Hepatitis B Virus (HBV) Load Response to 2 Antiviral Regimens, Tenofovir/Lamivudine and Lamivudine, in HIV/ HBV-Coinfected Pregnant Women in Guangxi, China: The Tenofovir in Pregnancy (TiP) Study
| العنوان: | Hepatitis B Virus (HBV) Load Response to 2 Antiviral Regimens, Tenofovir/Lamivudine and Lamivudine, in HIV/ HBV-Coinfected Pregnant Women in Guangxi, China: The Tenofovir in Pregnancy (TiP) Study |
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| المؤلفون: | Lili Chen, Athena P. Kourtis, Liming Wang, Jeffrey Wiener, Fujie Zhang, Marc Bulterys, Colin W. Shepard, Shujia Liang, Wei Liu, Ailing Wang, Linhong Wang, Xiaoyu Wei |
| المصدر: | Journal of Infectious Diseases. 214:1695-1699 |
| بيانات النشر: | Oxford University Press (OUP), 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, China, Hepatitis B virus, Tenofovir, HIV Infections, medicine.disease_cause, Antiviral Agents, law.invention, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Pregnancy, law, medicine, Humans, Immunology and Allergy, 030212 general & internal medicine, Pregnancy Complications, Infectious, Coinfection, business.industry, Transmission (medicine), virus diseases, Lamivudine, Viral Load, Hepatitis B, medicine.disease, Virology, digestive system diseases, Clinical trial, Regimen, Treatment Outcome, Infectious Diseases, Female, 030211 gastroenterology & hepatology, business, medicine.drug |
| الوصف: | BACKGROUND There is limited information on antiviral therapy for hepatitis B virus (HBV) infection among pregnant women coinfected with human immunodeficiency virus (HIV) and HBV. METHODS A phase 2 randomized, controlled trial of a regimen containing tenofovir (TDF)/lamivudine (3TC) and a regimen containing 3TC in HIV/HBV-coinfected pregnant women in China. The HBV virological response was compared in study arms. RESULTS The median decline in the HBV DNA level was 2.60 log10 copies/mL in the TDF/3TC arm and 2.24 log10 copies/mL in the 3TC arm (P = .41). All women achieved HBV DNA levels of |
| تدمد: | 1537-6613 0022-1899 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3ea8904e657e30975750ac7c602f850Test https://doi.org/10.1093/infdis/jiw439Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b3ea8904e657e30975750ac7c602f850 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15376613 00221899 |
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