التفاصيل البيبلوغرافية
| العنوان: |
Systematic approach to identify therapeutic targets and functional pathways for the cervical cancer. |
| المؤلفون: |
Hasan, Md. Tanvir, Islam, Md. Rakibul, Islam, Md. Rezwan, Altahan, Baraa Riyadh, Ahmed, Kawsar, Bui, Francis M., Azam, Sami, Moni, Mohammad Ali |
| المصدر: |
Journal of Genetic Engineering & Biotechnology; 2/1/2023, Vol. 21 Issue 1, p1-17, 17p |
| مصطلحات موضوعية: |
CERVICAL cancer, DRUG target, GENE regulatory networks, BREAST cancer, THERAPEUTICS, ENDOMETRIAL cancer |
| مستخلص: |
Background: In today's society, cancer has become a big concern. The most common cancers in women are breast cancer (BC), endometrial cancer (EC), ovarian cancer (OC), and cervical cancer (CC). CC is a type of cervix cancer that is the fourth most common cancer in women and the fourth major cause of death. Results: This research uses a network approach to discover genetic connections, functional enrichment, pathways analysis, microRNAs transcription factors (miRNA-TF) co-regulatory network, gene-disease associations, and therapeutic targets for CC. Three datasets from the NCBI's GEO collection were considered for this investigation. Then, using a comparison approach between the datasets, 315 common DEGs were discovered. The PPI network was built using a variety of combinatorial statistical approaches and bioinformatics tools, and the PPI network was then utilized to identify hub genes and critical modules. Conclusion: Furthermore, we discovered that CC has specific similar links with the progression of different tumors using Gene Ontology terminology and pathway analysis. Transcription factors-gene linkages, gene-disease correlations, and the miRNA-TF co-regulatory network were revealed to have functional enrichments. We believe the candidate drugs identified in this study could be effective for advanced CC treatment. [ABSTRACT FROM AUTHOR] |
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