التفاصيل البيبلوغرافية
| العنوان: |
Cerebral endothelial dysfunction in reversible cerebral vasoconstriction syndrome: a case-control study. |
| المؤلفون: |
Choi, Hyun, Lee, Mi, Chung, Chin-Sang |
| المصدر: |
Journal of Headache & Pain; 2/23/2017, Vol. 18 Issue 1, p1-6, 6p |
| مصطلحات موضوعية: |
CEREBELLUM, CEREBRAL arteries, CEREBRAL circulation, ENDOTHELIUM, MIGRAINE, TRANSCRANIAL Doppler ultrasonography, BREATH holding, VASOCONSTRICTION, CASE-control method |
| مستخلص: |
Background: The aim of this study is to investigate cerebral endothelial dysfunction in patients with reversible cerebral vasoconstriction syndrome (RCVS). Methods: We prospectively recruited patients with RCVS, age-matched controls with episodic migraine, and age-matched healthy controls at Samsung Medical Center from Apr 2015 to Jul 2016. All participants underwent transcranial Doppler evaluation, with a breath-holding maneuver, for the evaluation of bilateral middle cerebral arteries (MCAs), posterior cerebral arteries (PCAs), and the basilar artery (BA). The breath-holding index (BHI) was used to measure cerebral endothelium-dependent vasodilation. Follow-up BHIs were recorded in selected patients with RCVS after 3 months. Results: A total of 84 subjects were recruited for this study ( n = 28 in each group of RCVS, episodic migraine, and healthy control; mean age, 49.8 years). The RCVS group showed lower BHIs in all basal arteries, in comparison to healthy controls ( p < 0.001, 0.009 for bilateral MCAs, p < 0.001 and 0.028 for bilateral PCAs, and p = 0.060 for the BA). Compared to migraineurs, RCVS patients had lower BHIs only in the anterior circulation ( p = 0.002 and 0.038 for bilateral MCAs; p = 0.069 and 0.247 for bilateral PCAs; p = 0.120 for the BA). Of the 10 patients who had follow-up BHIs at 3 months, 7 showed complete normalization, while three did not. Conclusions: Cerebral endothelial function is impaired in a widespread distribution in RCVS. Its role in the pathogenesis and clinical outcome of RCVS should be determined in further studies. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Headache & Pain is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder