Circulating plasmacytoid dendritic cells in acutely infected patients with hepatitis C virus genotype 4 are normal in number and phenotype
| العنوان: | Circulating plasmacytoid dendritic cells in acutely infected patients with hepatitis C virus genotype 4 are normal in number and phenotype |
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| المؤلفون: | Matthew L. Albert, Sherif El Kafrawy, Melissa E. Laird, Jérémie Decalf, Mona Rafik, Mostafa K. Mohamed, Brad R. Rosenberg, Armanda Casrouge, Arnaud Fontanet, Maha Hamdy, Rasha Saleh, Mohammed Abdel-Hamid, Hala Mansour, Noha Sharaf Eldin |
| المساهمون: | liver diseases research unit [Le Caire], National Hepatology and Tropical Medicine Research Institute, Immunobiologie des Cellules Dendritiques, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Faculty of medicine [Le Caire], Université Ain Shams, Weill Cornell/Rockefeller/Sloan-Kettering Tri-Institutional MD/PhD Program, Rockefeller University [New York]-Weill Medical College of Cornell University [New York], Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology, Pasteur-Cnam Risques infectieux et émergents (PACRI), Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Faculty of Medicine [Minia], Minia University, ' Agence Nationale de Recherches sur le SIDA et les hépatites virales' (ANRS 12135 and ANRS 12122), the European Research Council (MLA), and the Pasteur Foundation (MEL)., Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM) |
| المصدر: | The Journal of Infectious Diseases Journal of Infectious Diseases Journal of Infectious Diseases, 2010, 202 (11), pp.1671-1675. ⟨10.1086/656777⟩ Journal of Infectious Diseases, Oxford University Press (OUP), 2010, 202 (11), pp.1671-1675. ⟨10.1086/656777⟩ |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Genotype, Hepacivirus, Hepatitis C virus, medicine.medical_treatment, medicine.disease_cause, Virus, 03 medical and health sciences, Major Articles and Brief Reports, 0302 clinical medicine, Immune system, medicine, Immunology and Allergy, Humans, 030304 developmental biology, 0303 health sciences, Innate immune system, biology, Reverse Transcriptase Polymerase Chain Reaction, Toll-Like Receptors, virus diseases, hemic and immune systems, Dendritic cell, Hepatitis C, Immunotherapy, Dendritic Cells, biology.organism_classification, medicine.disease, Virology, digestive system diseases, 3. Good health, Infectious Diseases, Phenotype, 030220 oncology & carcinogenesis, Immunology, RNA, Viral, [SDV.IMM]Life Sciences [q-bio]/Immunology, Egypt |
| الوصف: | International audience; The incidence of hepatitis C virus (HCV) genotype 4 infection in Egypt provides a unique opportunity to study the innate immune response to symptomatic acute HCV infection. We investigated whether plasmacytoid dendritic cells (pDCs) are activated as a result of HCV infection. We demonstrate that, even during symptomatic acute infection, circulating pDCs maintained a similar precursor frequency and resting phenotype, compared with pDCs in healthy individuals. Moreover, stimulation with a Toll-like receptor 9 agonist resulted in an intact inflammatory response. These data support the growing consensus that pDCs are not directly activated by HCV and therefore are viable targets for immunotherapy throughout HCV infection. |
| اللغة: | English |
| تدمد: | 0022-1899 1537-6613 |
| DOI: | 10.1086/656777 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17560d21ace189a2b1ac60b9b9b5809dTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....17560d21ace189a2b1ac60b9b9b5809d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00221899 15376613 |
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| DOI: | 10.1086/656777 |