Hepatitis C virus RNA replication is resistant to tumour necrosis factor-α
| العنوان: | Hepatitis C virus RNA replication is resistant to tumour necrosis factor-α |
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| المؤلفون: | Ralf Bartenschlager, Kerstin Barth, Verena Schwärzle, Michael Frese, Artur Kaul, Volker Lohmann |
| المصدر: | Journal of General Virology. 84:1253-1259 |
| بيانات النشر: | Microbiology Society, 2003. |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | Necrosis, Hepatitis C virus, Defence mechanisms, Hepacivirus, Biology, Virus Replication, medicine.disease_cause, Antiviral Agents, Interferon-gamma, Virology, Hepatitis C virus RNA, Drug Resistance, Viral, Tumor Cells, Cultured, medicine, Humans, Tumor Necrosis Factor-alpha, Hcv clearance, virus diseases, Hepatitis C, medicine.disease, digestive system diseases, NS2-3 protease, RNA, Viral, Tumor necrosis factor alpha, medicine.symptom |
| الوصف: | It was demonstrated using self-replicating hepatitis C virus (HCV) RNAs that both types of interferons (IFNs) (in particular IFN-alpha and IFN-gamma) are potent inhibitors of HCV replication in Huh-7 cells. Because IFN-gamma and tumour necrosis factor (TNF)-alpha trigger a partially overlapping set of antiviral defence mechanisms, it is tempting to speculate that TNF-alpha also inhibits HCV replication. However, this study shows that TNF-alpha does not affect HCV protein and RNA synthesis, nor does it synergistically enhance the inhibitory effect of IFN-gamma. Taken together, these results demonstrate that HCV replication in Huh-7 cells is highly resistant to TNF-alpha. It is, therefore, unlikely that the increased production of TNF-alpha, which is seen in many hepatitis C patients, contributes to HCV clearance by inducing antiviral defence mechanisms in infected hepatocytes. |
| تدمد: | 1465-2099 0022-1317 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f279a78a1fe8df90b021948627372514Test https://doi.org/10.1099/vir.0.18997-0Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f279a78a1fe8df90b021948627372514 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14652099 00221317 |
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