التفاصيل البيبلوغرافية
| العنوان: |
Igs Expressed by Chronic Lymphocytic Leukemia B Cells Show Limited Binding-Site Structure Variability. |
| المؤلفون: |
Marcatili, Paolo1 paolo.marcatili@gmail.com, Ghiotto, Fabio2, Tenca, Claudya2, Chailyan, Anna1, Mazzarello, Andrea N.2, Xiao-Jie Yan3, Colombo, Monica4, Albesiano, Emilia3, Bagnara, Davide3, Cutrona, Giovanna4, Morabito, Fortunato5, Bruno, Silvia2, Ferrarini, Manlio4, Chiorazzi, Nicholas3,6,7,8, Tramontano, Anna1,9, Fais, Franco2 franco.fais@unige.it |
| المصدر: |
Journal of Immunology. 6/1/2013, Vol. 190 Issue 11, p5771-5778. 8p. |
| مصطلحات موضوعية: |
*CHRONIC lymphocytic leukemia, *B cells, *IMMUNOGLOBULINS, *GENE rearrangement, *GENETIC mutation, *ANTIGENS |
| مستخلص: |
Ag selection has been suggested to play a role in chronic lymphocytic leukemia (CLL) pathogenesis, but no large-scale analysis has been performed so far on the structure of the Ag-binding sites (ABSs) of leukemic cell Igs. We sequenced both H and L chain V(D)J rearrangements from 366 CLL patients and modeled their three-dimensional structures. The resulting ABS structures were clustered into a small number of discrete sets, each containing ABSs with similar shapes and physicochemical properties. This structural classification correlates well with other known prognostic factors such as Ig mutation status and recurrent (stereotyped) receptors, but it shows a better prognostic value, at least in the case of one structural cluster for which clinical data were available. These findings suggest, for the first time, to our knowledge, on the basis of a structural analysis of the Ab-binding sites, that selection by a finite quota of antigenic structures operates on most CLL cases, whether mutated or unmutated. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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