دورية أكاديمية
How to select IgG subclasses in developing anti-tumor therapeutic antibodies
| العنوان: | How to select IgG subclasses in developing anti-tumor therapeutic antibodies |
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| المؤلفون: | Jifeng Yu, Yongping Song, Wenzhi Tian |
| المصدر: | Journal of Hematology & Oncology, Vol 13, Iss 1, Pp 1-10 (2020) |
| بيانات النشر: | BMC, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Diseases of the blood and blood-forming organs LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Therapeutic antibody, IgG subclass, Fcγ receptor, ADCC, ADCP, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Abstract The intact antibody of human immunoglobulin (IgG) is composed of the fragment for antigen binding (Fab) and the crystallizable fragment (Fc) for binding of Fcγ receptors. Among the four subclasses of human IgG (IgG1, IgG2, IgG3, IgG4), which differ in their constant regions, particularly in their hinges and CH2 domains, IgG1 has the highest FcγR-binding affinity, followed by IgG3, IgG2, and IgG4. As a result, different subclasses have different effector functions such as antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP). Fcγ receptors include six subtypes (FcγRI, FcγRIIA, FcγRIIB, FcγRIIC, FcγRIIIA, FcγRIIIB) which differ in cellular distribution, binding affinity to Fc, and the resulting biological activity. Therefore, when developing anti-tumor therapeutic antibodies, including single-targeted antibodies, bi-specific antibodies (BsAbs), and antibody-drug conjugates (ADCs), many factors, such as target biology, cellular distribution of the targets, the environments of particular tumor types, as well as the proposed mechanism of action (MOA), must be taken into consideration. This review outlines fundamental strategies that are required to select IgG subclasses in developing anti-tumor therapeutic antibodies. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1756-8722 |
| العلاقة: | http://link.springer.com/article/10.1186/s13045-020-00876-4Test; https://doaj.org/toc/1756-8722Test |
| DOI: | 10.1186/s13045-020-00876-4 |
| الوصول الحر: | https://doaj.org/article/701307dbf636423199264ff9df38a754Test |
| رقم الانضمام: | edsdoj.701307dbf636423199264ff9df38a754 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17568722 |
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| DOI: | 10.1186/s13045-020-00876-4 |