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Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications

التفاصيل البيبلوغرافية
العنوان: Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications
المؤلفون: Xinyang Zhong, Xuefeng He, Yaxian Wang, Zijuan Hu, Huixia Huang, Senlin Zhao, Ping Wei, Dawei Li
المصدر: Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-29 (2022)
بيانات النشر: BMC, 2022.
سنة النشر: 2022
المجموعة: LCC:Diseases of the blood and blood-forming organs
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
مصطلحات موضوعية: Colorectal cancer, Warburg effect, Metastasis, Tumor microenvironment, Therapeutics, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Abstract Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related death worldwide. Countless CRC patients undergo disease progression. As a hallmark of cancer, Warburg effect promotes cancer metastasis and remodels the tumor microenvironment, including promoting angiogenesis, immune suppression, cancer-associated fibroblasts formation and drug resistance. Targeting Warburg metabolism would be a promising method for the treatment of CRC. In this review, we summarize information about the roles of Warburg effect in tumor microenvironment to elucidate the mechanisms governing Warburg effect in CRC and to identify novel targets for therapy.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1756-8722
العلاقة: https://doaj.org/toc/1756-8722Test
DOI: 10.1186/s13045-022-01358-5
الوصول الحر: https://doaj.org/article/3b221f4e4ac5417b8cc1b551a49ad33aTest
رقم الانضمام: edsdoj.3b221f4e4ac5417b8cc1b551a49ad33a
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:17568722
DOI:10.1186/s13045-022-01358-5