Azelastine in the Prophylactic Treatment of Bronchial Asthma: An Italian Multicentre Comparison with Ketotifen
| العنوان: | Azelastine in the Prophylactic Treatment of Bronchial Asthma: An Italian Multicentre Comparison with Ketotifen |
|---|---|
| المؤلفون: | E. Catena, A. Mattiello, G. Piacenza, Palermo B, G. Ferretti, M. Robuschi, M. Ciampini, S. Spagnotto, L. Ambrosi, F.G. Marchioni, F. Panzera, Marzo C, Giuseppe Girbino, P. Russo, Antonio Mistretta, S. Valenti, M. Carino, P. Viggiani, Alessandro Sanduzzi, P. Zanon, M. Muratori, M. Condoluci, Nunzio Crimi, R. Maselli, G. Gambaro, G. Pinizzotto, G. Ceccarelli, F. Bariffi |
| المصدر: | Europe PubMed Central |
| بيانات النشر: | SAGE Publications, 1989. |
| سنة النشر: | 1989 |
| مصطلحات موضوعية: | Adult, Ketotifen, medicine.medical_specialty, Allergy, 030204 cardiovascular system & hematology, Placebo, Biochemistry, Azelastine, bronchial asthma, ketotifen, prophylaxis, Asthma, Clinical Trials as Topic, Histamine H1 Antagonists, Humans, Italy, Middle Aged, Multicenter Studies as Topic, Phthalazines, Pyridazines, Cell Biology, Biochemistry (medical), 03 medical and health sciences, 0302 clinical medicine, medicine, Respiratory function, business.industry, Respiratory disease, General Medicine, medicine.disease, Surgery, Regimen, 030220 oncology & carcinogenesis, Anesthesia, business, medicine.drug |
| الوصف: | The prophylactic effectiveness of the phthalazinone derivative, azelastine was compared with ketotifen. A total of 111 patients, aged 18 – 65 years, from 10 centres was entered into this randomized, double-blind study. All patients had reversible asthma. After 1 week on placebo, patients were allocated to either 8 mg/day azelastine once or twice daily, or to 1 mg ketotifen, twice daily, for a further 12 weeks. Azelastine was more effective in improving respiratory function (forced expiratory flow in 1 s and peak expiratory flow rate) when given in the once daily regimen, whereas clinical measures (number of weekly asthma attacks) were most improved by twice daily dosing. There was no significant difference between the effectiveness of azelastine and that of ketotifen. Treatments were equally well tolerated and a low incidence of side-effects was reported. In conclusion, 8 mg/day azelastine, in either a single or twice daily dosage regimen may be regarded as providing effective prophylaxis against bronchial asthma. |
| تدمد: | 1473-2300 0300-0605 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73385fe17f7b9620625b18eea5ab7e80Test https://doi.org/10.1177/030006058901700304Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....73385fe17f7b9620625b18eea5ab7e80 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14732300 03000605 |
|---|