التفاصيل البيبلوغرافية
| العنوان: |
Monovalent SARS-CoV-2 mRNA Vaccine Does not Boost Omicron-Specific Immune Response in Diabetic and Control Pediatric Patients. |
| المؤلفون: |
Sariol, Alan, Vickers, Molly A, Christensen, Shannon M, Weiskopf, Daniela, Sette, Alessandro, Norris, Andrew W, Tansey, Michael J, Pinnaro, Catherina T, Perlman, Stanley |
| المصدر: |
Journal of Infectious Diseases; 4/15/2024, Vol. 229 Issue 4, p1059-1067, 9p |
| مصطلحات موضوعية: |
COVID-19 vaccines, GLYCEMIC control, SARS-CoV-2 Omicron variant, IMMUNE response, CHILD patients |
| مستخلص: |
While the immunogenicity of SARS-CoV-2 vaccines has been well described in adults, pediatric populations have been less studied. In particular, children with type 1 diabetes are generally at elevated risk for more severe disease after infections, but are understudied in terms of COVID-19 and SARS-CoV-2 vaccine responses. We investigated the immunogenicity of COVID-19 mRNA vaccinations in 35 children with type 1 diabetes (T1D) and 23 controls and found that these children develop levels of SARS-CoV-2 neutralizing antibody titers and spike protein-specific T cells comparable to nondiabetic children. However, in comparing the neutralizing antibody responses in children who received 2 doses of mRNA vaccines (24 T1D; 14 controls) with those who received a third, booster dose (11 T1D; 9 controls), we found that the booster dose increased neutralizing antibody titers against ancestral SARS-CoV-2 strains but, unexpectedly, not Omicron lineage variants. In contrast, boosting enhanced Omicron variant neutralizing antibody titers in adults. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
