The multiple facets of drug resistance: one history, different approaches
| العنوان: | The multiple facets of drug resistance: one history, different approaches |
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| المؤلفون: | Paula Rezende-Teixeira, Bianca Rocha-Sales, Marcelo De Souza, Camila Lauand, Beatriz Araujo Cortez, Adam A. Martens, Marcel Shiniti Urabayashi, Evandro Luís de Oliveira Niero, Jorge Henrique Neves, Gláucia Maria Machado-Santelli |
| المصدر: | Journal of Experimental & Clinical Cancer Research : CR Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Cell death, Cancer Research, Antineoplastic Agents, Review, Drug resistance, Multidrug resistance, medicine.disease_cause, Metastasis, 3D cell culture, Cancer stem cell, Neoplasms, Tumor Cells, Cultured, medicine, Animals, Humans, Heat-Shock Proteins, Cancer stem cells, business.industry, CÉLULAS CULTIVADAS DE TUMOR, Melanoma, medicine.disease, Drug Resistance, Multiple, Multiple drug resistance, Oncology, Drug Resistance, Neoplasm, Cancer cell, Immunology, Neoplastic Stem Cells, Cancer research, Drug Screening Assays, Antitumor, Neoplasm Recurrence, Local, Carcinogenesis, business, Chemoresistance |
| الوصف: | Some cancers like melanoma and pancreatic and ovarian cancers, for example, commonly display resistance to chemotherapy, and this is the major obstacle to a better prognosis of patients. Frequently, literature presents studies in monolayer cell cultures, 3D cell cultures or in vivo studies, but rarely the same work compares results of drug resistance in different models. Several of these works are presented in this review and show that usually cells in 3D culture are more resistant to drugs than monolayer cultured cells due to different mechanisms. Searching for new strategies to sensitize different tumors to chemotherapy, many methods have been studied to understand the mechanisms whereby cancer cells acquire drug resistance. These methods have been strongly advanced along the years and therapies using different drugs have been increasingly proposed to induce cell death in resistant cells of different cancers. Recently, cancer stem cells (CSCs) have been extensively studied because they would be the only cells capable of sustaining tumorigenesis. It is believed that the resistance of CSCs to currently used chemotherapeutics is a major contributing factor in cancer recurrence and later metastasis development. This review aims to appraise the experimental progress in the study of acquired drug resistance of cancer cells in different models as well as to understand the role of CSCs as the major contributing factor in cancer recurrence and metastasis development, describing how CSCs can be identified and isolated. |
| تدمد: | 1756-9966 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3ab4f156f2cad63de89c7391c0197aaTest https://doi.org/10.1186/1756-9966-33-37Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f3ab4f156f2cad63de89c7391c0197aa |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17569966 |
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