التفاصيل البيبلوغرافية
| العنوان: |
Cutting Edge: Cell-Autonomous Control of IL-7 Response Revealed in a Novel Stage of Precursor B Cells. |
| المؤلفون: |
Sandoval, Gabriel J.1, Graham, Daniel B.1, Bhattacharya, Deepta1, Sleckman, Barry P.1,2, Xavier, Ramnik J.3,4, Swat, Wojciech1,2 swat@wustl.edu |
| المصدر: |
Journal of Immunology. 3/15/2013, Vol. 190 Issue 6, p2485-2489. 5p. |
| مصطلحات موضوعية: |
*B cell differentiation, *INTERLEUKIN-7, *INTERLEUKIN-7 receptors, *B cell receptors, *MYC oncogenes, *GENE rearrangement |
| مستخلص: |
During early stages of B-lineage differentiation in bone marrow, signals emanating from IL-7R and pre-BCR are thought to synergistically induce proliferative expansion of progenitor cells. Paradoxically, loss of pre-BCR-signaling components is associated with leukemia in both mice and humans. Exactly how progenitor B cells perform the task of balancing proliferative burst dependent on IL-7 with the termination of IL-7 signals and the initiation of L chain gene rearrangement remains to be elucidated. In this article, we provide genetic and functional evidence that the cessation of the IL-7 response of pre-B cells is controlled via a cell-autonomous mechanism that operates at a discrete developmental transition inside Fraction C' (large pre-BII) marked by transient expression of c-Myc. Our data indicate that pre-BCR cooperates with IL-7R in expanding the pre-B cell pool, but it is also critical to control the differentiation program shutting off the c-Myc gene in large pre-B cells. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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