Concordance regarding disease type and phenotypic characteristics among patients with familial inflammatory bowel disease
| العنوان: | Concordance regarding disease type and phenotypic characteristics among patients with familial inflammatory bowel disease |
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| المؤلفون: | Seung-Jae Myung, Jeong-Sik Byeon, Sung Wook Hwang, Byong Duk Ye, Soomin Noh, Eun Hye Oh, Suk-Kyun Yang, Jin Yong Kim, Sang Hyoung Park, Dong-Hoon Yang, Jae Cheol Park, Nam Seok Ham, Jeongseok Kim |
| المصدر: | Journal of Gastroenterology and Hepatology. 35:988-993 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, Concordance, Disease, Inflammatory bowel disease, Cohort Studies, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Asian People, Crohn Disease, Internal medicine, medicine, Humans, Genetic Predisposition to Disease, Family history, Hepatology, business.industry, Age Factors, Gastroenterology, Inflammatory Bowel Diseases, medicine.disease, Ulcerative colitis, Phenotype, digestive system diseases, Confidence interval, 030220 oncology & carcinogenesis, Cohort, Colitis, Ulcerative, Female, 030211 gastroenterology & hepatology, business |
| الوصف: | Background and aims The phenotypic concordance among familial cases of inflammatory bowel disease (IBD) has been rarely reported. Thus, the present study aimed to evaluate the concordance regarding disease type and phenotypic features in a large cohort of Korean patients with IBD. Methods A total of 6647 patients with IBD who visited the Asan Medical Center between June 1989 and September 2016 were enrolled in the study. When at least two familial cases existed in our cohort, they were included in the concordance analysis (κ index). The concordance between younger and older members for IBD type [Crohn's disease (CD) and ulcerative colitis (UC)] and phenotypic characteristics such as disease extent and location, disease behavior, the use of medication, and need for surgery were evaluated. Results A positive family history of IBD was noted in 216 patients with CD (7.0%) and in 238 patients with UC (6.7%). Of all patients, 167 consanguineous pairs in 146 families were identified. The crude concordance rate for IBD type was 82.6% with a κ index of 0.656 [95% confidence interval (CI): 0.545-0.768, good concordance]. There was mild concordance for disease location in CD (κ = 0.256; 95% CI: 0.007-0.505) and for the use of antitumor necrosis factor agents in UC (κ = 0.354; 95% CI: -0.049-0.757). The concordance for IBD type and several phenotypes in first-degree relative pairs was better than that in the entire pairs. Conclusions Disease type and phenotypic characteristics of patients with familial IBD may be anticipated. |
| تدمد: | 1440-1746 0815-9319 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d9c686d201d6f0818ebc607da0ed7ebTest https://doi.org/10.1111/jgh.14913Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....5d9c686d201d6f0818ebc607da0ed7eb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14401746 08159319 |
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