Therapeutic Modalities in Diabetic Nephropathy: Standard and Emerging Approaches
| العنوان: | Therapeutic Modalities in Diabetic Nephropathy: Standard and Emerging Approaches |
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| المؤلفون: | W. Brian Reeves, Alaa S. Awad, Lawand Saadulla, Emaad M. Abdel-Rahman |
| المصدر: | Journal of General Internal Medicine. 27:458-468 |
| بيانات النشر: | Springer Science and Business Media LLC, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | medicine.medical_specialty, Reviews, Blood Pressure, Nephropathy, End stage renal disease, Renin-Angiotensin System, Diabetic nephropathy, Diabetes mellitus, Internal Medicine, medicine, Albuminuria, Humans, Diabetic Nephropathies, Intensive care medicine, Glycemic, Proteinuria, Primary Health Care, biology, business.industry, Angiotensin-converting enzyme, medicine.disease, Hyperglycemia, Hypertension, Disease Progression, biology.protein, medicine.symptom, business, Biomarkers |
| الوصف: | Diabetes mellitus is the leading cause of end stage renal disease and is responsible for more than 40% of all cases in the United States. Current therapy directed at delaying the progression of diabetic nephropathy includes intensive glycemic and optimal blood pressure control, proteinuria/albuminuria reduction, interruption of the renin-angiotensin-aldosterone system through the use of angiotensin converting enzyme inhibitors and angiotensin type-1 receptor blockers, along with dietary modification and cholesterol lowering agents. However, the renal protection provided by these therapeutic modalities is incomplete. More effective approaches are urgently needed. This review highlights the available standard therapeutic approaches to manage progressive diabetic nephropathy, including markers for early diagnosis of diabetic nephropathy. Furthermore, we will discuss emerging strategies such as PPAR-gamma agonists, Endothelin blockers, vitamin D activation and inflammation modulation. Finally, we will summarize the recommendations of these interventions for the primary care practitioner. |
| تدمد: | 1525-1497 0884-8734 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1e5cdf4b44c2c26d81c7c7f516a171eTest https://doi.org/10.1007/s11606-011-1912-5Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e1e5cdf4b44c2c26d81c7c7f516a171e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15251497 08848734 |
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