Evaluation of smallpox vaccines using variola neutralization
| العنوان: | Evaluation of smallpox vaccines using variola neutralization |
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| المؤلفون: | Victoria A. Olson, Scott K. Smith, Robert B. Belshe, Sharon E. Frey, Christine M. Hughes, Robert C. Holman, Lihan Yan, Frances K. Newman, Inger K. Damon, Whitni Davidson, Kevin L. Karem |
| المصدر: | Journal of General Virology. 90:1962-1966 |
| بيانات النشر: | Microbiology Society, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | animal diseases, viruses, Biology, Antibodies, Viral, complex mixtures, Virus, Dryvax, chemistry.chemical_compound, Neutralization Tests, Virology, medicine, Animals, Humans, Smallpox, Smallpox vaccine, Animal, virus diseases, ACAM2000, Variola virus, medicine.disease, Vaccination, chemistry, Immunology, Vaccinia, Smallpox Vaccine |
| الوصف: | The search for a ‘third’-generation smallpox vaccine has resulted in the development and characterization of several vaccine candidates. A significant barrier to acceptance is the absence of challenge models showing induction of correlates of protective immunity against variola virus. In this light, virus neutralization provides one of few experimental methods to show specific ‘in vitro’ activity of vaccines against variola virus. Here, we provide characterization of the ability of a modified vaccinia virus Ankara vaccine to induce variola virus-neutralizing antibodies, and we provide comparison with the neutralization elicited by standard Dryvax vaccination. |
| تدمد: | 1465-2099 0022-1317 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::910fb31649edc5a9386a407db239b794Test https://doi.org/10.1099/vir.0.010553-0Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....910fb31649edc5a9386a407db239b794 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14652099 00221317 |
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