Cerebral Ischemia Enhances Polyamine Oxidation: Identification of Enzymatically Formed 3-Aminopropanal as an Endogenous Mediator of Neuronal and Glial Cell Death
| العنوان: | Cerebral Ischemia Enhances Polyamine Oxidation: Identification of Enzymatically Formed 3-Aminopropanal as an Endogenous Mediator of Neuronal and Glial Cell Death |
|---|---|
| المؤلفون: | Haichao Wang, Galina I. Botchkina, Janet M. Dubinsky, Malcolm E. Meistrell, Constantino Iadecola, Yousef Al-Abed, Peter K. Gregersen, John W. Eaton, Franak Batliwalla, Svetlana Ivanova, Kevin J. Tracey |
| المصدر: | The Journal of Experimental Medicine |
| بيانات النشر: | Rockefeller University Press, 1998. |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | Programmed cell death, Magnetic Resonance Spectroscopy, spermine, caspase, infarction, Immunology, Ischemia, Spermine, Pharmacology, Biology, Brain Ischemia, Cell Line, Brain ischemia, chemistry.chemical_compound, medicine, Animals, Immunology and Allergy, Cell damage, Neurons, Aldehydes, Oxidoreductases Acting on CH-NH Group Donors, Cell Death, Propylamines, apoptosis, Articles, medicine.disease, stroke, Pimagedine, Rats, Biochemistry, chemistry, Rats, Inbred Lew, Polyamine, Neuroglia, Oxidation-Reduction, Polyamine oxidase |
| الوصف: | To elucidate endogenous mechanisms underlying cerebral damage during ischemia, brain polyamine oxidase activity was measured in rats subjected to permanent occlusion of the middle cerebral artery. Brain polyamine oxidase activity was increased significantly within 2 h after the onset of ischemia in brain homogenates (15.8 ± 0.9 nmol/h/mg protein) as compared with homogenates prepared from the normally perfused contralateral side (7.4 ± 0.5 nmol/h/mg protein) (P |
| تدمد: | 1540-9538 0022-1007 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::707594e60923da5de47d868a4ab7bf1fTest https://doi.org/10.1084/jem.188.2.327Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....707594e60923da5de47d868a4ab7bf1f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15409538 00221007 |
|---|