The Relationship between Over-expression of Glial Cell-derived Neurotrophic Factor and Its RET Receptor with Progression and Prognosis of Human Pancreatic Cancer
| العنوان: | The Relationship between Over-expression of Glial Cell-derived Neurotrophic Factor and Its RET Receptor with Progression and Prognosis of Human Pancreatic Cancer |
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| المؤلفون: | Mengtao Zhou, Xiuling Wu, Qiqiang Zeng, Y Cheng, Qiankun Zhang, Shaoliang Han, Zhengping Yu, Ka-te Huang, Qian D. Zhu |
| المصدر: | Journal of International Medical Research. 36:656-664 |
| بيانات النشر: | SAGE Publications, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Adult, Male, Pathology, medicine.medical_specialty, Perineural invasion, Benign Pancreatic Neoplasm, Kaplan-Meier Estimate, Biochemistry, Metastasis, Neurotrophic factors, Pancreatic cancer, Glial cell line-derived neurotrophic factor, medicine, Humans, Neoplasm Invasiveness, Glial Cell Line-Derived Neurotrophic Factor, Survival rate, Aged, Pain Measurement, biology, business.industry, Proto-Oncogene Proteins c-ret, Biochemistry (medical), Cell Biology, General Medicine, Middle Aged, Prognosis, medicine.disease, Pancreatic Neoplasms, nervous system, Disease Progression, biology.protein, Female, CA19-9, business |
| الوصف: | We used immunohistochemical staining to assess protein over-expression of glial cell-derived neurotrophic factor (GDNF) and its RET receptor tyrosine kinase in patients with pancreatic cancer and benign pancreatic neoplasm, and assessed correlations with clinicopathological features and prognosis. Surgically resected pancreatic cancer patients (40/58, 68.9%) showed positive GDNF immunostaining, a significantly higher frequency than in patients with benign pancreatic tumour (3/11, 27.3%). Intrapancreatic neural invasion by cancer cells was significantly related to over-expression of GDNF. Strongly positive expression of GDNF was significantly more frequent than lesser grades of expression in patients with severe back pain before and 12 months after surgery. Expression of RET was significantly related to lymphatic invasion, survival rate after tumour resection and degree of tumour cell differentiation. We conclude that GDNF may be important in pancreatic cancer proliferation and metastasis, especially in patients with perineural invasion. Strongly positive expression of GDNF may be an indication for early intensified radiotherapy. RET expression in pancreatic cancer tissues may be a useful prognostic marker. |
| تدمد: | 1473-2300 0300-0605 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::251386e707fe5930daa4bd70f2d24de9Test https://doi.org/10.1177/147323000803600406Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....251386e707fe5930daa4bd70f2d24de9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14732300 03000605 |
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