التفاصيل البيبلوغرافية
| العنوان: |
Elevation of Liver Fibrosis Index FIB-4 Is Associated With Poor Clinical Outcomes in Patients With COVID-19. |
| المؤلفون: |
Ibáñez-Samaniego, Luis, Bighelli, Federico, Usón, Clara, Caravaca, Celia, Carrillo, Carlos Fernández, Romero, Miriam, Barreales, Mónica, Perelló, Christie, Madejón, Antonio, Marcos, Aránzazu Caballero, Albillos, Agustín, Fernández, Inmaculada, García-Samaniego, Javier, Calleja, José Luis, Bañares, Rafael |
| المصدر: |
Journal of Infectious Diseases; 9/1/2020, Vol. 222 Issue 5, p726-733, 8p |
| مصطلحات موضوعية: |
COVID-19, CARDIOVASCULAR diseases risk factors, FIBROSIS, RESPIRATORY diseases, LIVER |
| مستخلص: |
Background: COVID-19 is a potentially severe disease caused by the recently described SARS-CoV-2. Whether liver fibrosis might be a relevant player in the natural history of COVID-19 is currently unknown. We aimed to evaluate the association between FIB-4 and the risk of progression to critical illness in middle-aged patients with COVID-19.Methods: In this multicenter, retrospective study with prospective follow-up of 160 patients aged 35-65 years with COVID-19, FIB-4, clinical, and biochemical variables were collected at baseline. FIB-4 ≥2.67 defined patients with risk for advanced liver fibrosis.Results: Risk for advanced fibrosis was estimated in 28.1% of patients. Patients with FIB-4 ≥2.67 more frequently required mechanical ventilation (37.8% vs 18.3%; P = .009). In multivariate analysis, FIB-4 ≥2.67 (odds ratio [OR], 3.41; 95% confidence interval [CI], 1.30-8.92), cardiovascular risk factors (OR, 5.05; 95% CI, 1.90-13.39), previous respiratory diseases (OR, 4.54; 95% CI, 1.36-15.10), and C-reactive protein (OR, 1.01; 95% CI, 1.01-1.02) increased significantly the risk of ICU admission. Bootstrap confirmed FIB-4 as an independent risk factor.Conclusions: In middle-aged patients with COVID-19, FIB-4 may have a prognostic role. The link between liver fibrosis and the natural history of COVID-19 should be evaluated in future studies. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
