The possible role of methylglyoxal metabolism in cancer
| العنوان: | The possible role of methylglyoxal metabolism in cancer |
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| المؤلفون: | Jakob Morgenstern, Saad S. Alqahtani, Khalid O. Alfarouk, Claudiu T. Supuran, Saeed Alshahrani, Stephan J. Reshkin |
| المصدر: | Journal of Enzyme Inhibition and Medicinal Chemistry article-version (VoR) Version of Record Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 2010-2015 (2021) |
| بيانات النشر: | Informa UK Limited, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | RM1-950, Review, Review Article, chemistry.chemical_compound, Neoplasms, Methylglyoxal, Drug Discovery, medicine, cancer, Humans, Pharmacology, chemistry.chemical_classification, Molecular Structure, pH, Cancer, Glyoxal, General Medicine, Metabolism, Phosphate, medicine.disease, Cell biology, Methylglyoxal metabolism, enzyme, Metabolic pathway, Enzyme, chemistry, redox, Therapeutics. Pharmacology, Intracellular |
| الوصف: | Tumours reprogram their metabolism to acquire an evolutionary advantage over normal cells. However, not all such metabolic pathways support energy production. An example of these metabolic pathways is the Methylglyoxal (MG) one. This pathway helps maintain the redox state, and it might act as a phosphate sensor that monitors the intracellular phosphate levels. In this work, we discuss the biochemical step of the MG pathway and interrelate it with cancer. |
| تدمد: | 1475-6374 1475-6366 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46706ab0303fb1b7d78887683043767eTest https://doi.org/10.1080/14756366.2021.1972994Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....46706ab0303fb1b7d78887683043767e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14756374 14756366 |
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