التفاصيل البيبلوغرافية
| العنوان: |
IL-21 Receptor Is Critical for the Development of Memory B Cell Responses. |
| المؤلفون: |
Rankin, Andrew L1, MacLeod, Heather1, Keegan, Sean1, Andreyeva, Tatyana1, Lowe, Leslie1, Bloom, Laird2, Collins, Mary1, Nickerson-Nutter, Cheryl1, Young, Deborah1 deborah.young@pflzer.com, Guay, Heath1 |
| المصدر: |
Journal of Immunology. 1/15/2011, Vol. 186 Issue 2, p667-674. 8p. |
| مصطلحات موضوعية: |
*IMMUNITY, *B cells, *IMMUNIZATION, *GLOBULINS, *VACCINATION, *BONE marrow |
| مستخلص: |
Development of long-term humoral immunity, characterized by the formation of long-lived plasma cells (PCs) in the bone marrow and memory B cells, is a critical component of protective immunity to pathogens, and as such it is the major goal of vaccination. However, the mechanisms involved in the generation of long-term humoral immunity remain poorly understood. In this study, we used IL-21R-deficient (IL-21R.KO) mice to examine the role of the IL-21 pathway in the development of the B cell memory response. Primary IgG serum Ab responses to the T cell-dependent Ag 4-hydroxy-3-nitrophenylacetyl (NP) hapten conjugated to chicken γ globulin were delayed in IL-21R.KO mice, but reached normal titers within 3 to 4 wk of immunization. IL-21R.KO mice formed germinal centers and generated normal numbers of PCs in their bone marrow. Additionally, memory B cell formation was similar in wild-type and IL-21R.KO mice. However, NP-specific memory B cells and PCs failed to expand following secondary immunization of LL-21R.KO mice, and consequently, secondary IgG Ab responses to NP hapten conjugated to chicken γ globulin were significantly impaired. These results identify the IL-21 pathway as a critical component of the memory B cell response. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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