Radiologic Complete Response with Sirolimus and Sorafenib in a Hepatocellular Carcinoma Patient who Relapsed After Orthotopic Liver Transplantation
| العنوان: | Radiologic Complete Response with Sirolimus and Sorafenib in a Hepatocellular Carcinoma Patient who Relapsed After Orthotopic Liver Transplantation |
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| المؤلفون: | Richard D. Kim, Federico Aucejo |
| المصدر: | Journal of Gastrointestinal Cancer. 42:50-53 |
| بيانات النشر: | Springer Science and Business Media LLC, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Diagnostic Imaging, Male, Niacinamide, Sorafenib, Oncology, medicine.medical_specialty, Carcinoma, Hepatocellular, Orthotopic liver transplantation, Pyridines, medicine.medical_treatment, Liver transplantation, Internal medicine, medicine, Humans, Protein Kinase Inhibitors, neoplasms, Complete response, Sirolimus, business.industry, Phenylurea Compounds, Benzenesulfonates, Liver Neoplasms, Gastroenterology, Middle Aged, medicine.disease, digestive system diseases, Recurrent Hepatocellular Carcinoma, Liver Transplantation, Radiation therapy, Treatment Outcome, surgical procedures, operative, Hepatocellular carcinoma, Neoplasm Recurrence, Local, Tomography, X-Ray Computed, business, Immunosuppressive Agents, medicine.drug |
| الوصف: | No standard therapies have been established for the treatment of recurrent hepatocellular carcinoma (HCC) after liver transplantation.Sirolimus is a mTOR inhibitor which has been used as an immunosuppressive medication in patients who are at high risk of tumor reoccurrence after liver transplantation. Sorafenib is a multikinase inhibitor approved for the treatment of advanced HCC. However the role of sorafenib in patients with HCC reoccurrence after liver transplantation is unclear.Combination of sirolimus and sorafenib appears to have synergistic effect when treating HCC in preclinical settings. We report a case of a post-liver transplant patient treated with sorafenib and sirolimus for hepatic HCC recurrence who exhibited complete radiologic response after 5A months of therapy. |
| تدمد: | 1941-6636 1941-6628 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aae85216ced2d3ef547892381b69025bTest https://doi.org/10.1007/s12029-010-9196-2Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....aae85216ced2d3ef547892381b69025b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19416636 19416628 |
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