immunology, Cell Biology, Biology, Extracellular vesicles, endothelial cells, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Cell biology, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Disease Progression, medicine, Animals, Humans, biomarker, Immunology and Allergy, atherosclerosis, medicine.symptom, extracellular vesicles, Lipid bilayer, Cellular Senescence, Intracellular |
| الوصف: | Extracellular vesicles (EVs) are membrane particles released by most cell types in response to different stimuli. They are composed of a lipid bilayer that encloses a wide range of bioactive material, including proteins and nucleic acids. EVs have garnered increasing attention over recent years, as their role in intercellular communication has been brought to light. As such, they have been found to regulate pathophysiologic pathways like inflammation, angiogenesis, or senescence, and are therefore implicated in key aspects atherosclerosis initiation and progression. Interestingly, EVs appear to have a multifaceted role; depending on their cargo, they can either facilitate or hamper the development of atherosclerotic lesions. In this review, we examine how EVs of varying origins may be implicated in the different phases of atherosclerotic lesion development. We also discuss the need to standardize isolation and analysis procedures to fully fulfil their potential as biomarkers and therapeutics for cardiovascular diseases. |
| وصف الملف: | application/pdf |
| تدمد: | 1938-3673 0741-5400 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::377963f85846d7613c5990becc272544Test https://doi.org/10.1002/jlb.3mir0221-099rTest |
| حقوق: | EMBARGO |
| رقم الانضمام: | edsair.doi.dedup.....377963f85846d7613c5990becc272544 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19383673 07415400 |
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