دورية أكاديمية
A G-protein-coupled chemokine receptor: A putative insertion site for a multi-pathogen recombinant capripoxvirus vaccine strategy
| العنوان: | A G-protein-coupled chemokine receptor: A putative insertion site for a multi-pathogen recombinant capripoxvirus vaccine strategy |
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| المؤلفون: | Cetre-Sossah, Catherine, Dickmu, Simon, Kwiatek, Olivier, Albina, Emmanuel |
| المصدر: | Journal of Immunological Methods |
| سنة النشر: | 2017 |
| المجموعة: | CIRAD: Agritrop (Centre de coopération internationale en recherche agronomique pour le développement) |
| مصطلحات موضوعية: | L73 - Maladies des animaux, capripoxvirus, vaccin synthétique, virose, virologie, génie génétique, thymidine, kinase, peste des petits ruminants, caprin, ovin, étude de cas, expérimentation, http://aims.fao.org/aos/agrovoc/c_1284Test, http://aims.fao.org/aos/agrovoc/c_27865Test, http://aims.fao.org/aos/agrovoc/c_8260Test, http://aims.fao.org/aos/agrovoc/c_8259Test, http://aims.fao.org/aos/agrovoc/c_15974Test, http://aims.fao.org/aos/agrovoc/c_7749Test, http://aims.fao.org/aos/agrovoc/c_11977Test, http://aims.fao.org/aos/agrovoc/c_16789Test, http://aims.fao.org/aos/agrovoc/c_3324Test, http://aims.fao.org/aos/agrovoc/c_7030Test, http://aims.fao.org/aos/agrovoc/c_24392Test, http://aims.fao.org/aos/agrovoc/c_2758Test, http://aims.fao.org/aos/agrovoc/c_3081Test, http://aims.fao.org/aos/agrovoc/c_8483Test, http://aims.fao.org/aos/agrovoc/c_5182Test |
| جغرافية الموضوع: | France, Yémen, Nigéria |
| الوصف: | Capripoxviruses (CaPVs) have been shown to be ideal viral vectors for the development of recombinant multivalent vaccines to enable delivery of immunogenic genes from ruminant pathogens. So far, the viral thymidine kinase (TK) gene is the only gene used to generate recombinants. A putative non-essential gene encoding a G-protein-coupled chemokine receptor subfamily homologue (GPCR) was targeted as an additional insertion site. Peste des petits ruminants (PPR) was chosen as a disease model. A new recombinant CaPV expressing the viral attachment hemagglutinin (H) of the PPR virus (PPRV) in the GPCR insertion site (rKS1-HPPR-GPCR) was generated in the backbone North African isolate KS1 strain of lumpy skin disease virus (LSDV). Comparison with the recombinant CaPV expressing the H of PPRV in the TK gene (rKS1-HPPR-TK) shown to induce protection against both PPR and LSD in both sheep and goats was assessed. The suitability of the GPCR gene to be a putative additional insertion site in the CaPV genome is evaluated and discussed. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| العلاقة: | http://agritrop.cirad.fr/585502Test/; A G-protein-coupled chemokine receptor: A putative insertion site for a multi-pathogen recombinant capripoxvirus vaccine strategy. Cetre-Sossah Catherine, Dickmu Simon, Kwiatek Olivier, Albina Emmanuel. 2017. Journal of Immunological Methods, 448 : 112-115.https://doi.org/10.1016/j.jim.2017.05.007Test; http://agritrop.cirad.fr/585502/1/1-s2.0-S0022175917300935-main.pdfTest |
| DOI: | 10.1016/j.jim.2017.05.007 |
| الإتاحة: | https://doi.org/10.1016/j.jim.2017.05.007Test http://agritrop.cirad.fr/585502Test/ http://agritrop.cirad.fr/585502/1/1-s2.0-S0022175917300935-main.pdfTest |
| حقوق: | Cirad license ; info:eu-repo/semantics/openAccess ; https://agritrop.cirad.fr/mention_legale.htmlTest |
| رقم الانضمام: | edsbas.1DE157DE |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jim.2017.05.007 |
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