STAT3 Inhibition for Gastroenteropancreatic Neuroendocrine Tumors: Potential for a New Therapeutic Target?
| العنوان: | STAT3 Inhibition for Gastroenteropancreatic Neuroendocrine Tumors: Potential for a New Therapeutic Target? |
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| المؤلفون: | Lauren M. Postlewait, David A. Kooby, Kenneth Cardona, Alyssa M. Krasinskas, Kristen Zhelnin, Bassel F. El-Rayes, Shishir K. Maithel, Cecilia G. Ethun, Maria C. Russell, Mohammad Y. Zaidi, Alexandra G. Lopez-Aguiar |
| المصدر: | Journal of Gastrointestinal Surgery. 24:1138-1148 |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | CD31, medicine.medical_specialty, Tissue microarray, biology, business.industry, Lymphovascular invasion, Gastroenterology, Neuroendocrine tumors, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Internal medicine, Ki-67, biology.protein, Immunohistochemistry, Medicine, 030211 gastroenterology & hepatology, Surgery, Tumor location, business, STAT3 |
| الوصف: | Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are highly vascular neoplasms treated similarly, irrespective of tumor location. The expression of pro-angiogenic factors (STAT3, VEGF, and HIF-1α) and their association with adverse pathologic factors and disease recurrence following resection remains unclear. All patients with non-metastatic GEP-NETs who underwent curative-intent resection from 2000 to 2013 were included. Immunohistochemistry was performed for pro-angiogenic factors, Ki-67 index, and CD31 using tissue microarrays made in triplicate by a pathologist blinded to other clinicopathologic variables. Primary outcome was a 3-year recurrence-free survival (3-yrRFS); secondary outcomes were correlation of pro-angiogenic factors with Ki-67 index, adverse pathologic factors, and CD31 expression, a marker of microvascular density. Of 144 GEP-NETs resected, STAT3 expression was high in 12 (8%) and low in 132 (92%) pts. High STAT3 expression was associated with worse 3-yrRFS compared to low expression (55% vs 84%; p = 0.003). High VEGF expression had a 3-yrRFS of 76% vs 82% for low expression (p = 0.09). HIF-1α expression was not associated with RFS. Ki-67 ≥ 3% was associated with worse 3-yrRFS (≥ 3%: 51% vs median: 75% vs CD31 < median: 86%; p = 0.04). High STAT3 expressing tumors were more likely to have a Ki-67 ≥ 3% (42% vs 7%; p |
| تدمد: | 1873-4626 1091-255X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::53bce85128c4762a3709bbfa2422ed5dTest https://doi.org/10.1007/s11605-019-04261-6Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........53bce85128c4762a3709bbfa2422ed5d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18734626 1091255X |
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