التفاصيل البيبلوغرافية
العنوان:
Bile acid transporters and regulatory nuclear receptors in the liver and beyond
المؤلفون:
Emina Halilbasic , Thierry Claudel , Michael Trauner
المصدر:
Journal of Hepatology
سنة النشر:
2012
مصطلحات موضوعية:
ABCG5/8, cholesterol efflux pump, ATP-binding cassette, subfamily G, member 5/8 , NTCP (SLC10A1), sodium/taurocholate cotransporting polypeptide, solute carrier family 10, member 1 , TGR5, G protein-coupled bile acid receptor , Receptors, Cytoplasmic and Nuclear , Review , Mdr2/MDR3 (ABCB4), multidrug resistance protein 2 (rodents)/3 (human) , MRP4 (ABCC4), multidrug resistance-associated protein 4, ATP-binding cassette, subfamily C, member 4 , Intestinal absorption , 0302 clinical medicine , RXRα (NR2B1), retinoid X receptor alpha , PFIC, progressive familial intrahepatic cholestasis , FXR (NR1H4), farnesoid X receptor/bile acid receptor , AE2, anion exchanger 2 , LCA, lithocholic acid , VDR (NR1I1), vitamin D receptor. Please note that for the convenience of better readability and clarity, abbreviations for transporters and nuclear receptors were capitalized throughout this article when symbols were identical for human and rodents , 0303 health sciences , OATP1B3 (SLCO1B3, OATP8, SLC21A8), solute carrier organic anion transporter family, member 1B3 , Cholestasis , Membrane Glycoproteins , BCRP (ABCG2), breast cancer resistance protein, ATP-binding cassette, subfamily G, member 2 , BRIC, benign recurrent intrahepatic cholestasis , Bile acid , Liver Diseases , Progressive familial intrahepatic cholestasis , NR, nuclear receptor , FGF15/19, fibroblast growth factor 15/19 , G protein-coupled bile acid receptor , GLP-1, glucagon like peptide 1 , MRP3 (ABCC3), multidrug resistance-associated protein 3, ATP-binding cassette, subfamily C, member 3 , Ursodeoxycholic acid , 3. Good health , RARα (NR1B1), retinoic acid receptor alpha , TNFα, tumor necrosis factor α , Biochemistry , Liver , FGF15/19 , BA, bile acid , CAR (NR1I3), constitutive androstane receptor , 030211 gastroenterology & hepatology , medicine.drug , NAFLD, non-alcoholic fatty liver disease , PXR (NR1I2), pregnane X receptor , medicine.drug_class , PH, partial hepatectomy , IL6, interleukin 6 , NASH, non-alcoholic steatohepatitis , 6-ECDCA, 6-ethylchenodeoxycholic acid , LXRα (NR1H3), liver X receptor alpha , Biology , MRP2 (ABCC2), multidrug resistance-associated protein 2, ATP-binding cassette, subfamily C, member 2 , UDCA, ursodeoxycholic acid , Bile Acids and Salts , 03 medical and health sciences , medicine , Animals , Humans , ICP, intrahepatic cholestasis of pregnancy , MDR1 (ABCB1), p-glycoprotein, ATP-binding cassette, subfamily B, member 1 , 030304 developmental biology , GR (NR3C1), glucocorticoid receptor , TPN, total parenteral nutrition , Hepatology , Liver receptor homolog-1 , BSEP (ABCB11), bile salt export pump , HNF1α, hepatocyte nuclear factor 1 alpha , medicine.disease , LRH-1 (NR5A2), liver receptor homolog-1 , Bile acids , OSTαβ, organic solute transporter alpha/beta , Liver Regeneration , EGFR, epidermal growth factor receptor , Bile acids, Cholestasis, Fatty liver disease, Gallstones, Liver regeneration, Liver cancer , norUDCA, norursodeoxycholic acid , PSC, primary sclerosing cholangitis , OATP1B1 (SLCO1B1, OATP2, OATP-C, SLC21A6), solute carrier organic anion transporter family, member 1B1 , SRC2, p160 steroid receptor coactivator , PPARα (NR1C1), peroxisome proliferator-activated receptor alpha , AMPK, AMP activated protein kinase , SHP (NR0B2), short heterodimer partner , OATP1A2 (SLCO1A2, OATP1, OATP-A, SLC21A3), solute carrier organic anion transporter family, member 1A2 , PBC, primary biliary cirrhosis , IBABP (FABP6, ILBP), intestinal bile acid-binding protein, fatty acid-binding protein 6 , Carrier Proteins , HCC, hepatocellular carcinoma , HNF4α (NR2A1), hepatocyte nuclear factor 4 alpha , PPARγ (NR1C3), peroxisome proliferator-activated receptor gamma
الوصف:
Summary Bile acid (BA) transporters are critical for maintenance of the enterohepatic BA circulation where BAs exert their multiple physiological functions including stimulation of bile flow, intestinal absorption of lipophilic nutrients, solubilization and excretion of cholesterol, as well as antimicrobial and metabolic effects. Tight regulation of BA transporters via nuclear receptors is necessary to maintain proper BA homeostasis. Hereditary and acquired defects of BA transporters are involved in the pathogenesis of several hepatobiliary disorders including cholestasis, gallstones, fatty liver disease and liver cancer, but also play a role in intestinal and metabolic disorders beyond the liver. Thus, pharmacological modification of BA transporters and their regulatory nuclear receptors opens novel treatment strategies for a wide range of disorders.
تدمد:
1600-0641
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5e9e0dc14c7aa1eedb7912aef1d18f5Test https://pubmed.ncbi.nlm.nih.gov/22885388Test
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....a5e9e0dc14c7aa1eedb7912aef1d18f5
قاعدة البيانات:
OpenAIRE
