Comprehensive Mechanism, Novel Markers and Multidisciplinary Treatment of Severe Acute Pancreatitis-Associated Cardiac Injury – A Narrative Review
العنوان: | Comprehensive Mechanism, Novel Markers and Multidisciplinary Treatment of Severe Acute Pancreatitis-Associated Cardiac Injury – A Narrative Review |
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المؤلفون: | Luo,YaLan, Li,ZhaoXia, Ge,Peng, Guo,HaoYa, Li,Lei, Zhang,GuiXin, Xu,CaiMing, Chen,HaiLong |
المصدر: | Journal of Inflammation Research. |
بيانات النشر: | Dove Press, 2021. |
سنة النشر: | 2021 |
مصطلحات موضوعية: | Journal of Inflammation Research |
الوصف: | YaLan Luo,1â 3,* ZhaoXia Li,2,* Peng Ge,1â 3,* HaoYa Guo,1â 3 Lei Li,4 GuiXin Zhang,2 CaiMing Xu,2 HaiLong Chen2 1Institute (College) of Integrative Medicine, Dalian Medical University, Dalian, Liaoning, Peopleâs Republic of China; 2Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, Peopleâs Republic of China; 3Laboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, Peopleâs Republic of China; 4Department of Vascular Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, Peopleâs Republic of China*These authors contributed equally to this workCorrespondence: CaiMing Xu; HaiLong ChenDepartment of General Surgery, The First Affiliated Hospital of Dalian Medical University, Zhongshan Road 222, Dalian, 116011, Liaoning, Peopleâs Republic of ChinaTel +86-411-83635963Fax +86-411-83622844Email xucaiming_science@hotmail.com; chenhailong@dmu.edu.cnAbstract: Acute pancreatitis (AP) is one of the common acute abdominal inflammatory diseases in clinic with acute onset and rapid progress. About 20% of the patients will eventually develop into severe acute pancreatitis (SAP) characterized by a large number of inflammatory cells infiltration, gland flocculus flaky necrosis and hemorrhage, finally inducing systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS). Pancreatic enzyme activation, intestinal endotoxemia (IETM), cytokine activation, microcirculation disturbance, autonomic nerve dysfunction and autophagy dysregulation all play an essential role in the occurrence and progression of SAP. Organ dysfunction is the main cause of early death in SAP. Acute kidney injury (AKI) and acute lung injury (ALI) are common, while cardiac injury (CI) is not, but the case fatality risk is high. Many basic studies have observed obvious ultrastructure change of heart in SAP, including myocardial edema, cardiac hypertrophy, myocardial interstitial collagen deposition. Moreover, in clinical practice, patients with SAP often presented various abnormal electrocardiogram (ECG) and cardiac function. Cases complicated with acute myocardial infarction and pericardial tamponade have also been reported and even result in stress cardiomyopathy. Due to the molecular mechanisms underlying SAP-associated cardiac injury (SACI) remain poorly understood, and there is no complete, unified treatment and sovereign remedy at present, this article reviews reports referring to the pathogenesis, potential markers and treatment methods of SACI in recent years, in order to improve the understanding of cardiac injury in severe pancreatitis.Keywords: severe acute pancreatitis, cardiac injury, cardiac dysfunction, inflammatory mediators, biomarkers, treatment |
وصف الملف: | text/html |
اللغة: | English |
تدمد: | 1178-7031 8363-5963 |
الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=dovemedicalp::1430026b02d60b15b3980bc9ea35ecf5Test https://www.dovepress.com/comprehensive-mechanism-novel-markers-and-multidisciplinary-treatment--peer-reviewed-fulltext-article-JIRTest |
حقوق: | OPEN |
رقم الانضمام: | edsair.dovemedicalp..1430026b02d60b15b3980bc9ea35ecf5 |
قاعدة البيانات: | OpenAIRE |
تدمد: | 11787031 83635963 |
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