دورية أكاديمية
Helminth Antigen Exposure Enhances Early Immune Control of Mycobacterium tuberculosis in Monocytes and Macrophages
| العنوان: | Helminth Antigen Exposure Enhances Early Immune Control of Mycobacterium tuberculosis in Monocytes and Macrophages |
|---|---|
| المؤلفون: | Shambhuprasad Kotresh Togarsimalemath, Giggil Pushpamithran, Thomas Schön, Olle Stendahl, Robert Blomgran |
| المصدر: | Journal of Innate Immunity, Pp 1-16 (2020) |
| بيانات النشر: | Karger Publishers, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine LCC:Internal medicine |
| مصطلحات موضوعية: | mycobacterium tuberculosis, schistosoma mansoni soluble egg antigen, ascaris lumbricoides, monocytes, macrophages, innate immune control, Medicine, Internal medicine, RC31-1245 |
| الوصف: | Helminth and Mycobacterium tuberculosis (Mtb) coinfection is common and suggested to influence the risk of developing active tuberculosis (TB). It is known that helminths in contrast to TB induce a strong Th2 response in the host. However, the direct impact of helminth antigen exposure on host immunity against TB is largely unknown. Our aim was to explore the effects of helminth antigen exposure on the early immune control of Mtb in monocytes and macrophages. Ascaris lumbricoides (ASC) and Schistosoma mansoni (SM) protein antigens were used to study the immediate effect of helminth antigen exposure in monocytes, on monocyte-to-macrophage differentiation, or mature macrophages, in the control of virulent Mtb H37Rv. Pre-exposure of peripheral blood mononuclear cells reduced Mtb growth in monocytes, especially with SM, but no Th1/Th2 cytokines or activation markers indicated involvement of T cells. Monocytes exposed before maturing into macrophages reduced Mtb growth in macrophages (ASC), and pre-exposure of mature macrophages reduced (ASC) or kept Mtb growth at control levels (SM). This in vitro model shows how helminth infection directly affects the monocyte-macrophage axis at an early stage before cell-mediated immunity develops. During acute helminth coinfection or when helminth antigen concentration is elevated at the site of Mtb infection, these helminths provide an enhanced control and killing of Mtb owing to the direct stimulatory effect of helminth antigens on phagocytic cells. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1662-811X 1662-8128 |
| العلاقة: | https://www.karger.com/Article/FullText/512279Test; https://doaj.org/toc/1662-811XTest; https://doaj.org/toc/1662-8128Test |
| DOI: | 10.1159/000512279 |
| الوصول الحر: | https://doaj.org/article/1c5c9fdc3add496595f480ee86810bb8Test |
| رقم الانضمام: | edsdoj.1c5c9fdc3add496595f480ee86810bb8 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 1662811X 16628128 |
|---|---|
| DOI: | 10.1159/000512279 |