التفاصيل البيبلوغرافية
| العنوان: |
Brief formula low‐energy‐diet for relapse management during weight loss maintenance in the Diabetes Remission Clinical Trial (DiRECT). |
| المؤلفون: |
Brosnahan, Naomi, Leslie, Wilma, McCombie, Louise, Barnes, Alison, Thom, George, McConnachie, Alex, Messow, Claudia Martina, Sattar, Naveed, Taylor, Roy, Lean, Michael E. J. |
| المصدر: |
Journal of Human Nutrition & Dietetics; Jun2021, Vol. 34 Issue 3, p472-479, 8p |
| مصطلحات موضوعية: |
PREVENTION of obesity, REGULATION of body weight, CLINICAL trials, REDUCING diets, DIABETES, DISEASE relapse, TREATMENT effectiveness, COMPARATIVE studies, WEIGHT loss, DESCRIPTIVE statistics, BODY mass index, HEALTH promotion |
| مستخلص: |
Background: Weight loss maintenance (WLM) is critical for sustaining type 2 diabetes (T2D) remission, but poorly evidenced. We evaluated brief return to formula low‐energy‐diet (LED) as relapse treatments (RTs) during the WLM phase of the Diabetes Remission Clinical Trial (DiRECT). Methods: This post‐hoc evaluation included all participants commencing the WLM phase of DiRECT. The protocol offered RT when regain of >2 kg occurred. Results: In total, 123/149 (83%) DiRECT intervention participants commenced the WLM phase after 26 (17%) had withdrawn prior to the WLM phase. Most participants [99/123 (80%)] regained >2 kg during the WLM phase, among whom 60/99 (61%) were recorded as using RT and 39/99 (39%) not using any RT. At baseline, RT users had a higher mean (SD) body mass index [35.8 (4.9) kg m−2 vs. 33.8 (3.9) kg m−2, p = 0.0231] and had greater social deprivation (P = 0.0003) than non‐users, although otherwise the groups were similar. Weight loss ≥ 2k g was achieved in 30/93 (32%) of RT attempts. At 2 years, those regaining >2 kg and using RT (n = 60) had mean (SD) weight losses of 7.4 (6.1) kg, with 25 (42%) remissions and 7 (12%) programme withdrawals. Those regaining >2 kg but not using RT (n = 39) had weight losses of 8.8 (6.0) kg, with 21 (54%) remissions and 4 (10%) programme withdrawals (all not significant). Twelve participants were never recorded as having regained >2 kg or using RTs and, at 2 years, their weight losses were 12.9 (9.2) kg, with 4 (33%) remissions and 8 (67%) programme withdrawals. Conclusions: Most people with T2D experience weight regain >2 kg during the 2 years after substantial weight loss with a LED. Only one‐third of RTs corrected their 2‐kg regain, resulting in similar weight losses, remissions and programme withdrawals at 2 years compared to those not using RTs; however, both groups had weight losses below those not recorded as regaining >2 kg during WLM. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
