Reduce Mortality and Morbidity in Acute Myeloid Leukemia With Hyperleukocytosis With Early Admission in Intensive Care Unit: A Retrospective Analysis
| العنوان: | Reduce Mortality and Morbidity in Acute Myeloid Leukemia With Hyperleukocytosis With Early Admission in Intensive Care Unit: A Retrospective Analysis |
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| المؤلفون: | Pierre-Yves Dumas, Harmony Leroy, Titouan Cazaubiel, Nathan Mottal, Olivier Guisset, Mathieu Sauvezie, Fabrice Camou, Francois-Xavier Gros, Nahema Issa, Arnaud Pigneux, Gaelle Mourissoux, Thibaut Leguay |
| المصدر: | Journal of Hematology |
| بيانات النشر: | Elmer Press, Inc., 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Hematology department, medicine.medical_specialty, health care facilities, manpower, and services, medicine.medical_treatment, Early admission, law.invention, 03 medical and health sciences, 0302 clinical medicine, law, Retrospective analysis, Clinical endpoint, Medicine, Intensive care unit, Mortality, Chemotherapy, Acute myeloid leukemia, business.industry, Myeloid leukemia, Retrospective cohort study, 030220 oncology & carcinogenesis, Emergency medicine, Original Article, Hyperleukocytosis, business, 030215 immunology |
| الوصف: | Background: Patients presenting with acute myeloid leukemia (AML) at diagnosis are at high risk of severe complications and death, particularly with high white blood cell (WBC) count. In this retrospective study, we evaluate interest of early and systematic support in the intensive care unit (ICU) for AML with hyperleukocytosis (AML-HL) at diagnosis. Methods: Patients with AML-HL, defined by WBC > 50 × 10 9 /L, primary referred in ICU (“Early ICUâ€) without organ failure and before initiating chemotherapy induction were compared to patients first admitted in the Hematology Department who required a secondary transfer in ICU ( “Late ICU” ) or not ( “No ICU” ). Primary end point was mortality during the first month, and secondary end points were the use of life-sustaining therapies in ICU and risk factors for ICU transfer and mortality. Results: One hundred fifty-four patients were included: 77 (50%) to the group “No ICU” , 18 (12%) to “Late ICU†and 59 (38%) to “Early ICU” . Mortality at day 30 was higher in “Late ICU†than in "Early ICU" and "No ICU", with 27.8%; 16.9% and 2.6% respectively (P < 0.001). "Late ICU" patients had an increased use of life-sustaining therapy comparing to "Early ICU" patients (56% vs. 29%, P = 0.04). Conclusions: Early referral to ICU reduces morbidity and seems an effective strategy to reduce short-term mortality in AML-HL at diagnosis. J Hematol. 2020;9(4):109-115 doi: https://doi.org/10.14740/jh691Test |
| تدمد: | 1927-1220 1927-1212 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5c590b587e8ee0dde5839435a4e1ecTest https://doi.org/10.14740/jh691Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2e5c590b587e8ee0dde5839435a4e1ec |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19271220 19271212 |
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