دورية أكاديمية
Elevated serum lactate dehydrogenase aids prediction of mortality in Pneumocystis jirovecii pneumonia without underlying human immunodeficiency virus infection – Derivation of a clinical risk score
| العنوان: | Elevated serum lactate dehydrogenase aids prediction of mortality in Pneumocystis jirovecii pneumonia without underlying human immunodeficiency virus infection – Derivation of a clinical risk score |
|---|---|
| المؤلفون: | Matthew Chung Yi Koh, Jinghao Nicholas Ngiam, Paul Anantharajah Tambyah, Lionel Hon-Wai Lum |
| المصدر: | Journal of Infection and Public Health, Vol 17, Iss 7, Pp 102439- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Infectious and parasitic diseases LCC:Public aspects of medicine |
| مصطلحات موضوعية: | Pneumocystis jirovecii pneumonia, Risk score, Mortality, Non-HIV, Lactate dehydrogenase, Infectious and parasitic diseases, RC109-216, Public aspects of medicine, RA1-1270 |
| الوصف: | Pneumocystis jirovecii pneumonia (PCP) is associated with significant mortality amongst patients without underlying human immunodeficiency virus infection (HIV). We sought to develop a risk score to predict mortality in this population. We reviewed patients with a presumed or confirmed PCP and a negative HIV test from 2006–2023. We constructed a multivariable model to identify parameters independently associated with mortality and the adjusted odds ratios were converted to weights to derive a risk score. Subsequently, we compared the performance of our score to the CURB-65 score by means of area under receiver operating characteristic curve (AUC). In total, we examined 93 patients with PCP without HIV. Mortality was 31.2%. Risk factors for mortality included older age, male sex and high serum lactate dehydrogenase levels (LDH) and C-reactive protein levels. A risk score was derived comprising age> 65 years (2 points), male sex (2 points) and LDH> 770 U/L (3 points). Our risk score (AUC 0.71, 95%CI 0.60–0.82) performed better than the CURB-65 score (AUC 0.53, 95%CI 0.41–0.66). A low-risk score of 0–1 had excellent negative predictive value for mortality (97.5%). In conclusion, a risk score comprising age, sex and LDH can predict mortality in PCP without underlying HIV and help with prognostication. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1876-0341 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S1876034124001369Test; https://doaj.org/toc/1876-0341Test |
| DOI: | 10.1016/j.jiph.2024.04.023 |
| الوصول الحر: | https://doaj.org/article/5233a4c5c7c74532aafd78838680da68Test |
| رقم الانضمام: | edsdoj.5233a4c5c7c74532aafd78838680da68 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 18760341 |
|---|---|
| DOI: | 10.1016/j.jiph.2024.04.023 |