التفاصيل البيبلوغرافية
| العنوان: |
The DNA Deamination Model of Somatic Antibody Diversification. |
| المؤلفون: |
Rajewsky, Klaus1 klaus.rajewsky@mdc-berlin.de |
| المصدر: |
Journal of Immunology. 5/1/2015, Vol. 194 Issue 9, p2041-2042. 2p. |
| مصطلحات موضوعية: |
*DEAMINATION, *IMMUNOGLOBULIN class switching, *GENE rearrangement, *MOLECULAR genetics, *ANTIBODY diversity |
| مستخلص: |
The article discusses the work being established that Ab diversity in mice and humans arises at two distinct developmental stages, wherein a primary Ab repertoire is set up in developing B cells through an ordered program of Ab V region gene rearrangements by V(D)J recombination, including sequential rearrangements during so-called receptor editing. The repertoire is modified in Ag-driven Ab responses through somatic hypermutation (SHM) and class switch recombination (CSR). |
| قاعدة البيانات: |
Academic Search Index |
