التفاصيل البيبلوغرافية
| العنوان: |
Clinicopathological characteristics of colorectal serrated polyposis syndrome (SPS): results of a multicenter study by the SPS Study Group in Japan. |
| المؤلفون: |
Shimohara, Yasutsugu, Urabe, Yuji, Oka, Shiro, Hisabe, Takashi, Yamada, Atsushi, Matsushita, Hiro-o, Kato, Bunichiro, Sakamoto, Hirotsugu, Horii, Joichiro, Watanabe, Daisuke, Eda, Hirotsugu, Nakamura, Fumika, Chino, Akiko, Yamamoto, Hironori, Takayama, Tetsuji, Matsumoto, Takayuki, Ishikawa, Hideki, Tanaka, Shinji |
| المصدر: |
Journal of Gastroenterology; Apr2022, Vol. 57 Issue 4, p300-308, 9p |
| مصطلحات موضوعية: |
COLON polyps, COLORECTAL cancer, CLINICAL pathology, SYNDROMES, STANDARD deviations |
| مصطلحات جغرافية: |
JAPAN |
| الشركة/الكيان: |
WORLD Health Organization |
| مستخلص: |
Background: Serrated polyposis syndrome (SPS), a type of colorectal polyposis characterized by multiple serrated polyps, is associated with a high risk of colorectal carcinoma (CRC). This study aimed to clarify the clinicopathological characteristics of SPS in Japan. Methods: We investigated the clinicopathological characteristics of patients with SPS from the "Multicenter Study on Clinicopathological Characteristics of SPS (UMIN 000032138)" by the Colorectal Serrated Polyposis Syndrome (SPS) Study Group. In this study, patients were diagnosed with SPS based on the 2019 World Health Organization (WHO) SPS diagnostic criteria. Results: Ninety-four patients were diagnosed with SPS in 10 institutions between January 2001 and December 2017. The mean number (± standard deviation [SD]) of resected lesions per patient was 11.3 ± 13.8. The mean age at diagnosis of SPS was 63.3 ± 11.6 years, and 58 patients (61.7%) were male. Eighty-seven (92.6%) and 16 (17.0%) patients satisfied WHO diagnostic criteria I and II, respectively. Nine patients (9.6%) satisfied both criteria I and II. Carcinoma (T1–T4) were observed in 21 patients (22.3%) and 24 lesions. Of the 21 patients with CRC, 19 (90.4%) satisfied diagnostic criterion I, 1 (4.8%) satisfied diagnostic criterion II, and 1 (4.8%) satisfied diagnostic criteria I and II. There was no notable difference in the prevalence of CRC among patients who met diagnostic criterion I, II, and both I and II. Conclusions: Patients with SPS have a high risk of CRC and should undergo regular surveillance colonoscopy. Raising awareness of this syndrome is crucial. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
