The association between bacterial infections and the risk of coronary heart disease in type 1 diabetes
| العنوان: | The association between bacterial infections and the risk of coronary heart disease in type 1 diabetes |
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| المؤلفون: | Johan R Simonsen, Asko Järvinen, Markku Lehto, Valma Harjutsalo, Per-Henrik Groop, Carol Forsblom |
| المساهمون: | HUS Abdominal Center, Nefrologian yksikkö, University of Helsinki, Helsinki University Hospital Area, CAMM - Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, HUS Inflammation Center, Department of Medicine, Clinicum, Infektiosairauksien yksikkö, Research Programs Unit, Per Henrik Groop / Principal Investigator |
| المصدر: | Journal of Internal Medicine. 288:711-724 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Lipopolysaccharides, Male, 0301 basic medicine, Diabetic Cardiomyopathies, medicine.medical_treatment, AZITHROMYCIN, Coronary Artery Disease, SECONDARY PREVENTION, 030204 cardiovascular system & hematology, Azithromycin, Coronary artery disease, Coronary artery bypass surgery, 0302 clinical medicine, Risk Factors, ARTERY-DISEASE, Diabetic Nephropathies, Prospective Studies, Myocardial infarction, GUT MICROBIOTA, Bacterial Infections, Middle Aged, Anti-Bacterial Agents, 3. Good health, CARDIOVASCULAR-DISEASE, diabetes mellitus, Female, medicine.drug, Adult, medicine.medical_specialty, 03 medical and health sciences, INFLAMMATION, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, ENDOTOXEMIA, Humans, Risk factor, Type 1 diabetes, business.industry, diabetic nephropathy, bacterial infection, Percutaneous coronary intervention, KIDNEY-DISEASE, medicine.disease, Diabetes Mellitus, Type 1, 030104 developmental biology, ATHEROSCLEROSIS, INTERLEUKIN-6 RECEPTOR, 3121 General medicine, internal medicine and other clinical medicine, business, Follow-Up Studies |
| الوصف: | Background Diabetes increases the risk of infections as well as coronary heart disease (CHD). Whether infections increase the risk of CHD and how this applies to individuals with diabetes is unclear. Objectives To investigate the association between bacterial infections and the risk of CHD in type 1 diabetes. Methods Individuals with type 1 diabetes (n = 3781) were recruited from the Finnish Diabetic Nephropathy Study (FinnDiane), a prospective follow-up study. CHD was defined as incident events: fatal or non-fatal myocardial infarction, coronary artery bypass surgery or percutaneous coronary intervention, identified through national hospital discharge register data. Infections were identified through national register data on all antibiotic purchases from outpatient care. Register data were available from 1.1.1995-31.12.2015. Bacterial lipopolysaccharide (LPS) activity was measured from serum samples at baseline. Data on traditional risk factors for CHD were collected during baseline and consecutive visits. Results Individuals with an incident CHD event (n = 370) had a higher mean number of antibiotic purchases per follow-up year compared to those without incident CHD (1.34 [95% CI: 1.16-1.52], versus 0.79 [0.76-0.82],P |
| تدمد: | 1365-2796 0954-6820 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e619c8a6cc68d54c3d18d9145dd7db1Test https://doi.org/10.1111/joim.13138Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1e619c8a6cc68d54c3d18d9145dd7db1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652796 09546820 |
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